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7KJR

Cryo-EM structure of SARS-CoV-2 ORF3a

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0005891cellular_componentvoltage-gated calcium channel complex
A0006811biological_processmonoatomic ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009898cellular_componentcytoplasmic side of plasma membrane
A0016020cellular_componentmembrane
A0020002cellular_componenthost cell plasma membrane
A0030430cellular_componenthost cell cytoplasm
A0033644cellular_componenthost cell membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0039520biological_processinduction by virus of host autophagy
A0042802molecular_functionidentical protein binding
A0044165cellular_componenthost cell endoplasmic reticulum
A0044167cellular_componenthost cell endoplasmic reticulum membrane
A0044174cellular_componenthost cell endosome
A0044187cellular_componenthost cell lysosome
A0044423cellular_componentvirion component
A0051259biological_processprotein complex oligomerization
A0055036cellular_componentvirion membrane
A0098662biological_processinorganic cation transmembrane transport
A0140677molecular_functionmolecular function activator activity
A0140883biological_processinduction by virus of host reticulophagy
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0005891cellular_componentvoltage-gated calcium channel complex
B0006811biological_processmonoatomic ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0009898cellular_componentcytoplasmic side of plasma membrane
B0016020cellular_componentmembrane
B0020002cellular_componenthost cell plasma membrane
B0030430cellular_componenthost cell cytoplasm
B0033644cellular_componenthost cell membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0039520biological_processinduction by virus of host autophagy
B0042802molecular_functionidentical protein binding
B0044165cellular_componenthost cell endoplasmic reticulum
B0044167cellular_componenthost cell endoplasmic reticulum membrane
B0044174cellular_componenthost cell endosome
B0044187cellular_componenthost cell lysosome
B0044423cellular_componentvirion component
B0051259biological_processprotein complex oligomerization
B0055036cellular_componentvirion membrane
B0098662biological_processinorganic cation transmembrane transport
B0140677molecular_functionmolecular function activator activity
B0140883biological_processinduction by virus of host reticulophagy
C0005576cellular_componentextracellular region
C0006869biological_processlipid transport
C0008289molecular_functionlipid binding
C0042157biological_processlipoprotein metabolic process
D0005576cellular_componentextracellular region
D0006869biological_processlipid transport
D0008289molecular_functionlipid binding
D0042157biological_processlipoprotein metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue PEE A 301
ChainResidue
ALYS61
AILE62
AILE63
ATHR64
AHOH402
BARG122
BTYR206
CTHR36
CTRP40

site_idAC2
Number of Residues9
Detailsbinding site for residue PEE B 301
ChainResidue
AARG122
ATYR206
BLYS61
BILE62
BILE63
BTHR64
BHOH404
DTHR36
DTRP40

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Methionine sulfoxide => ECO:0000269|PubMed:12576517
ChainResidueDetails
CMET54
CMET80
DMET54
DMET80

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:8261628
ChainResidueDetails
CLYS207
DLYS207
AGLU102-ARG126
BPHE43-LYS61
BARG68-HIS93
BGLU102-ARG126

site_idSWS_FT_FI3
Number of Residues306
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34158638
ChainResidueDetails
AILE62-LYS67
ALEU127-LEU275
BILE62-LYS67
BLEU127-LEU275

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Involved in polymerization => ECO:0000250|UniProtKB:P59632
ChainResidueDetails
ACYS133
BCYS133

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) threonine; by host => ECO:0000250|UniProtKB:P59632
ChainResidueDetails
ATHR32
BTHR32

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) threonine; by host => ECO:0000255
ChainResidueDetails
ATHR34
BTHR34

218853

PDB entries from 2024-04-24

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