7KHN
NicA2 variant N462Y/W427Y in complex with (S)-nicotine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | VAL59 |
| A | GLY89 |
| A | GLY90 |
| A | ARG91 |
| A | THR92 |
| A | GLY106 |
| A | ALA107 |
| A | TRP108 |
| A | PRO278 |
| A | VAL279 |
| A | VAL308 |
| A | GLY60 |
| A | PRO309 |
| A | ILE316 |
| A | PHE422 |
| A | TYR427 |
| A | GLY452 |
| A | ALA453 |
| A | ALA461 |
| A | TYR462 |
| A | ILE463 |
| A | ALA466 |
| A | GLY61 |
| A | NCT502 |
| A | HOH606 |
| A | HOH622 |
| A | HOH634 |
| A | HOH637 |
| A | HOH639 |
| A | HOH645 |
| A | HOH660 |
| A | GLY62 |
| A | PHE63 |
| A | ALA64 |
| A | GLU83 |
| A | ALA84 |
| A | ARG85 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue NCT A 502 |
| Chain | Residue |
| A | LEU217 |
| A | TYR218 |
| A | TRP364 |
| A | THR381 |
| A | TYR427 |
| A | ALA461 |
| A | FAD501 |
| A | HOH628 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue NCT A 503 |
| Chain | Residue |
| A | GLY156 |
| A | TYR214 |
| A | MET246 |
| A | GLU249 |
| A | PHE355 |
| A | TRP364 |
| A | HOH610 |
| A | HOH677 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:32873764, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C49, ECO:0007744|PDB:7C4A, ECO:0007744|PDB:7KHN, ECO:0007744|PDB:7KHO |
| Chain | Residue | Details |
| A | ALA64 | |
| A | GLU83 | |
| A | ARG91 | |
| A | VAL279 | |
| A | ALA453 | |
| A | ILE463 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:7KHN |
| Chain | Residue | Details |
| A | ALA84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:32873764, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:7C49, ECO:0007744|PDB:7C4A |
| Chain | Residue | Details |
| A | ARG85 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:32873764, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C4A, ECO:0007744|PDB:7KHN, ECO:0007744|PDB:7KHO |
| Chain | Residue | Details |
| A | TRP108 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C49, ECO:0007744|PDB:7KHN, ECO:0007744|PDB:7KHO |
| Chain | Residue | Details |
| A | THR381 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:32873764, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C49 |
| Chain | Residue | Details |
| A | TYR462 |
