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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7LDD

native AMPA receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0038023molecular_functionsignaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0038023molecular_functionsignaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
E0005102molecular_functionsignaling receptor binding
E0005515molecular_functionprotein binding
E0005789cellular_componentendoplasmic reticulum membrane
E0014069cellular_componentpostsynaptic density
E0016192biological_processvesicle-mediated transport
E0016247molecular_functionchannel regulator activity
E0030425cellular_componentdendrite
E0032281cellular_componentAMPA glutamate receptor complex
E0035249biological_processsynaptic transmission, glutamatergic
E0042391biological_processregulation of membrane potential
E0043197cellular_componentdendritic spine
E0043198cellular_componentdendritic shaft
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051668biological_processlocalization within membrane
E0098839cellular_componentpostsynaptic density membrane
E0098978cellular_componentglutamatergic synapse
E1902684biological_processnegative regulation of receptor localization to synapse
E1903743biological_processnegative regulation of anterograde synaptic vesicle transport
E2000310biological_processregulation of NMDA receptor activity
E2000311biological_processregulation of AMPA receptor activity
F0005102molecular_functionsignaling receptor binding
F0005515molecular_functionprotein binding
F0005789cellular_componentendoplasmic reticulum membrane
F0014069cellular_componentpostsynaptic density
F0016192biological_processvesicle-mediated transport
F0016247molecular_functionchannel regulator activity
F0030425cellular_componentdendrite
F0032281cellular_componentAMPA glutamate receptor complex
F0035249biological_processsynaptic transmission, glutamatergic
F0042391biological_processregulation of membrane potential
F0043197cellular_componentdendritic spine
F0043198cellular_componentdendritic shaft
F0045202cellular_componentsynapse
F0045211cellular_componentpostsynaptic membrane
F0051668biological_processlocalization within membrane
F0098839cellular_componentpostsynaptic density membrane
F0098978cellular_componentglutamatergic synapse
F1902684biological_processnegative regulation of receptor localization to synapse
F1903743biological_processnegative regulation of anterograde synaptic vesicle transport
F2000310biological_processregulation of NMDA receptor activity
F2000311biological_processregulation of AMPA receptor activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005246molecular_functioncalcium channel regulator activity
G0005262molecular_functioncalcium channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0014069cellular_componentpostsynaptic density
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0019226biological_processtransmission of nerve impulse
G0030346molecular_functionprotein phosphatase 2B binding
G0032281cellular_componentAMPA glutamate receptor complex
G0032590cellular_componentdendrite membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0035255molecular_functionionotropic glutamate receptor binding
G0045202cellular_componentsynapse
G0045211cellular_componentpostsynaptic membrane
G0051968biological_processpositive regulation of synaptic transmission, glutamatergic
G0070588biological_processcalcium ion transmembrane transport
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098839cellular_componentpostsynaptic density membrane
G0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
G0098978cellular_componentglutamatergic synapse
G0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
G1990454cellular_componentL-type voltage-gated calcium channel complex
G2000311biological_processregulation of AMPA receptor activity
G2000969biological_processpositive regulation of AMPA receptor activity
H0005245molecular_functionvoltage-gated calcium channel activity
H0005246molecular_functioncalcium channel regulator activity
H0005262molecular_functioncalcium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006816biological_processcalcium ion transport
H0014069cellular_componentpostsynaptic density
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0019226biological_processtransmission of nerve impulse
H0030346molecular_functionprotein phosphatase 2B binding
H0032281cellular_componentAMPA glutamate receptor complex
H0032590cellular_componentdendrite membrane
H0034220biological_processmonoatomic ion transmembrane transport
H0034702cellular_componentmonoatomic ion channel complex
H0035255molecular_functionionotropic glutamate receptor binding
H0045202cellular_componentsynapse
H0045211cellular_componentpostsynaptic membrane
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0070588biological_processcalcium ion transmembrane transport
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098839cellular_componentpostsynaptic density membrane
H0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
H0098978cellular_componentglutamatergic synapse
H0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
H1990454cellular_componentL-type voltage-gated calcium channel complex
H2000311biological_processregulation of AMPA receptor activity
H2000969biological_processpositive regulation of AMPA receptor activity
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
JTYR193-HIS199
site_idPS01340
Number of Residues15
DetailsCORNICHON Cornichon family signature. IafdELrtDFkNPID
ChainResidueDetails
EILE29-ASP43
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues160
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues60
DetailsIntramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsIntramembrane: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues696
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=M4","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P42262","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19490","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"16129400","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33981040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LDD","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7LDE","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues280
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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