7L9T
Crystal Structure of Dihydrofolate reductase from Mycolicibacterium smegmatis in complex with SDDC-0001565 inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue QKJ A 201 |
| Chain | Residue |
| A | ILE6 |
| A | TYR98 |
| A | HOH313 |
| A | HOH338 |
| A | TRP7 |
| A | ASP28 |
| A | PHE32 |
| A | LYS33 |
| A | LEU51 |
| A | PRO52 |
| A | ARG61 |
| A | ILE92 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ARG31 |
| A | ASP121 |
| A | GLY122 |
| A | ARG125 |
| A | HOH329 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | GLY44 |
| A | ARG45 |
| A | LEU46 |
| A | THR47 |
| A | GLY94 |
| A | HOH332 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 204 |
| Chain | Residue |
| A | TRP23 |
| A | ARG24 |
| A | ARG24 |
| A | LEU25 |
| A | LEU29 |
| A | HOH318 |
