Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7KSO

Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000792cellular_componentheterochromatin
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0008168molecular_functionmethyltransferase activity
A0009653biological_processanatomical structure morphogenesis
A0021766biological_processhippocampus development
A0031491molecular_functionnucleosome binding
A0031507biological_processheterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0032259biological_processmethylation
A0035098cellular_componentESC/E(Z) complex
A0042054molecular_functionhistone methyltransferase activity
A0042393molecular_functionhistone binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046976molecular_functionhistone H3K27 methyltransferase activity
A0140693molecular_functionmolecular condensate scaffold activity
A0140951molecular_functionhistone H3K27 trimethyltransferase activity
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001222molecular_functiontranscription corepressor binding
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0008047molecular_functionenzyme activator activity
B0021510biological_processspinal cord development
B0031491molecular_functionnucleosome binding
B0031507biological_processheterochromatin formation
B0035098cellular_componentESC/E(Z) complex
B0042054molecular_functionhistone methyltransferase activity
B0042802molecular_functionidentical protein binding
B0045892biological_processnegative regulation of DNA-templated transcription
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0001222molecular_functiontranscription corepressor binding
C0001739cellular_componentsex chromatin
C0003682molecular_functionchromatin binding
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005677cellular_componentchromatin silencing complex
C0005730cellular_componentnucleolus
C0006325biological_processchromatin organization
C0008047molecular_functionenzyme activator activity
C0008283biological_processcell population proliferation
C0008284biological_processpositive regulation of cell population proliferation
C0016586cellular_componentRSC-type complex
C0016604cellular_componentnuclear body
C0031490molecular_functionchromatin DNA binding
C0032993cellular_componentprotein-DNA complex
C0035064molecular_functionmethylated histone binding
C0035098cellular_componentESC/E(Z) complex
C0042054molecular_functionhistone methyltransferase activity
C0043565molecular_functionsequence-specific DNA binding
C0045596biological_processnegative regulation of cell differentiation
C0046872molecular_functionmetal ion binding
C0048709biological_processoligodendrocyte differentiation
C0060816biological_processrandom inactivation of X chromosome
C0106222molecular_functionlncRNA binding
C0140718biological_processfacultative heterochromatin formation
C1990841molecular_functionpromoter-specific chromatin binding
C1990904cellular_componentribonucleoprotein complex
D0000118cellular_componenthistone deacetylase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005829cellular_componentcytosol
D0006260biological_processDNA replication
D0006325biological_processchromatin organization
D0006334biological_processnucleosome assembly
D0006335biological_processDNA replication-dependent chromatin assembly
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0007420biological_processbrain development
D0008094molecular_functionATP-dependent activity, acting on DNA
D0008285biological_processnegative regulation of cell population proliferation
D0016581cellular_componentNuRD complex
D0016589cellular_componentNURF complex
D0030336biological_processnegative regulation of cell migration
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0031492molecular_functionnucleosomal DNA binding
D0032991cellular_componentprotein-containing complex
D0033186cellular_componentCAF-1 complex
D0035098cellular_componentESC/E(Z) complex
D0042393molecular_functionhistone binding
D0042659biological_processregulation of cell fate specification
D0042826molecular_functionhistone deacetylase binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0070822cellular_componentSin3-type complex
D1902455biological_processnegative regulation of stem cell population maintenance
D1902459biological_processpositive regulation of stem cell population maintenance
D1904949cellular_componentATPase complex
D2000736biological_processregulation of stem cell differentiation
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000785cellular_componentchromatin
F0001889biological_processliver development
F0003677molecular_functionDNA binding
F0003682molecular_functionchromatin binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005739cellular_componentmitochondrion
F0006325biological_processchromatin organization
F0006338biological_processchromatin remodeling
F0007417biological_processcentral nervous system development
F0008283biological_processcell population proliferation
F0010468biological_processregulation of gene expression
F0010614biological_processnegative regulation of cardiac muscle hypertrophy
F0030154biological_processcell differentiation
F0032452molecular_functionhistone demethylase activity
F0035097cellular_componenthistone methyltransferase complex
F0035098cellular_componentESC/E(Z) complex
F0042127biological_processregulation of cell population proliferation
F0043130molecular_functionubiquitin binding
F0045892biological_processnegative regulation of DNA-templated transcription
F0046976molecular_functionhistone H3K27 methyltransferase activity
F0048536biological_processspleen development
F0048538biological_processthymus development
F0048863biological_processstem cell differentiation
F0060038biological_processcardiac muscle cell proliferation
F0060044biological_processnegative regulation of cardiac muscle cell proliferation
F0060816biological_processrandom inactivation of X chromosome
F0061649molecular_functionubiquitin-modified histone reader activity
F0140718biological_processfacultative heterochromatin formation
F1902682biological_processprotein localization to pericentric heterochromatin
F1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues24
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H
ChainResidueDetails
ECYS263-HIS286
ECYS330-HIS352
CCYS450-HIS471

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
BLEU206-ILE220
DLEU193-ILE207
DLEU289-LEU303
DLEU333-LEU347

site_idPS00729
Number of Residues9
DetailsAP_NUCLEASE_F2_1 AP endonucleases family 2 signature 1. HGtYFNNFC
ChainResidueDetails
AHIS446-CYS454

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
FSER78

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS378

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER455
CSER541
CSER726

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ESER210
ESER211
BLYS268
BLYS284

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
ESER390

site_idSWS_FT_FI6
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
DLYS4
CLYS73

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS160
CLYS390

site_idSWS_FT_FI8
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS75

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon