7L9P

Structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001556	biological_process	oocyte maturation
A	0001673	cellular_component	male germ cell nucleus
A	0003712	molecular_function	transcription coregulator activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006302	biological_process	double-strand break repair
A	0006366	biological_process	transcription by RNA polymerase II
A	0007094	biological_process	mitotic spindle assembly checkpoint signaling
A	0007130	biological_process	synaptonemal complex assembly
A	0007131	biological_process	reciprocal meiotic recombination
A	0007141	biological_process	male meiosis I
A	0007144	biological_process	female meiosis I
A	0007283	biological_process	spermatogenesis
A	0007286	biological_process	spermatid development
A	0016887	molecular_function	ATP hydrolysis activity
A	0030154	biological_process	cell differentiation
A	0042802	molecular_function	identical protein binding
A	0048477	biological_process	oogenesis
A	0051321	biological_process	meiotic cell cycle
A	0051598	biological_process	meiotic recombination checkpoint signaling
B	0001556	biological_process	oocyte maturation
B	0001673	cellular_component	male germ cell nucleus
B	0003712	molecular_function	transcription coregulator activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006302	biological_process	double-strand break repair
B	0006366	biological_process	transcription by RNA polymerase II
B	0007094	biological_process	mitotic spindle assembly checkpoint signaling
B	0007130	biological_process	synaptonemal complex assembly
B	0007131	biological_process	reciprocal meiotic recombination
B	0007141	biological_process	male meiosis I
B	0007144	biological_process	female meiosis I
B	0007283	biological_process	spermatogenesis
B	0007286	biological_process	spermatid development
B	0016887	molecular_function	ATP hydrolysis activity
B	0030154	biological_process	cell differentiation
B	0042802	molecular_function	identical protein binding
B	0048477	biological_process	oogenesis
B	0051321	biological_process	meiotic cell cycle
B	0051598	biological_process	meiotic recombination checkpoint signaling
C	0001556	biological_process	oocyte maturation
C	0001673	cellular_component	male germ cell nucleus
C	0003712	molecular_function	transcription coregulator activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006302	biological_process	double-strand break repair
C	0006366	biological_process	transcription by RNA polymerase II
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0007130	biological_process	synaptonemal complex assembly
C	0007131	biological_process	reciprocal meiotic recombination
C	0007141	biological_process	male meiosis I
C	0007144	biological_process	female meiosis I
C	0007283	biological_process	spermatogenesis
C	0007286	biological_process	spermatid development
C	0016887	molecular_function	ATP hydrolysis activity
C	0030154	biological_process	cell differentiation
C	0042802	molecular_function	identical protein binding
C	0048477	biological_process	oogenesis
C	0051321	biological_process	meiotic cell cycle
C	0051598	biological_process	meiotic recombination checkpoint signaling
D	0001556	biological_process	oocyte maturation
D	0001673	cellular_component	male germ cell nucleus
D	0003712	molecular_function	transcription coregulator activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006302	biological_process	double-strand break repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0007094	biological_process	mitotic spindle assembly checkpoint signaling
D	0007130	biological_process	synaptonemal complex assembly
D	0007131	biological_process	reciprocal meiotic recombination
D	0007141	biological_process	male meiosis I
D	0007144	biological_process	female meiosis I
D	0007283	biological_process	spermatogenesis
D	0007286	biological_process	spermatid development
D	0016887	molecular_function	ATP hydrolysis activity
D	0030154	biological_process	cell differentiation
D	0042802	molecular_function	identical protein binding
D	0048477	biological_process	oogenesis
D	0051321	biological_process	meiotic cell cycle
D	0051598	biological_process	meiotic recombination checkpoint signaling
E	0001556	biological_process	oocyte maturation
E	0001673	cellular_component	male germ cell nucleus
E	0003712	molecular_function	transcription coregulator activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006302	biological_process	double-strand break repair
E	0006366	biological_process	transcription by RNA polymerase II
E	0007094	biological_process	mitotic spindle assembly checkpoint signaling
E	0007130	biological_process	synaptonemal complex assembly
E	0007131	biological_process	reciprocal meiotic recombination
E	0007141	biological_process	male meiosis I
E	0007144	biological_process	female meiosis I
E	0007283	biological_process	spermatogenesis
E	0007286	biological_process	spermatid development
E	0016887	molecular_function	ATP hydrolysis activity
E	0030154	biological_process	cell differentiation
E	0042802	molecular_function	identical protein binding
E	0048477	biological_process	oogenesis
E	0051321	biological_process	meiotic cell cycle
E	0051598	biological_process	meiotic recombination checkpoint signaling
F	0001556	biological_process	oocyte maturation
F	0001673	cellular_component	male germ cell nucleus
F	0003712	molecular_function	transcription coregulator activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006302	biological_process	double-strand break repair
F	0006366	biological_process	transcription by RNA polymerase II
F	0007094	biological_process	mitotic spindle assembly checkpoint signaling
F	0007130	biological_process	synaptonemal complex assembly
F	0007131	biological_process	reciprocal meiotic recombination
F	0007141	biological_process	male meiosis I
F	0007144	biological_process	female meiosis I
F	0007283	biological_process	spermatogenesis
F	0007286	biological_process	spermatid development
F	0016887	molecular_function	ATP hydrolysis activity
F	0030154	biological_process	cell differentiation
F	0042802	molecular_function	identical protein binding
F	0048477	biological_process	oogenesis
F	0051321	biological_process	meiotic cell cycle
F	0051598	biological_process	meiotic recombination checkpoint signaling
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000785	cellular_component	chromatin
G	0001558	biological_process	regulation of cell growth
G	0002208	biological_process	somatic diversification of immunoglobulins involved in immune response
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005680	cellular_component	anaphase-promoting complex
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005819	cellular_component	spindle
G	0005856	cellular_component	cytoskeleton
G	0006281	biological_process	DNA repair
G	0006302	biological_process	double-strand break repair
G	0007015	biological_process	actin filament organization
G	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0008432	molecular_function	JUN kinase binding
G	0010628	biological_process	positive regulation of gene expression
G	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
G	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
G	0010944	biological_process	negative regulation of transcription by competitive promoter binding
G	0016035	cellular_component	zeta DNA polymerase complex
G	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
G	0035861	cellular_component	site of double-strand break
G	0042177	biological_process	negative regulation of protein catabolic process
G	0042276	biological_process	error-prone translesion synthesis
G	0042772	biological_process	DNA damage response, signal transduction resulting in transcription
G	0043247	biological_process	telomere maintenance in response to DNA damage
G	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
G	0045830	biological_process	positive regulation of isotype switching
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0051301	biological_process	cell division
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
G	1901203	biological_process	positive regulation of extracellular matrix assembly
G	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
G	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
G	2000048	biological_process	negative regulation of cell-cell adhesion mediated by cadherin
G	2000678	biological_process	negative regulation of transcription regulatory region DNA binding
G	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000785	cellular_component	chromatin
I	0001558	biological_process	regulation of cell growth
I	0002208	biological_process	somatic diversification of immunoglobulins involved in immune response
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005680	cellular_component	anaphase-promoting complex
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005819	cellular_component	spindle
I	0005856	cellular_component	cytoskeleton
I	0006281	biological_process	DNA repair
I	0006302	biological_process	double-strand break repair
I	0007015	biological_process	actin filament organization
I	0007094	biological_process	mitotic spindle assembly checkpoint signaling
I	0008432	molecular_function	JUN kinase binding
I	0010628	biological_process	positive regulation of gene expression
I	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
I	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
I	0010944	biological_process	negative regulation of transcription by competitive promoter binding
I	0016035	cellular_component	zeta DNA polymerase complex
I	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
I	0035861	cellular_component	site of double-strand break
I	0042177	biological_process	negative regulation of protein catabolic process
I	0042276	biological_process	error-prone translesion synthesis
I	0042772	biological_process	DNA damage response, signal transduction resulting in transcription
I	0043247	biological_process	telomere maintenance in response to DNA damage
I	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
I	0045830	biological_process	positive regulation of isotype switching
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0051301	biological_process	cell division
I	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
I	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
I	1901203	biological_process	positive regulation of extracellular matrix assembly
I	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
I	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
I	2000048	biological_process	negative regulation of cell-cell adhesion mediated by cadherin
I	2000678	biological_process	negative regulation of transcription regulatory region DNA binding
I	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000785	cellular_component	chromatin
J	0001558	biological_process	regulation of cell growth
J	0002208	biological_process	somatic diversification of immunoglobulins involved in immune response
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005680	cellular_component	anaphase-promoting complex
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005819	cellular_component	spindle
J	0005856	cellular_component	cytoskeleton
J	0006281	biological_process	DNA repair
J	0006302	biological_process	double-strand break repair
J	0007015	biological_process	actin filament organization
J	0007094	biological_process	mitotic spindle assembly checkpoint signaling
J	0008432	molecular_function	JUN kinase binding
J	0010628	biological_process	positive regulation of gene expression
J	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
J	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
J	0010944	biological_process	negative regulation of transcription by competitive promoter binding
J	0016035	cellular_component	zeta DNA polymerase complex
J	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
J	0035861	cellular_component	site of double-strand break
J	0042177	biological_process	negative regulation of protein catabolic process
J	0042276	biological_process	error-prone translesion synthesis
J	0042772	biological_process	DNA damage response, signal transduction resulting in transcription
J	0043247	biological_process	telomere maintenance in response to DNA damage
J	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
J	0045830	biological_process	positive regulation of isotype switching
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0051301	biological_process	cell division
J	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
J	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
J	1901203	biological_process	positive regulation of extracellular matrix assembly
J	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
J	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
J	2000048	biological_process	negative regulation of cell-cell adhesion mediated by cadherin
J	2000678	biological_process	negative regulation of transcription regulatory region DNA binding
J	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000785	cellular_component	chromatin
K	0001558	biological_process	regulation of cell growth
K	0002208	biological_process	somatic diversification of immunoglobulins involved in immune response
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005680	cellular_component	anaphase-promoting complex
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005819	cellular_component	spindle
K	0005856	cellular_component	cytoskeleton
K	0006281	biological_process	DNA repair
K	0006302	biological_process	double-strand break repair
K	0007015	biological_process	actin filament organization
K	0007094	biological_process	mitotic spindle assembly checkpoint signaling
K	0008432	molecular_function	JUN kinase binding
K	0010628	biological_process	positive regulation of gene expression
K	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
K	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
K	0010944	biological_process	negative regulation of transcription by competitive promoter binding
K	0016035	cellular_component	zeta DNA polymerase complex
K	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
K	0035861	cellular_component	site of double-strand break
K	0042177	biological_process	negative regulation of protein catabolic process
K	0042276	biological_process	error-prone translesion synthesis
K	0042772	biological_process	DNA damage response, signal transduction resulting in transcription
K	0043247	biological_process	telomere maintenance in response to DNA damage
K	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
K	0045830	biological_process	positive regulation of isotype switching
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0051301	biological_process	cell division
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	1901203	biological_process	positive regulation of extracellular matrix assembly
K	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
K	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
K	2000048	biological_process	negative regulation of cell-cell adhesion mediated by cadherin
K	2000678	biological_process	negative regulation of transcription regulatory region DNA binding
K	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
X	0010569	biological_process	regulation of double-strand break repair via homologous recombination
Y	0010569	biological_process	regulation of double-strand break repair via homologous recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue AGS A 901

