7LBM

Structure of the human Mediator-bound transcription pre-initiation complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0003713	molecular_function	transcription coactivator activity
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006366	biological_process	transcription by RNA polymerase II
0	0016020	cellular_component	membrane
0	0016592	cellular_component	mediator complex
0	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
0	0042809	molecular_function	nuclear vitamin D receptor binding
0	0045893	biological_process	positive regulation of DNA-templated transcription
0	0046966	molecular_function	nuclear thyroid hormone receptor binding
0	0051123	biological_process	RNA polymerase II preinitiation complex assembly
0	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
0	0070847	cellular_component	core mediator complex
1	0003713	molecular_function	transcription coactivator activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005667	cellular_component	transcription regulator complex
1	0006355	biological_process	regulation of DNA-templated transcription
1	0006357	biological_process	regulation of transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0010628	biological_process	positive regulation of gene expression
1	0016592	cellular_component	mediator complex
1	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
1	0051123	biological_process	RNA polymerase II preinitiation complex assembly
1	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
1	0070847	cellular_component	core mediator complex
1	2000409	biological_process	positive regulation of T cell extravasation
2	0003712	molecular_function	transcription coregulator activity
2	0003713	molecular_function	transcription coactivator activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0016592	cellular_component	mediator complex
2	0030374	molecular_function	nuclear receptor coactivator activity
2	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
2	0042809	molecular_function	nuclear vitamin D receptor binding
2	0045893	biological_process	positive regulation of DNA-templated transcription
2	0046966	molecular_function	nuclear thyroid hormone receptor binding
2	0051123	biological_process	RNA polymerase II preinitiation complex assembly
2	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
2	0070847	cellular_component	core mediator complex
3	0000122	biological_process	negative regulation of transcription by RNA polymerase II
3	0001223	molecular_function	transcription coactivator binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005667	cellular_component	transcription regulator complex
3	0016592	cellular_component	mediator complex
3	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
3	0035563	biological_process	positive regulation of chromatin binding
3	0042974	molecular_function	nuclear retinoic acid receptor binding
3	0045944	biological_process	positive regulation of transcription by RNA polymerase II
3	0046965	molecular_function	nuclear retinoid X receptor binding
3	0048147	biological_process	negative regulation of fibroblast proliferation
3	0051123	biological_process	RNA polymerase II preinitiation complex assembly
3	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
3	0070847	cellular_component	core mediator complex
3	2001178	biological_process	positive regulation of mediator complex assembly
a	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
a	0000439	cellular_component	transcription factor TFIIH core complex
a	0002031	biological_process	G protein-coupled receptor internalization
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005669	cellular_component	transcription factor TFIID complex
a	0005675	cellular_component	transcription factor TFIIH holo complex
a	0006281	biological_process	DNA repair
a	0006289	biological_process	nucleotide-excision repair
a	0006351	biological_process	DNA-templated transcription
a	0006357	biological_process	regulation of transcription by RNA polymerase II
a	0006366	biological_process	transcription by RNA polymerase II
a	0006367	biological_process	transcription initiation at RNA polymerase II promoter
a	0008270	molecular_function	zinc ion binding
a	0009411	biological_process	response to UV
a	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
a	0016607	cellular_component	nuclear speck
a	0046872	molecular_function	metal ion binding
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0000974	cellular_component	Prp19 complex
A	0001055	molecular_function	RNA polymerase II activity
A	0001172	biological_process	RNA-templated transcription
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006353	biological_process	DNA-templated transcription termination
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0019900	molecular_function	kinase binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031981	cellular_component	nuclear lumen
A	0032991	cellular_component	protein-containing complex
A	0033120	biological_process	positive regulation of RNA splicing
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
A	0050436	molecular_function	microfibril binding
A	1990841	molecular_function	promoter-specific chromatin binding
b	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
b	0000439	cellular_component	transcription factor TFIIH core complex
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005669	cellular_component	transcription factor TFIID complex
b	0005675	cellular_component	transcription factor TFIIH holo complex
b	0006281	biological_process	DNA repair
b	0006289	biological_process	nucleotide-excision repair
b	0006355	biological_process	regulation of DNA-templated transcription
b	0006366	biological_process	transcription by RNA polymerase II
b	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
b	0046872	molecular_function	metal ion binding
b	0097550	cellular_component	transcription preinitiation complex
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0001055	molecular_function	RNA polymerase II activity
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003723	molecular_function	RNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
c	0000439	cellular_component	transcription factor TFIIH core complex
c	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005669	cellular_component	transcription factor TFIID complex
