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7KDV

Murine core lysosomal multienzyme complex (LMC) composed of acid beta-galactosidase (GLB1) and protective protein cathepsin A (PPCA, CTSA)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
A0004565molecular_functionbeta-galactosidase activity
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005773cellular_componentvacuole
A0005794cellular_componentGolgi apparatus
A0005975biological_processcarbohydrate metabolic process
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016936molecular_functiongalactoside binding
A0019388biological_processgalactose catabolic process
A0042803molecular_functionprotein homodimerization activity
A0043231cellular_componentintracellular membrane-bounded organelle
A0051413biological_processresponse to cortisone
A1904016biological_processresponse to Thyroglobulin triiodothyronine
B0004180molecular_functioncarboxypeptidase activity
B0004185molecular_functionserine-type carboxypeptidase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0006508biological_processproteolysis
B0031647biological_processregulation of protein stability
B1904715biological_processnegative regulation of chaperone-mediated autophagy
C0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
C0004565molecular_functionbeta-galactosidase activity
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005773cellular_componentvacuole
C0005794cellular_componentGolgi apparatus
C0005975biological_processcarbohydrate metabolic process
C0016787molecular_functionhydrolase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0016936molecular_functiongalactoside binding
C0019388biological_processgalactose catabolic process
C0042803molecular_functionprotein homodimerization activity
C0043231cellular_componentintracellular membrane-bounded organelle
C0051413biological_processresponse to cortisone
C1904016biological_processresponse to Thyroglobulin triiodothyronine
D0004180molecular_functioncarboxypeptidase activity
D0004185molecular_functionserine-type carboxypeptidase activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0006508biological_processproteolysis
D0031647biological_processregulation of protein stability
D1904715biological_processnegative regulation of chaperone-mediated autophagy
E0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
E0004565molecular_functionbeta-galactosidase activity
E0005615cellular_componentextracellular space
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005773cellular_componentvacuole
E0005794cellular_componentGolgi apparatus
E0005975biological_processcarbohydrate metabolic process
E0016787molecular_functionhydrolase activity
E0016798molecular_functionhydrolase activity, acting on glycosyl bonds
E0016936molecular_functiongalactoside binding
E0019388biological_processgalactose catabolic process
E0042803molecular_functionprotein homodimerization activity
E0043231cellular_componentintracellular membrane-bounded organelle
E0051413biological_processresponse to cortisone
E1904016biological_processresponse to Thyroglobulin triiodothyronine
F0004180molecular_functioncarboxypeptidase activity
F0004185molecular_functionserine-type carboxypeptidase activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005764cellular_componentlysosome
F0006508biological_processproteolysis
F0031647biological_processregulation of protein stability
F1904715biological_processnegative regulation of chaperone-mediated autophagy
G0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
G0004565molecular_functionbeta-galactosidase activity
G0005615cellular_componentextracellular space
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005773cellular_componentvacuole
G0005794cellular_componentGolgi apparatus
G0005975biological_processcarbohydrate metabolic process
G0016787molecular_functionhydrolase activity
G0016798molecular_functionhydrolase activity, acting on glycosyl bonds
G0016936molecular_functiongalactoside binding
G0019388biological_processgalactose catabolic process
G0042803molecular_functionprotein homodimerization activity
G0043231cellular_componentintracellular membrane-bounded organelle
G0051413biological_processresponse to cortisone
G1904016biological_processresponse to Thyroglobulin triiodothyronine
H0004180molecular_functioncarboxypeptidase activity
H0004185molecular_functionserine-type carboxypeptidase activity
H0005515molecular_functionprotein binding
H0005739cellular_componentmitochondrion
H0005764cellular_componentlysosome
H0006508biological_processproteolysis
H0031647biological_processregulation of protein stability
H1904715biological_processnegative regulation of chaperone-mediated autophagy
I0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
I0004565molecular_functionbeta-galactosidase activity
I0005615cellular_componentextracellular space
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005773cellular_componentvacuole
I0005794cellular_componentGolgi apparatus
I0005975biological_processcarbohydrate metabolic process
I0016787molecular_functionhydrolase activity
I0016798molecular_functionhydrolase activity, acting on glycosyl bonds
I0016936molecular_functiongalactoside binding
I0019388biological_processgalactose catabolic process
I0042803molecular_functionprotein homodimerization activity
I0043231cellular_componentintracellular membrane-bounded organelle
I0051413biological_processresponse to cortisone
I1904016biological_processresponse to Thyroglobulin triiodothyronine
J0004180molecular_functioncarboxypeptidase activity
J0004185molecular_functionserine-type carboxypeptidase activity
J0005515molecular_functionprotein binding
J0005739cellular_componentmitochondrion
J0005764cellular_componentlysosome
J0006508biological_processproteolysis
J0031647biological_processregulation of protein stability
J1904715biological_processnegative regulation of chaperone-mediated autophagy
K0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
K0004565molecular_functionbeta-galactosidase activity
K0005615cellular_componentextracellular space
K0005737cellular_componentcytoplasm
K0005764cellular_componentlysosome
K0005773cellular_componentvacuole
K0005794cellular_componentGolgi apparatus
K0005975biological_processcarbohydrate metabolic process
K0016787molecular_functionhydrolase activity
K0016798molecular_functionhydrolase activity, acting on glycosyl bonds
K0016936molecular_functiongalactoside binding
K0019388biological_processgalactose catabolic process
K0042803molecular_functionprotein homodimerization activity
K0043231cellular_componentintracellular membrane-bounded organelle
K0051413biological_processresponse to cortisone
K1904016biological_processresponse to Thyroglobulin triiodothyronine
L0004180molecular_functioncarboxypeptidase activity
L0004185molecular_functionserine-type carboxypeptidase activity
L0005515molecular_functionprotein binding
L0005739cellular_componentmitochondrion
L0005764cellular_componentlysosome
L0006508biological_processproteolysis
L0031647biological_processregulation of protein stability
L1904715biological_processnegative regulation of chaperone-mediated autophagy
Functional Information from PROSITE/UniProt
site_idPS00131
Number of Residues8
DetailsCARBOXYPEPT_SER_SER Serine carboxypeptidases, serine active site. LtGESYAG
ChainResidueDetails
BLEU169-GLY176

