7KQK
anti-pTau C21-ABS Fab in complex with pTau peptide
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| B | TYR189-HIS195 | |
| A | TYR208-HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| C | LYS224 | |
| P | LYS224 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| C | LYS225 | |
| P | LYS225 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | TPO231 | |
| P | TPO231 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| C | LYS225 | |
| P | LYS225 |