c	0005675	cellular_component	transcription factor TFIIH holo complex
c	0005730	cellular_component	nucleolus
c	0005737	cellular_component	cytoplasm
c	0006281	biological_process	DNA repair
c	0006289	biological_process	nucleotide-excision repair
c	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
c	0006362	biological_process	transcription elongation by RNA polymerase I
c	0006366	biological_process	transcription by RNA polymerase II
c	0006367	biological_process	transcription initiation at RNA polymerase II promoter
c	0071480	biological_process	cellular response to gamma radiation
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001055	molecular_function	RNA polymerase II activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
d	0000082	biological_process	G1/S transition of mitotic cell cycle
d	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
d	0000439	cellular_component	transcription factor TFIIH core complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005675	cellular_component	transcription factor TFIIH holo complex
d	0006281	biological_process	DNA repair
d	0006289	biological_process	nucleotide-excision repair
d	0006355	biological_process	regulation of DNA-templated transcription
d	0006357	biological_process	regulation of transcription by RNA polymerase II
d	0006367	biological_process	transcription initiation at RNA polymerase II promoter
d	0007512	biological_process	adult heart development
d	0008270	molecular_function	zinc ion binding
d	0021591	biological_process	ventricular system development
d	0043066	biological_process	negative regulation of apoptotic process
d	0045737	biological_process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
d	0046872	molecular_function	metal ion binding
d	0048661	biological_process	positive regulation of smooth muscle cell proliferation
d	0051592	biological_process	response to calcium ion
d	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
d	0070516	cellular_component	CAK-ERCC2 complex
d	0070985	cellular_component	transcription factor TFIIK complex
d	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000166	molecular_function	nucleotide binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005829	cellular_component	cytosol
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016607	cellular_component	nuclear speck
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0044237	biological_process	cellular metabolic process
e	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
e	0000439	cellular_component	transcription factor TFIIH core complex
e	0001650	cellular_component	fibrillar center
e	0001673	cellular_component	male germ cell nucleus
e	0004672	molecular_function	protein kinase activity
e	0004674	molecular_function	protein serine/threonine kinase activity
e	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005675	cellular_component	transcription factor TFIIH holo complex
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005886	cellular_component	plasma membrane
e	0006281	biological_process	DNA repair
e	0006366	biological_process	transcription by RNA polymerase II
e	0006367	biological_process	transcription initiation at RNA polymerase II promoter
e	0006468	biological_process	protein phosphorylation
e	0008094	molecular_function	ATP-dependent activity, acting on DNA
e	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
e	0016301	molecular_function	kinase activity
e	0042795	biological_process	snRNA transcription by RNA polymerase II
e	0045944	biological_process	positive regulation of transcription by RNA polymerase II
e	0048471	cellular_component	perinuclear region of cytoplasm
e	0050821	biological_process	protein stabilization
e	0051301	biological_process	cell division
e	0051726	biological_process	regulation of cell cycle
e	0070516	cellular_component	CAK-ERCC2 complex
e	0070985	cellular_component	transcription factor TFIIK complex
e	0106310	molecular_function	protein serine kinase activity
e	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005730	cellular_component	nucleolus
E	0005736	cellular_component	RNA polymerase I complex
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
E	0050821	biological_process	protein stabilization
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
f	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
f	0000439	cellular_component	transcription factor TFIIH core complex
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005675	cellular_component	transcription factor TFIIH holo complex
f	0006351	biological_process	DNA-templated transcription
f	0006357	biological_process	regulation of transcription by RNA polymerase II
f	0006367	biological_process	transcription initiation at RNA polymerase II promoter
f	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
f	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
f	0050821	biological_process	protein stabilization
f	0070516	cellular_component	CAK-ERCC2 complex
f	0070985	cellular_component	transcription factor TFIIK complex
f	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001054	molecular_function	RNA polymerase I activity
F	0001055	molecular_function	RNA polymerase II activity
F	0001056	molecular_function	RNA polymerase III activity
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005730	cellular_component	nucleolus
F	0005736	cellular_component	RNA polymerase I complex
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
g	0000151	cellular_component	ubiquitin ligase complex
g	0001223	molecular_function	transcription coactivator binding
g	0003677	molecular_function	DNA binding
g	0003712	molecular_function	transcription coregulator activity
g	0003713	molecular_function	transcription coactivator activity
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0006357	biological_process	regulation of transcription by RNA polymerase II
g	0016020	cellular_component	membrane
g	0016567	biological_process	protein ubiquitination
g	0016592	cellular_component	mediator complex
g	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
g	0035019	biological_process	somatic stem cell population maintenance
g	0045944	biological_process	positive regulation of transcription by RNA polymerase II
g	0051123	biological_process	RNA polymerase II preinitiation complex assembly