site_idPS00560
Number of Residues18
DetailsCARBOXYPEPT_SER_HIS Serine carboxypeptidases, histidine active site. ItfLtIkGAGHmVPtdkP
ChainResidueDetails
BILE441-PRO458

site_idPS01182
Number of Residues13
DetailsGLYCOSYL_HYDROL_F35 Glycosyl hydrolases family 35 putative active site. GGPIItvQvENEY
ChainResidueDetails
AGLY178-TYR190

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
BSER173
HSER173
HASP394
HHIS451
JSER173
JASP394
JHIS451
LSER173
LASP394
LHIS451
BASP394
BHIS451
DSER173
DASP394
DHIS451
FSER173
FASP394
FHIS451

site_idSWS_FT_FI2
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:16170054
ChainResidueDetails
BASN140
JASN327
LASN140
LASN327
BASN327
DASN140
DASN327
FASN140
FASN327
HASN140
HASN327
JASN140

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P16278
ChainResidueDetails
ATYR84
EGLU130
EASN188
ETYR334
GTYR84
GGLU130
GASN188
GTYR334
ITYR84
IGLU130
IASN188
AGLU130
ITYR334
KTYR84
KGLU130
KASN188
KTYR334
AASN188
ATYR334
CTYR84
CGLU130
CASN188
CTYR334
ETYR84

site_idSWS_FT_FI4
Number of Residues42
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN248
CASN504
CASN510
CASN544
CASN557
CASN617
EASN248
EASN500
EASN504
EASN510
EASN544
AASN500
EASN557
EASN617
GASN248
GASN500
GASN504
GASN510
GASN544
GASN557
GASN617
IASN248
AASN504
IASN500
IASN504
IASN510
IASN544
IASN557
IASN617
KASN248
KASN500
KASN504
KASN510
AASN510
KASN544
KASN557
KASN617
AASN544
AASN557
AASN617
CASN248
CASN500

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PDB entries from 2024-07-24

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