7KHN

NicA2 variant N462Y/W427Y in complex with (S)-nicotine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	37
Details	binding site for residue FAD A 501

Chain	Residue
A	VAL59
A	GLY89
A	GLY90
A	ARG91
A	THR92
A	GLY106
A	ALA107
A	TRP108
A	PRO278
A	VAL279
A	VAL308
A	GLY60
A	PRO309
A	ILE316
A	PHE422
A	TYR427
A	GLY452
A	ALA453
A	ALA461
A	TYR462
A	ILE463
A	ALA466
A	GLY61
A	NCT502
A	HOH606
A	HOH622
A	HOH634
A	HOH637
A	HOH639
A	HOH645
A	HOH660
A	GLY62
A	PHE63
A	ALA64
A	GLU83
A	ALA84
A	ARG85

---

site_id	AC2
Number of Residues	8
Details	binding site for residue NCT A 502

Chain	Residue
A	LEU217
A	TYR218
A	TRP364
A	THR381
A	TYR427
A	ALA461
A	FAD501
A	HOH628

---

site_id	AC3
Number of Residues	8
Details	binding site for residue NCT A 503

Chain	Residue
A	GLY156
A	TYR214
A	MET246
A	GLU249
A	PHE355
A	TRP364
A	HOH610
A	HOH677

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C4A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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