g	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
g	0061630	molecular_function	ubiquitin protein ligase activity
g	0070847	cellular_component	core mediator complex
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005665	cellular_component	RNA polymerase II, core complex
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
h	0000151	cellular_component	ubiquitin ligase complex
h	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
h	0003712	molecular_function	transcription coregulator activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0006357	biological_process	regulation of transcription by RNA polymerase II
h	0016567	biological_process	protein ubiquitination
h	0016592	cellular_component	mediator complex
h	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
h	0051123	biological_process	RNA polymerase II preinitiation complex assembly
h	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
h	0061630	molecular_function	ubiquitin protein ligase activity
h	0070847	cellular_component	core mediator complex
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0001054	molecular_function	RNA polymerase I activity
H	0001055	molecular_function	RNA polymerase II activity
H	0001056	molecular_function	RNA polymerase III activity
H	0003677	molecular_function	DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005730	cellular_component	nucleolus
H	0005736	cellular_component	RNA polymerase I complex
H	0005829	cellular_component	cytosol
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006366	biological_process	transcription by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0032993	cellular_component	protein-DNA complex
i	0000151	cellular_component	ubiquitin ligase complex
i	0003712	molecular_function	transcription coregulator activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0006357	biological_process	regulation of transcription by RNA polymerase II
i	0016567	biological_process	protein ubiquitination
i	0016592	cellular_component	mediator complex
i	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
i	0051123	biological_process	RNA polymerase II preinitiation complex assembly
i	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
i	0061630	molecular_function	ubiquitin protein ligase activity
i	0070847	cellular_component	core mediator complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
j	0000151	cellular_component	ubiquitin ligase complex
j	0003712	molecular_function	transcription coregulator activity
j	0003713	molecular_function	transcription coactivator activity
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005667	cellular_component	transcription regulator complex
j	0006357	biological_process	regulation of transcription by RNA polymerase II
j	0006367	biological_process	transcription initiation at RNA polymerase II promoter
j	0016020	cellular_component	membrane
j	0016567	biological_process	protein ubiquitination
j	0016592	cellular_component	mediator complex
j	0030374	molecular_function	nuclear receptor coactivator activity
j	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
j	0035019	biological_process	somatic stem cell population maintenance
j	0042809	molecular_function	nuclear vitamin D receptor binding
j	0045893	biological_process	positive regulation of DNA-templated transcription
j	0045944	biological_process	positive regulation of transcription by RNA polymerase II
j	0046966	molecular_function	nuclear thyroid hormone receptor binding
j	0051123	biological_process	RNA polymerase II preinitiation complex assembly
j	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
j	0061630	molecular_function	ubiquitin protein ligase activity
j	0070847	cellular_component	core mediator complex
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001054	molecular_function	RNA polymerase I activity
J	0001055	molecular_function	RNA polymerase II activity
J	0001056	molecular_function	RNA polymerase III activity
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0005829	cellular_component	cytosol
J	0006351	biological_process	DNA-templated transcription
J	0006356	biological_process	regulation of transcription by RNA polymerase I
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
k	0000151	cellular_component	ubiquitin ligase complex
k	0003712	molecular_function	transcription coregulator activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0006357	biological_process	regulation of transcription by RNA polymerase II
k	0006369	biological_process	termination of RNA polymerase II transcription
k	0016567	biological_process	protein ubiquitination
k	0016592	cellular_component	mediator complex
k	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
k	0051123	biological_process	RNA polymerase II preinitiation complex assembly
k	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
k	0061630	molecular_function	ubiquitin protein ligase activity
k	0070847	cellular_component	core mediator complex
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0030275	molecular_function	LRR domain binding
K	0046983	molecular_function	protein dimerization activity
l	0003712	molecular_function	transcription coregulator activity
l	0003713	molecular_function	transcription coactivator activity
l	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0006351	biological_process	DNA-templated transcription
l	0006357	biological_process	regulation of transcription by RNA polymerase II
l	0006366	biological_process	transcription by RNA polymerase II
l	0016592	cellular_component	mediator complex
l	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
l	0032991	cellular_component	protein-containing complex
l	0035914	biological_process	skeletal muscle cell differentiation
l	0051123	biological_process	RNA polymerase II preinitiation complex assembly
l	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
l	0070847	cellular_component	core mediator complex
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001054	molecular_function	RNA polymerase I activity
L	0001055	molecular_function	RNA polymerase II activity
L	0001056	molecular_function	RNA polymerase III activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005829	cellular_component	cytosol
L	0006351	biological_process	DNA-templated transcription
L	0006356	biological_process	regulation of transcription by RNA polymerase I
