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7LAD

Clobetasol propionate bound to CYP3A5

Functional Information from GO Data
ChainGOidnamespacecontents
A0002933biological_processlipid hydroxylation
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008210biological_processestrogen metabolic process
A0008401molecular_functionretinoic acid 4-hydroxylase activity
A0009822biological_processalkaloid catabolic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0019825molecular_functionoxygen binding
A0020037molecular_functionheme binding
A0042178biological_processxenobiotic catabolic process
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0046222biological_processaflatoxin metabolic process
A0046872molecular_functionmetal ion binding
A0050649molecular_functiontestosterone 6-beta-hydroxylase activity
A0070989biological_processoxidative demethylation
A0101020molecular_functionestrogen 16-alpha-hydroxylase activity
Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGtGPRNCIG
ChainResidueDetails
APHE434-GLY443

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS441

227111

PDB entries from 2024-11-06

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