7L9U

Crystal Structure of S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis in complex with a 12-mer PEG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008610	biological_process	lipid biosynthetic process
A	0008825	molecular_function	cyclopropane-fatty-acyl-phospholipid synthase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0071768	biological_process	mycolic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue 12P A 301

Chain	Residue
A	ILE14
A	TYR261
A	TYR264
A	CYS268
A	PHE271
A	PHE272
A	SER277
A	HOH536
A	HOH570
A	HOH600
A	TYR15
A	PHE22
A	TYR32
A	SER95
A	GLN98
A	MET185
A	ILE198
A	TYR231

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 302

Chain	Residue
A	GLU40
A	HIS230
A	ARG233

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NO3 A 303

Chain	Residue
A	THR33
A	CYS34
A	GLY136
A	GLU139
A	HIS166
A	TYR231

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NO3 A 304

Chain	Residue
A	ARG233
A	ASN236
A	ARG273
A	HOH412
A	HOH476

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 305

Chain	Residue
A	SER18
A	GLN253

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P9WPB7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P9WPB7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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