L	0006360	biological_process	transcription by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
m	0003712	molecular_function	transcription coregulator activity
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0006357	biological_process	regulation of transcription by RNA polymerase II
m	0016592	cellular_component	mediator complex
m	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
m	0051123	biological_process	RNA polymerase II preinitiation complex assembly
m	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
m	0070847	cellular_component	core mediator complex
M	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
M	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005669	cellular_component	transcription factor TFIID complex
M	0005672	cellular_component	transcription factor TFIIA complex
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006366	biological_process	transcription by RNA polymerase II
M	0006367	biological_process	transcription initiation at RNA polymerase II promoter
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0017025	molecular_function	TBP-class protein binding
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046982	molecular_function	protein heterodimerization activity
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
M	0097550	cellular_component	transcription preinitiation complex
n	0000151	cellular_component	ubiquitin ligase complex
n	0003713	molecular_function	transcription coactivator activity
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005667	cellular_component	transcription regulator complex
n	0005730	cellular_component	nucleolus
n	0005829	cellular_component	cytosol
n	0006357	biological_process	regulation of transcription by RNA polymerase II
n	0006367	biological_process	transcription initiation at RNA polymerase II promoter
n	0016567	biological_process	protein ubiquitination
n	0016592	cellular_component	mediator complex
n	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
n	0035019	biological_process	somatic stem cell population maintenance
n	0051123	biological_process	RNA polymerase II preinitiation complex assembly
n	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
n	0061630	molecular_function	ubiquitin protein ligase activity
n	0070847	cellular_component	core mediator complex
N	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005669	cellular_component	transcription factor TFIID complex
N	0005672	cellular_component	transcription factor TFIIA complex
N	0006366	biological_process	transcription by RNA polymerase II
N	0006367	biological_process	transcription initiation at RNA polymerase II promoter
N	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
N	0017025	molecular_function	TBP-class protein binding
N	0030054	cellular_component	cell junction
N	0042803	molecular_function	protein homodimerization activity
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0046982	molecular_function	protein heterodimerization activity
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
o	0003779	molecular_function	actin binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005856	cellular_component	cytoskeleton
o	0016020	cellular_component	membrane
o	0016592	cellular_component	mediator complex
o	0030864	cellular_component	cortical actin cytoskeleton
o	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
o	0035019	biological_process	somatic stem cell population maintenance
o	0051123	biological_process	RNA polymerase II preinitiation complex assembly
o	0051151	biological_process	negative regulation of smooth muscle cell differentiation
o	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
o	0070847	cellular_component	core mediator complex
O	0000776	cellular_component	kinetochore
O	0000793	cellular_component	condensed chromosome
O	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
O	0000993	molecular_function	RNA polymerase II complex binding
O	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
O	0003677	molecular_function	DNA binding
O	0004402	molecular_function	histone acetyltransferase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005669	cellular_component	transcription factor TFIID complex
O	0005694	cellular_component	chromosome
O	0006338	biological_process	chromatin remodeling
O	0006352	biological_process	DNA-templated transcription initiation
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0006473	biological_process	protein acetylation
O	0008270	molecular_function	zinc ion binding
O	0010467	biological_process	gene expression
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0016407	molecular_function	acetyltransferase activity
O	0016604	cellular_component	nuclear body
O	0016746	molecular_function	acyltransferase activity
O	0017025	molecular_function	TBP-class protein binding
O	0019083	biological_process	viral transcription
O	0032153	cellular_component	cell division site
O	0032993	cellular_component	protein-DNA complex
O	0042585	cellular_component	germinal vesicle
O	0046872	molecular_function	metal ion binding
O	0046966	molecular_function	nuclear thyroid hormone receptor binding
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0051177	biological_process	meiotic sister chromatid cohesion
O	0051225	biological_process	spindle assembly
O	0051276	biological_process	chromosome organization
O	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
O	0070897	biological_process	transcription preinitiation complex assembly
O	0090575	cellular_component	RNA polymerase II transcription regulator complex
O	0097550	cellular_component	transcription preinitiation complex
O	0140297	molecular_function	DNA-binding transcription factor binding
O	1904798	biological_process	positive regulation of core promoter binding
O	1990114	biological_process	RNA polymerase II core complex assembly
O	1990841	molecular_function	promoter-specific chromatin binding
p	0003712	molecular_function	transcription coregulator activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0006357	biological_process	regulation of transcription by RNA polymerase II
p	0016592	cellular_component	mediator complex
p	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
p	0051123	biological_process	RNA polymerase II preinitiation complex assembly
p	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