Chain	Residue
A	SER138
A	PRO322
A	GLY385
A	ARG386
A	LEU139
A	TYR141
A	PRO181
A	GLY182
A	GLY184
A	LYS185
A	THR186
A	SER187

---

site_id	AC2
Number of Residues	15
Details	binding site for residue AGS B 901

Chain	Residue
B	LEU139
B	VAL140
B	PRO181
B	GLY184
B	LYS185
B	THR186
B	SER187
B	GLN253
B	ASN300
B	ILE330
B	GLY385
B	ARG386
B	ARG389
C	ALA308
C	ARG312

---

site_id	AC3
Number of Residues	11
Details	binding site for residue AGS C 901

Chain	Residue
C	VAL140
C	PRO181
C	GLY182
C	THR183
C	GLY184
C	LYS185
C	THR186
C	ILE330
C	ARG386
C	ARG389
D	ARG312

---

site_id	AC4
Number of Residues	8
Details	binding site for residue AGS D 901

Chain	Residue
D	VAL140
D	THR183
D	GLY184
D	LYS185
D	THR186
D	GLY385
D	ARG386
D	ARG389

---

site_id	AC5
Number of Residues	9
Details	binding site for residue AGS E 901

Chain	Residue
E	VAL140
E	GLY182
E	THR183
E	GLY184
E	LYS185
E	THR186
E	SER187
E	ASN300
E	ARG389

---

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. VvILtTSNitekIDvAFvdR

Chain	Residue	Details
A	VAL293-ARG312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY179
B	GLY179
C	GLY179
D	GLY179
E	GLY179
F	GLY179

---