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7KP4

Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005198molecular_functionstructural molecule activity
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005923cellular_componentbicellular tight junction
A0006821biological_processchloride transport
A0007155biological_processcell adhesion
A0007565biological_processfemale pregnancy
A0007623biological_processcircadian rhythm
A0009925cellular_componentbasal plasma membrane
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016327cellular_componentapicolateral plasma membrane
A0016328cellular_componentlateral plasma membrane
A0016338biological_processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
A0022604biological_processregulation of cell morphogenesis
A0030335biological_processpositive regulation of cell migration
A0032570biological_processresponse to progesterone
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0042802molecular_functionidentical protein binding
A0061436biological_processestablishment of skin barrier
A0070160cellular_componenttight junction
A0070293biological_processrenal absorption
A0070830biological_processbicellular tight junction assembly
A0090303biological_processpositive regulation of wound healing
A1902476biological_processchloride transmembrane transport
A1905050biological_processpositive regulation of metallopeptidase activity
B0005576cellular_componentextracellular region
Functional Information from PROSITE/UniProt
site_idPS01346
Number of Residues16
DetailsCLAUDIN Claudin family signature. GLWmnCvvqstgqm.QC
ChainResidueDetails
AGLY49-CYS64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues47
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-GLN7
ALYS103-THR117
ACYS182-VAL209

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AVAL8-PRO28
AALA82-GLY102
AMET118-TRP138
AGLY161-LEU181

site_idSWS_FT_FI3
Number of Residues73
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AMET29-ARG81
ATHR139-MET160

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by EPHA2 => ECO:0000269|PubMed:16236711
ChainResidueDetails
ATYR208

221051

PDB entries from 2024-06-12

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