p	0070847	cellular_component	core mediator complex
P	0000785	cellular_component	chromatin
P	0000791	cellular_component	euchromatin
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
P	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
P	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
P	0001046	molecular_function	core promoter sequence-specific DNA binding
P	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
P	0001093	molecular_function	TFIIB-class transcription factor binding
P	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
P	0001188	biological_process	RNA polymerase I preinitiation complex assembly
P	0001673	cellular_component	male germ cell nucleus
P	0001674	cellular_component	female germ cell nucleus
P	0001939	cellular_component	female pronucleus
P	0001940	cellular_component	male pronucleus
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
P	0005669	cellular_component	transcription factor TFIID complex
P	0005672	cellular_component	transcription factor TFIIA complex
P	0005737	cellular_component	cytoplasm
P	0006352	biological_process	DNA-templated transcription initiation
P	0006366	biological_process	transcription by RNA polymerase II
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0006383	biological_process	transcription by RNA polymerase III
P	0007283	biological_process	spermatogenesis
P	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
P	0017162	molecular_function	aryl hydrocarbon receptor binding
P	0019899	molecular_function	enzyme binding
P	0032991	cellular_component	protein-containing complex
P	0042789	biological_process	mRNA transcription by RNA polymerase II
P	0045120	cellular_component	pronucleus
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0140297	molecular_function	DNA-binding transcription factor binding
q	0000151	cellular_component	ubiquitin ligase complex
q	0003712	molecular_function	transcription coregulator activity
q	0003713	molecular_function	transcription coactivator activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0016567	biological_process	protein ubiquitination
q	0016592	cellular_component	mediator complex
q	0030374	molecular_function	nuclear receptor coactivator activity
q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
q	0035019	biological_process	somatic stem cell population maintenance
q	0042809	molecular_function	nuclear vitamin D receptor binding
q	0045893	biological_process	positive regulation of DNA-templated transcription
q	0046966	molecular_function	nuclear thyroid hormone receptor binding
q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
q	0061630	molecular_function	ubiquitin protein ligase activity
q	0070847	cellular_component	core mediator complex
Q	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005669	cellular_component	transcription factor TFIID complex
Q	0005673	cellular_component	transcription factor TFIIE complex
Q	0005829	cellular_component	cytosol
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Q	0046872	molecular_function	metal ion binding
r	0003712	molecular_function	transcription coregulator activity
r	0003713	molecular_function	transcription coactivator activity
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0006357	biological_process	regulation of transcription by RNA polymerase II
r	0016020	cellular_component	membrane
r	0016592	cellular_component	mediator complex
r	0030374	molecular_function	nuclear receptor coactivator activity
r	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
r	0035019	biological_process	somatic stem cell population maintenance
r	0042809	molecular_function	nuclear vitamin D receptor binding
r	0045893	biological_process	positive regulation of DNA-templated transcription
r	0045944	biological_process	positive regulation of transcription by RNA polymerase II
r	0051123	biological_process	RNA polymerase II preinitiation complex assembly
r	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
r	0070847	cellular_component	core mediator complex
R	0001097	molecular_function	TFIIH-class transcription factor complex binding
R	0003677	molecular_function	DNA binding
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005669	cellular_component	transcription factor TFIID complex
R	0005673	cellular_component	transcription factor TFIIE complex
R	0005829	cellular_component	cytosol
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
s	0003712	molecular_function	transcription coregulator activity
s	0003713	molecular_function	transcription coactivator activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0006357	biological_process	regulation of transcription by RNA polymerase II
s	0006366	biological_process	transcription by RNA polymerase II
s	0016020	cellular_component	membrane
s	0016592	cellular_component	mediator complex
s	0030374	molecular_function	nuclear receptor coactivator activity
s	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
s	0042809	molecular_function	nuclear vitamin D receptor binding
s	0045893	biological_process	positive regulation of DNA-templated transcription
s	0046966	molecular_function	nuclear thyroid hormone receptor binding
s	0051123	biological_process	RNA polymerase II preinitiation complex assembly
s	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
s	0070847	cellular_component	core mediator complex
S	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
S	0001096	molecular_function	TFIIF-class transcription factor complex binding
S	0003677	molecular_function	DNA binding
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005669	cellular_component	transcription factor TFIID complex
S	0005674	cellular_component	transcription factor TFIIF complex
S	0006366	biological_process	transcription by RNA polymerase II
S	0006367	biological_process	transcription initiation at RNA polymerase II promoter
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0009615	biological_process	response to virus
S	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
S	0019211	molecular_function	phosphatase activator activity
S	0019903	molecular_function	protein phosphatase binding
S	0019904	molecular_function	protein domain specific binding
S	0030054	cellular_component	cell junction
S	0032091	biological_process	negative regulation of protein binding
