7KF4
Crystal structure from SARS-CoV-2 NendoU NSP15
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue CIT A 700 |
| Chain | Residue |
| A | HIS234 |
| A | GLN244 |
| A | LEU245 |
| A | GLY246 |
| A | GLY247 |
| A | HIS249 |
| A | LYS289 |
| A | THR340 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CIT B 700 |
| Chain | Residue |
| B | LEU245 |
| B | GLY246 |
| B | GLY247 |
| B | HIS249 |
| B | LYS289 |
| B | THR340 |
| B | HIS234 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue CIT C 700 |
| Chain | Residue |
| C | HIS234 |
| C | GLN244 |
| C | LEU245 |
| C | GLY246 |
| C | GLY247 |
| C | HIS249 |
| C | LYS289 |
| C | THR340 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue CIT D 700 |
| Chain | Residue |
| D | HIS234 |
| D | LEU245 |
| D | GLY246 |
| D | GLY247 |
| D | HIS249 |
| D | LYS289 |
| D | THR340 |
| D | HOH812 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue CIT E 700 |
| Chain | Residue |
| E | HIS234 |
| E | GLN244 |
| E | LEU245 |
| E | GLY246 |
| E | GLY247 |
| E | HIS249 |
| E | LYS289 |
| E | THR340 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue CIT F 700 |
| Chain | Residue |
| F | HIS234 |
| F | GLN244 |
| F | LEU245 |
| F | GLY246 |
| F | GLY247 |
| F | HIS249 |
| F | LYS289 |
| F | THR340 |
| F | TYR342 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | Domain: {"description":"Nsp15 N-terminal oligomerization","evidences":[{"source":"PROSITE-ProRule","id":"PRU01305","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 750 |
| Details | Domain: {"description":"AV-Nsp11N/CoV-Nsp15M","evidences":[{"source":"PROSITE-ProRule","id":"PRU01306","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 834 |
| Details | Domain: {"description":"NendoU","evidences":[{"source":"PROSITE-ProRule","id":"PRU01303","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor; for uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Site: {"description":"Uracil recognition site","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
