7KME

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2711.

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H 950

Chain	Residue
H	LYS169
H	THR172
H	PHE204
H	HOH493
H	HOH495
H	HOH535

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H 951

Chain	Residue
H	ARG221
H	LYS224
H	HOH492
H	HOH522
H	HOH531
H	HOH548

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site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR CHAIN J OF SEL2711

Chain	Residue
H	HIS57
H	GLU97
H	LEU99
H	ILE174
H	ASP189
H	ALA190
H	GLU192
H	SER195
H	SER214
H	TRP215
H	GLY216
H	GLY219
H	HOH438

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site_id	CAT
Number of Residues	3
Details	CATALYTIC SITE

Chain	Residue
H	HIS57
H	ASP102
H	SER195

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923

Chain	Residue	Details
H	ASN60

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