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0032991	cellular_component	protein-containing complex
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	1990841	molecular_function	promoter-specific chromatin binding
t	0000151	cellular_component	ubiquitin ligase complex
t	0003712	molecular_function	transcription coregulator activity
t	0003713	molecular_function	transcription coactivator activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005667	cellular_component	transcription regulator complex
t	0006357	biological_process	regulation of transcription by RNA polymerase II
t	0006367	biological_process	transcription initiation at RNA polymerase II promoter
t	0016567	biological_process	protein ubiquitination
t	0016592	cellular_component	mediator complex
t	0016604	cellular_component	nuclear body
t	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
t	0035019	biological_process	somatic stem cell population maintenance
t	0051123	biological_process	RNA polymerase II preinitiation complex assembly
t	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070847	cellular_component	core mediator complex
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005674	cellular_component	transcription factor TFIIF complex
T	0006366	biological_process	transcription by RNA polymerase II
T	0006367	biological_process	transcription initiation at RNA polymerase II promoter
T	0006368	biological_process	transcription elongation by RNA polymerase II
T	0015630	cellular_component	microtubule cytoskeleton
T	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
u	0003712	molecular_function	transcription coregulator activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0006357	biological_process	regulation of transcription by RNA polymerase II
u	0016592	cellular_component	mediator complex
u	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
u	0051123	biological_process	RNA polymerase II preinitiation complex assembly
u	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
u	0070847	cellular_component	core mediator complex
v	0000151	cellular_component	ubiquitin ligase complex
v	0003712	molecular_function	transcription coregulator activity
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0006357	biological_process	regulation of transcription by RNA polymerase II
v	0016567	biological_process	protein ubiquitination
v	0016592	cellular_component	mediator complex
v	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
v	0045944	biological_process	positive regulation of transcription by RNA polymerase II
v	0051123	biological_process	RNA polymerase II preinitiation complex assembly
v	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
v	0061630	molecular_function	ubiquitin protein ligase activity
v	0070847	cellular_component	core mediator complex
w	0003712	molecular_function	transcription coregulator activity
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0006357	biological_process	regulation of transcription by RNA polymerase II
w	0016592	cellular_component	mediator complex
w	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
w	0045944	biological_process	positive regulation of transcription by RNA polymerase II
w	0051123	biological_process	RNA polymerase II preinitiation complex assembly
w	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
w	0070847	cellular_component	core mediator complex
W	0000112	cellular_component	nucleotide-excision repair factor 3 complex
W	0000439	cellular_component	transcription factor TFIIH core complex
W	0000717	biological_process	nucleotide-excision repair, DNA duplex unwinding
W	0001666	biological_process	response to hypoxia
W	0003677	molecular_function	DNA binding
W	0003678	molecular_function	DNA helicase activity
W	0003684	molecular_function	damaged DNA binding
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005669	cellular_component	transcription factor TFIID complex
W	0005675	cellular_component	transcription factor TFIIH holo complex
W	0006265	biological_process	DNA topological change
W	0006281	biological_process	DNA repair
W	0006283	biological_process	transcription-coupled nucleotide-excision repair
W	0006289	biological_process	nucleotide-excision repair
W	0006366	biological_process	transcription by RNA polymerase II
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0006915	biological_process	apoptotic process
W	0006979	biological_process	response to oxidative stress
W	0008104	biological_process	protein localization
W	0009411	biological_process	response to UV
W	0009650	biological_process	UV protection
W	0016787	molecular_function	hydrolase activity
W	0016853	molecular_function	isomerase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0035315	biological_process	hair cell differentiation
W	0043065	biological_process	positive regulation of apoptotic process
W	0043138	molecular_function	3'-5' DNA helicase activity
W	0048568	biological_process	embryonic organ development
W	0097550	cellular_component	transcription preinitiation complex
W	0140640	molecular_function	catalytic activity, acting on a nucleic acid
W	1901990	biological_process	regulation of mitotic cell cycle phase transition
W	1990841	molecular_function	promoter-specific chromatin binding
x	0000151	cellular_component	ubiquitin ligase complex
x	0001824	biological_process	blastocyst development
x	0003712	molecular_function	transcription coregulator activity
x	0003713	molecular_function	transcription coactivator activity
x	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0006357	biological_process	regulation of transcription by RNA polymerase II
x	0016567	biological_process	protein ubiquitination
x	0016592	cellular_component	mediator complex
x	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
x	0035019	biological_process	somatic stem cell population maintenance
x	0045944	biological_process	positive regulation of transcription by RNA polymerase II
x	0051123	biological_process	RNA polymerase II preinitiation complex assembly
x	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
x	0061630	molecular_function	ubiquitin protein ligase activity
x	0070847	cellular_component	core mediator complex
X	0000439	cellular_component	transcription factor TFIIH core complex
X	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X	0001666	biological_process	response to hypoxia
