Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7L18

Crystal structure of a tandem deletion mutant of rat NADPH-cytochrome P450 reductase

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0003420	biological_process	regulation of growth plate cartilage chondrocyte proliferation
AAA	0003958	molecular_function	NADPH-hemoprotein reductase activity
AAA	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
AAA	0005737	cellular_component	cytoplasm
AAA	0005783	cellular_component	endoplasmic reticulum
AAA	0005789	cellular_component	endoplasmic reticulum membrane
AAA	0005829	cellular_component	cytosol
AAA	0007584	biological_process	response to nutrient
AAA	0008941	molecular_function	nitric oxide dioxygenase NAD(P)H activity
AAA	0009055	molecular_function	electron transfer activity
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0009437	biological_process	carnitine metabolic process
AAA	0009725	biological_process	response to hormone
AAA	0009812	biological_process	flavonoid metabolic process
AAA	0010181	molecular_function	FMN binding
AAA	0016020	cellular_component	membrane
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0016787	molecular_function	hydrolase activity
AAA	0019395	biological_process	fatty acid oxidation
AAA	0019899	molecular_function	enzyme binding
AAA	0022900	biological_process	electron transport chain
AAA	0032332	biological_process	positive regulation of chondrocyte differentiation
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0043231	cellular_component	intracellular membrane-bounded organelle
AAA	0043602	biological_process	nitrate catabolic process
AAA	0045542	biological_process	positive regulation of cholesterol biosynthetic process
AAA	0045880	biological_process	positive regulation of smoothened signaling pathway
AAA	0046210	biological_process	nitric oxide catabolic process
AAA	0047726	molecular_function	iron-cytochrome-c reductase activity
AAA	0050660	molecular_function	flavin adenine dinucleotide binding
AAA	0050661	molecular_function	NADP binding
AAA	0070988	biological_process	demethylation
AAA	0071371	biological_process	cellular response to gonadotropin stimulus
AAA	0071372	biological_process	cellular response to follicle-stimulating hormone stimulus
AAA	0071375	biological_process	cellular response to peptide hormone stimulus
AAA	0071548	biological_process	response to dexamethasone
AAA	0090031	biological_process	positive regulation of steroid hormone biosynthetic process
AAA	0090181	biological_process	regulation of cholesterol metabolic process
AAA	0090346	biological_process	cellular organofluorine metabolic process
BBB	0003420	biological_process	regulation of growth plate cartilage chondrocyte proliferation
BBB	0003958	molecular_function	NADPH-hemoprotein reductase activity
BBB	0004128	molecular_function	cytochrome-b5 reductase activity, acting on NAD(P)H
BBB	0005737	cellular_component	cytoplasm
BBB	0005783	cellular_component	endoplasmic reticulum
BBB	0005789	cellular_component	endoplasmic reticulum membrane
BBB	0005829	cellular_component	cytosol
BBB	0007584	biological_process	response to nutrient
BBB	0008941	molecular_function	nitric oxide dioxygenase NAD(P)H activity
BBB	0009055	molecular_function	electron transfer activity
BBB	0009410	biological_process	response to xenobiotic stimulus
BBB	0009437	biological_process	carnitine metabolic process
BBB	0009725	biological_process	response to hormone
BBB	0009812	biological_process	flavonoid metabolic process
BBB	0010181	molecular_function	FMN binding
BBB	0016020	cellular_component	membrane
BBB	0016491	molecular_function	oxidoreductase activity
BBB	0016787	molecular_function	hydrolase activity
BBB	0019395	biological_process	fatty acid oxidation
BBB	0019899	molecular_function	enzyme binding
BBB	0022900	biological_process	electron transport chain
BBB	0032332	biological_process	positive regulation of chondrocyte differentiation
BBB	0043066	biological_process	negative regulation of apoptotic process
BBB	0043231	cellular_component	intracellular membrane-bounded organelle
BBB	0043602	biological_process	nitrate catabolic process
BBB	0045542	biological_process	positive regulation of cholesterol biosynthetic process
BBB	0045880	biological_process	positive regulation of smoothened signaling pathway
BBB	0046210	biological_process	nitric oxide catabolic process
BBB	0047726	molecular_function	iron-cytochrome-c reductase activity
BBB	0050660	molecular_function	flavin adenine dinucleotide binding
BBB	0050661	molecular_function	NADP binding
BBB	0070988	biological_process	demethylation
BBB	0071371	biological_process	cellular response to gonadotropin stimulus
BBB	0071372	biological_process	cellular response to follicle-stimulating hormone stimulus
BBB	0071375	biological_process	cellular response to peptide hormone stimulus
BBB	0071548	biological_process	response to dexamethasone
BBB	0090031	biological_process	positive regulation of steroid hormone biosynthetic process
BBB	0090181	biological_process	regulation of cholesterol metabolic process
BBB	0090346	biological_process	cellular organofluorine metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03212, ECO:0000269\|PubMed:11371558, ECO:0000269\|PubMed:19171935, ECO:0000269\|PubMed:21345800, ECO:0000269\|PubMed:9237990, ECO:0000269\|Ref.8

Chain	Residue	Details
AAA	SER86
BBB	SER86
BBB	ALA138
BBB	LEU173
BBB	ARG454
BBB	TYR478
BBB	GLY488
BBB	THR535
BBB	SER596
BBB	LYS602
AAA	ALA138
AAA	LEU173
AAA	ARG454
AAA	TYR478
AAA	GLY488
AAA	THR535
AAA	SER596
AAA	LYS602

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03212, ECO:0000269\|PubMed:11371558, ECO:0000269\|PubMed:21345800, ECO:0000269\|PubMed:9237990

Chain	Residue	Details
AAA	ASP208
BBB	ASP208

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03212, ECO:0000269\|PubMed:11371558, ECO:0000269\|PubMed:19171935, ECO:0000269\|PubMed:21345800, ECO:0000269\|PubMed:9237990

Chain	Residue	Details
AAA	ARG298
AAA	ASP639
BBB	ARG298
BBB	ASP639

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03212, ECO:0000269\|PubMed:11371558, ECO:0000269\|PubMed:19171935, ECO:0000269\|PubMed:21345800, ECO:0000269\|Ref.8

Chain	Residue	Details
AAA	ARG424
BBB	ARG424

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03212, ECO:0000269\|PubMed:11371558, ECO:0000269\|PubMed:19171935, ECO:0000269\|PubMed:9237990, ECO:0000269\|Ref.8

Chain	Residue	Details
AAA	CYS472
BBB	CYS472

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 117

Chain	Residue	Details
AAA	SER457	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, radical stabiliser
AAA	CYS630	electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay, steric role, van der waals interaction
AAA	TRP677	hydrogen bond acceptor, modifies pKa

site_id	MCSA2
Number of Residues	4
Details	M-CSA 117

Chain	Residue	Details
BBB	SER457	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay, radical stabiliser
BBB	CYS630	electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay, steric role, van der waals interaction
BBB	TRP677	hydrogen bond acceptor, modifies pKa

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)