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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7KNU

CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle

Functional Information from GO Data
ChainGOidnamespacecontents
E0001525biological_processangiogenesis
E0001635molecular_functioncalcitonin gene-related peptide receptor activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006816biological_processcalcium ion transport
E0006886biological_processintracellular protein transport
E0007186biological_processG protein-coupled receptor signaling pathway
E0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
E0008277biological_processregulation of G protein-coupled receptor signaling pathway
E0009986cellular_componentcell surface
E0015026molecular_functioncoreceptor activity
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0031623biological_processreceptor internalization
E0032870biological_processcellular response to hormone stimulus
E0043235cellular_componentreceptor complex
E0060050biological_processpositive regulation of protein glycosylation
E0072659biological_processprotein localization to plasma membrane
E0097643molecular_functionamylin receptor activity
E0097647biological_processamylin receptor signaling pathway
E0150059biological_processamylin receptor 1 signaling pathway
E1990406cellular_componentCGRP receptor complex
E1990407molecular_functioncalcitonin gene-related peptide binding
E1990408biological_processcalcitonin gene-related peptide receptor signaling pathway
P0005179molecular_functionhormone activity
P0005576cellular_componentextracellular region
R0004888molecular_functiontransmembrane signaling receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0004948molecular_functioncalcitonin receptor activity
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00258
Number of Residues15
DetailsCALCITONIN Calcitonin / CGRP / IAPP family signature. CDT.ATCVthrLaglL
ChainResidueDetails
PCYS2-LEU16
site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWndVaagtesmqlCP
ChainResidueDetails
RCYS65-PRO89
site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLLVsTIFCFfNgeV
ChainResidueDetails
RGLN376-VAL391
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"33602864","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KNU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phenylalanine amide","evidences":[{"source":"PubMed","id":"6609312","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues23
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues25
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UUN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsRegion: {"description":"Required for RAMP3 interaction","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsSite: {"description":"Required for ADM interaction","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsSite: {"description":"Required for RAMP3 interaction","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsSite: {"description":"Required for ADM2 interaction","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsSite: {"description":"Required for RAMP2 interaction","evidences":[{"source":"PubMed","id":"32296767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-08-27

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