X	0001701	biological_process	in utero embryonic development
X	0003676	molecular_function	nucleic acid binding
X	0003677	molecular_function	DNA binding
X	0003678	molecular_function	DNA helicase activity
X	0003684	molecular_function	damaged DNA binding
X	0004386	molecular_function	helicase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005669	cellular_component	transcription factor TFIID complex
X	0005675	cellular_component	transcription factor TFIIH holo complex
X	0005737	cellular_component	cytoplasm
X	0005819	cellular_component	spindle
X	0005829	cellular_component	cytosol
X	0005856	cellular_component	cytoskeleton
X	0006139	biological_process	nucleobase-containing compound metabolic process
X	0006259	biological_process	DNA metabolic process
X	0006281	biological_process	DNA repair
X	0006283	biological_process	transcription-coupled nucleotide-excision repair
X	0006289	biological_process	nucleotide-excision repair
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006362	biological_process	transcription elongation by RNA polymerase I
X	0006366	biological_process	transcription by RNA polymerase II
X	0006367	biological_process	transcription initiation at RNA polymerase II promoter
X	0006915	biological_process	apoptotic process
X	0006974	biological_process	DNA damage response
X	0006979	biological_process	response to oxidative stress
X	0007059	biological_process	chromosome segregation
X	0008340	biological_process	determination of adult lifespan
X	0009411	biological_process	response to UV
X	0009650	biological_process	UV protection
X	0009791	biological_process	post-embryonic development
X	0016787	molecular_function	hydrolase activity
X	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
X	0016853	molecular_function	isomerase activity
X	0016887	molecular_function	ATP hydrolysis activity
X	0021510	biological_process	spinal cord development
X	0022405	biological_process	hair cycle process
X	0030198	biological_process	extracellular matrix organization
X	0030282	biological_process	bone mineralization
X	0030674	molecular_function	protein-macromolecule adaptor activity
X	0032289	biological_process	central nervous system myelin formation
X	0032508	biological_process	DNA duplex unwinding
X	0035264	biological_process	multicellular organism growth
X	0035315	biological_process	hair cell differentiation
X	0040016	biological_process	embryonic cleavage
X	0042274	biological_process	ribosomal small subunit biogenesis
X	0043139	molecular_function	5'-3' DNA helicase activity
X	0043249	biological_process	erythrocyte maturation
X	0043588	biological_process	skin development
X	0045951	biological_process	positive regulation of mitotic recombination
X	0046872	molecular_function	metal ion binding
X	0048009	biological_process	insulin-like growth factor receptor signaling pathway
X	0048568	biological_process	embryonic organ development
X	0048820	biological_process	hair follicle maturation
X	0051539	molecular_function	4 iron, 4 sulfur cluster binding
X	0060218	biological_process	hematopoietic stem cell differentiation
X	0070516	cellular_component	CAK-ERCC2 complex
X	0071425	biological_process	hematopoietic stem cell proliferation
X	0071817	cellular_component	MMXD complex
X	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
X	1901990	biological_process	regulation of mitotic cell cycle phase transition
y	0000151	cellular_component	ubiquitin ligase complex
y	0003712	molecular_function	transcription coregulator activity
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0006355	biological_process	regulation of DNA-templated transcription
y	0006357	biological_process	regulation of transcription by RNA polymerase II
y	0016567	biological_process	protein ubiquitination
y	0016592	cellular_component	mediator complex
y	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
y	0048147	biological_process	negative regulation of fibroblast proliferation
y	0051123	biological_process	RNA polymerase II preinitiation complex assembly
y	0060173	biological_process	limb development
y	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
y	0061630	molecular_function	ubiquitin protein ligase activity
y	0070847	cellular_component	core mediator complex
Y	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
Y	0000439	cellular_component	transcription factor TFIIH core complex
Y	0003682	molecular_function	chromatin binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005675	cellular_component	transcription factor TFIIH holo complex
Y	0006281	biological_process	DNA repair
Y	0006289	biological_process	nucleotide-excision repair
Y	0006351	biological_process	DNA-templated transcription
Y	0006360	biological_process	transcription by RNA polymerase I
Y	0006366	biological_process	transcription by RNA polymerase II
Y	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Y	0009755	biological_process	hormone-mediated signaling pathway
Y	0045893	biological_process	positive regulation of DNA-templated transcription
Y	0046966	molecular_function	nuclear thyroid hormone receptor binding
z	0003712	molecular_function	transcription coregulator activity
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005737	cellular_component	cytoplasm
z	0006355	biological_process	regulation of DNA-templated transcription
z	0016020	cellular_component	membrane
z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
z	0035019	biological_process	somatic stem cell population maintenance
z	0051123	biological_process	RNA polymerase II preinitiation complex assembly
z	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
z	0070847	cellular_component	core mediator complex
Z	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
Z	0000439	cellular_component	transcription factor TFIIH core complex
Z	0001671	molecular_function	ATPase activator activity
Z	0003690	molecular_function	double-stranded DNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005669	cellular_component	transcription factor TFIID complex
Z	0005675	cellular_component	transcription factor TFIIH holo complex
Z	0006281	biological_process	DNA repair
Z	0006289	biological_process	nucleotide-excision repair
Z	0006366	biological_process	transcription by RNA polymerase II
Z	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Z	0016607	cellular_component	nuclear speck

