7KF4
Crystal structure from SARS-CoV-2 NendoU NSP15
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue CIT A 700 |
Chain | Residue |
A | HIS234 |
A | GLN244 |
A | LEU245 |
A | GLY246 |
A | GLY247 |
A | HIS249 |
A | LYS289 |
A | THR340 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue CIT B 700 |
Chain | Residue |
B | LEU245 |
B | GLY246 |
B | GLY247 |
B | HIS249 |
B | LYS289 |
B | THR340 |
B | HIS234 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue CIT C 700 |
Chain | Residue |
C | HIS234 |
C | GLN244 |
C | LEU245 |
C | GLY246 |
C | GLY247 |
C | HIS249 |
C | LYS289 |
C | THR340 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue CIT D 700 |
Chain | Residue |
D | HIS234 |
D | LEU245 |
D | GLY246 |
D | GLY247 |
D | HIS249 |
D | LYS289 |
D | THR340 |
D | HOH812 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue CIT E 700 |
Chain | Residue |
E | HIS234 |
E | GLN244 |
E | LEU245 |
E | GLY246 |
E | GLY247 |
E | HIS249 |
E | LYS289 |
E | THR340 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue CIT F 700 |
Chain | Residue |
F | HIS234 |
F | GLN244 |
F | LEU245 |
F | GLY246 |
F | GLY247 |
F | HIS249 |
F | LYS289 |
F | THR340 |
F | TYR342 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | HIS234 | |
B | HIS234 | |
C | HIS234 | |
D | HIS234 | |
E | HIS234 | |
F | HIS234 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | HIS249 | |
B | HIS249 | |
C | HIS249 | |
D | HIS249 | |
E | HIS249 | |
F | HIS249 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
Chain | Residue | Details |
A | LYS289 | |
B | LYS289 | |
C | LYS289 | |
D | LYS289 | |
E | LYS289 | |
F | LYS289 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | LYS289 | |
B | LYS289 | |
C | LYS289 | |
D | LYS289 | |
E | LYS289 | |
F | LYS289 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | THR340 | |
B | THR340 | |
C | THR340 | |
D | THR340 | |
E | THR340 | |
F | THR340 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | LYS289 | |
B | LYS289 | |
C | LYS289 | |
D | LYS289 | |
E | LYS289 | |
F | LYS289 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | SER293 | |
B | SER293 | |
C | SER293 | |
D | SER293 | |
E | SER293 | |
F | SER293 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
Chain | Residue | Details |
A | GLN346 | |
B | GLN346 | |
C | GLN346 | |
D | GLN346 | |
E | GLN346 | |
F | GLN346 |