7KGV
Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003333 | biological_process | amino acid transmembrane transport |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005770 | cellular_component | late endosome |
| A | 0006110 | biological_process | regulation of glycolytic process |
| A | 0006111 | biological_process | regulation of gluconeogenesis |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006865 | biological_process | amino acid transport |
| A | 0006867 | biological_process | asparagine transport |
| A | 0006868 | biological_process | glutamine transport |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| A | 0015182 | molecular_function | L-asparagine transmembrane transporter activity |
| A | 0015186 | molecular_function | L-glutamine transmembrane transporter activity |
| A | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| A | 0015485 | molecular_function | cholesterol binding |
| A | 0015820 | biological_process | L-leucine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0032008 | biological_process | positive regulation of TOR signaling |
| A | 0032935 | molecular_function | sterol sensor activity |
| A | 0034618 | molecular_function | arginine binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061459 | molecular_function | L-arginine transmembrane transporter activity |
| A | 0071230 | biological_process | cellular response to amino acid stimulus |
| A | 0071986 | cellular_component | Ragulator complex |
| A | 0140785 | molecular_function | amino acid sensor activity |
| A | 1900037 | biological_process | regulation of cellular response to hypoxia |
| A | 1903826 | biological_process | L-arginine transmembrane transport |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005770 | cellular_component | late endosome |
| B | 0006110 | biological_process | regulation of glycolytic process |
| B | 0006111 | biological_process | regulation of gluconeogenesis |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006865 | biological_process | amino acid transport |
| B | 0006867 | biological_process | asparagine transport |
| B | 0006868 | biological_process | glutamine transport |
| B | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015182 | molecular_function | L-asparagine transmembrane transporter activity |
| B | 0015186 | molecular_function | L-glutamine transmembrane transporter activity |
| B | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| B | 0015485 | molecular_function | cholesterol binding |
| B | 0015820 | biological_process | L-leucine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0032008 | biological_process | positive regulation of TOR signaling |
| B | 0032935 | molecular_function | sterol sensor activity |
| B | 0034618 | molecular_function | arginine binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061459 | molecular_function | L-arginine transmembrane transporter activity |
| B | 0071230 | biological_process | cellular response to amino acid stimulus |
| B | 0071986 | cellular_component | Ragulator complex |
| B | 0140785 | molecular_function | amino acid sensor activity |
| B | 1900037 | biological_process | regulation of cellular response to hypoxia |
| B | 1903826 | biological_process | L-arginine transmembrane transport |
| B | 1904263 | biological_process | positive regulation of TORC1 signaling |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| E | TYR195-HIS201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 106 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for arginine binding and amino acid transport","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Motif: {"description":"CARC motif","evidences":[{"source":"UniProtKB","id":"Q8NBW4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 12 |
| Details | Motif: {"description":"CRAC motif","evidences":[{"source":"UniProtKB","id":"Q8NBW4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C08","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 16 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29872228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