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPNDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
a	CYS360-HIS380

---

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK

Chain	Residue	Details
e	LEU18-LYS42

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL

Chain	Residue	Details
e	ILE133-LEU145

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1916-LYS1922
A	TYR1629-ASN1635
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
P	TYR192-VAL241
P	TYR283-LEU332

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV

Chain	Residue	Details
d	CYS26-VAL35

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
X	ALA229-ASN238

---

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC

Chain	Residue	Details
O	GLY153-CYS168
O	GLY247-SER262

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
E	MET1
C	CYS90
C	CYS94
C	CYS97
A	ASP499
A	ARG1416
A	ARG1421

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
E	LYS81
A	ASP495
B	ASP792
A	CYS81
A	HIS84
A	CYS111
A	CYS114
A	CYS154
A	CYS184
A	ASN493

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER257
B	GLN731
B	ARG841
B	ARG890
B	LYS942
B	ARG1078
B	ARG1085

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6

Chain	Residue	Details
B	CYS1119
O	THR284
O	ARG286
O	ARG290
B	CYS1122
B	CYS1137
B	CYS1140
O	LYS189
O	LYS196
O	ARG248
O	LYS272
O	ALA281

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER937
A	SER217
A	SER1868

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
B	LYS1052

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; alternate; by PRMT5 => ECO:0000269|PubMed:26700805

Chain	Residue	Details
A	ARG1810

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
A	LYS1838
S	SER431

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:26566685

Chain	Residue	Details
A	THR1840
A	THR1933
A	THR1863
A	THR1870
A	THR1877
A	THR1912
A	THR1915
A	THR1919
A	THR1926
A	THR1929

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER1843

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685

Chain	Residue	Details
A	SER1845
A	SER1857
A	SER1861
A	SER1875

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
A	SER1847

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER1849

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1850
A	SER1864

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR1854

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:26566685

Chain	Residue	Details
A	LYS1859
A	LYS1866
A	LYS1873
A	LYS1887

---

site_id	SWS_FT_FI17
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685

Chain	Residue	Details
A	TYR1860
A	TYR1867
A	TYR1881
A	TYR1916
A	TYR1930

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR1874

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1878
A	SER1882

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1885

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
A	THR1894

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER1896

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1899

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER1906

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: N6,N6-dimethyllysine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
A	LYS1908

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR1909
A	TYR1923

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1913
A	SER1920
A	SER1927

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER1917
A	SER1931

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:26566685

Chain	Residue	Details
A	LYS1922
A	LYS1936

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1934

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4 => ECO:0000269|PubMed:32142649, ECO:0000305|PubMed:32142654

Chain	Residue	Details
A	LYS1268

---