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7LD4

Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0001973biological_processG protein-coupled adenosine receptor signaling pathway
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007584biological_processresponse to nutrient
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0032930biological_processpositive regulation of superoxide anion generation
A0035810biological_processpositive regulation of urine volume
A0044297cellular_componentcell body
A0045202cellular_componentsynapse
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0050805biological_processnegative regulation of synaptic transmission
A0051301biological_processcell division
A0051924biological_processregulation of calcium ion transport
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0098992cellular_componentneuronal dense core vesicle
A0140199biological_processnegative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
A1903561cellular_componentextracellular vesicle
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A2000179biological_processpositive regulation of neural precursor cell proliferation
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001609molecular_functionG protein-coupled adenosine receptor activity
R0001659biological_processtemperature homeostasis
R0001664molecular_functionG protein-coupled receptor binding
R0001666biological_processresponse to hypoxia
R0001883molecular_functionpurine nucleoside binding
R0001973biological_processG protein-coupled adenosine receptor signaling pathway
R0002087biological_processregulation of respiratory gaseous exchange by nervous system process
R0002674biological_processnegative regulation of acute inflammatory response
R0002686biological_processnegative regulation of leukocyte migration
R0002793biological_processpositive regulation of peptide secretion
R0003084biological_processpositive regulation of systemic arterial blood pressure
R0003085biological_processnegative regulation of systemic arterial blood pressure
R0003093biological_processregulation of glomerular filtration
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006612biological_processprotein targeting to membrane
R0006909biological_processphagocytosis
R0006954biological_processinflammatory response
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007267biological_processcell-cell signaling
R0007399biological_processnervous system development
R0008285biological_processnegative regulation of cell population proliferation
R0010035biological_processresponse to inorganic substance
R0014050biological_processnegative regulation of glutamate secretion
R0014074biological_processresponse to purine-containing compound
R0016020cellular_componentmembrane
R0016042biological_processlipid catabolic process
R0016323cellular_componentbasolateral plasma membrane
R0030425cellular_componentdendrite
R0030673cellular_componentaxolemma
R0031072molecular_functionheat shock protein binding
R0031683molecular_functionG-protein beta/gamma-subunit complex binding
R0032229biological_processnegative regulation of synaptic transmission, GABAergic
R0032244biological_processpositive regulation of nucleoside transport
R0032279cellular_componentasymmetric synapse
R0032795molecular_functionheterotrimeric G-protein binding
R0032900biological_processnegative regulation of neurotrophin production
R0035307biological_processpositive regulation of protein dephosphorylation
R0042311biological_processvasodilation
R0042321biological_processnegative regulation of circadian sleep/wake cycle, sleep
R0042323biological_processnegative regulation of circadian sleep/wake cycle, non-REM sleep
R0042734cellular_componentpresynaptic membrane
R0043025cellular_componentneuronal cell body
R0043066biological_processnegative regulation of apoptotic process
R0043195cellular_componentterminal bouton
R0043197cellular_componentdendritic spine
R0043268biological_processpositive regulation of potassium ion transport
R0043410biological_processpositive regulation of MAPK cascade
R0044297cellular_componentcell body
R0044305cellular_componentcalyx of Held
R0044877molecular_functionprotein-containing complex binding
R0045202cellular_componentsynapse
R0045211cellular_componentpostsynaptic membrane
R0045776biological_processnegative regulation of blood pressure
R0045777biological_processpositive regulation of blood pressure
R0046888biological_processnegative regulation of hormone secretion
R0046982molecular_functionprotein heterodimerization activity
R0048786cellular_componentpresynaptic active zone
R0050728biological_processnegative regulation of inflammatory response
R0050890biological_processcognition
R0050900biological_processleukocyte migration
R0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
R0050995biological_processnegative regulation of lipid catabolic process
R0050996biological_processpositive regulation of lipid catabolic process
R0051930biological_processregulation of sensory perception of pain
R0051967biological_processnegative regulation of synaptic transmission, glutamatergic
R0055089biological_processfatty acid homeostasis
R0055117biological_processregulation of cardiac muscle contraction
R0060079biological_processexcitatory postsynaptic potential
R0060292biological_processlong-term synaptic depression
R0070254biological_processmucus secretion
R0070256biological_processnegative regulation of mucus secretion
R0070328biological_processtriglyceride homeostasis
R0086004biological_processregulation of cardiac muscle cell contraction
R0097190biological_processapoptotic signaling pathway
R0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
R0110148biological_processobsolete biomineralization
R1900272biological_processnegative regulation of long-term synaptic potentiation
R1900453biological_processnegative regulation of long-term synaptic depression
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIlALLAIAVDRYLrV
ChainResidueDetails
RSER93-VAL109

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN-22
RASN-17
RASN159

site_idSWS_FT_FI2
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RALA11-ALA33
ALEU176
ATHR182
ASER327

site_idSWS_FT_FI3
Number of Residues98
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RVAL34-CYS46
RVAL103-ARG123
RGLU202-SER235
RGLN293-ASP326

site_idSWS_FT_FI4
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RPHE47-ILE69

site_idSWS_FT_FI5
Number of Residues46
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RASN70-CYS80
RASN147-SER176
RCYS260-SER267

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RLEU81-ALA102

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RALA124-TRP146

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RMET177-LEU201

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RLEU236-PHE259

site_idSWS_FT_FI10
Number of Residues24
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RILE268-ILE292

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
RCYS309

219869

PDB entries from 2024-05-15

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