7KC0

Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005657	cellular_component	replication fork
A	0005829	cellular_component	cytosol
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006278	biological_process	RNA-templated DNA biosynthetic process
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006297	biological_process	nucleotide-excision repair, DNA gap filling
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0008270	molecular_function	zinc ion binding
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0034061	molecular_function	DNA polymerase activity
A	0043137	biological_process	DNA replication, removal of RNA primer
A	0043625	cellular_component	delta DNA polymerase complex
A	0045004	biological_process	DNA replication proofreading
A	0045005	biological_process	DNA-templated DNA replication maintenance of fidelity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0060090	molecular_function	molecular adaptor activity
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006259	biological_process	DNA metabolic process
B	0006260	biological_process	DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006272	biological_process	leading strand elongation
B	0006273	biological_process	lagging strand elongation
B	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006301	biological_process	DNA damage tolerance
B	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
B	0016035	cellular_component	zeta DNA polymerase complex
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034061	molecular_function	DNA polymerase activity
B	0042276	biological_process	error-prone translesion synthesis
B	0043137	biological_process	DNA replication, removal of RNA primer
B	0043625	cellular_component	delta DNA polymerase complex
B	0071897	biological_process	DNA biosynthetic process
C	0000510	molecular_function	H3-H4 histone complex chaperone activity
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0006259	biological_process	DNA metabolic process
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006273	biological_process	lagging strand elongation
C	0006277	biological_process	DNA amplification
C	0006278	biological_process	RNA-templated DNA biosynthetic process
C	0006284	biological_process	base-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
C	0016035	cellular_component	zeta DNA polymerase complex
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0042276	biological_process	error-prone translesion synthesis
C	0043137	biological_process	DNA replication, removal of RNA primer
C	0043625	cellular_component	delta DNA polymerase complex
E	0000278	biological_process	mitotic cell cycle
E	0000710	biological_process	meiotic mismatch repair
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005657	cellular_component	replication fork
E	0006260	biological_process	DNA replication
E	0006272	biological_process	leading strand elongation
E	0006273	biological_process	lagging strand elongation
E	0006275	biological_process	regulation of DNA replication
E	0006289	biological_process	nucleotide-excision repair
E	0006298	biological_process	mismatch repair
E	0006301	biological_process	DNA damage tolerance
E	0006974	biological_process	DNA damage response
E	0007064	biological_process	mitotic sister chromatid cohesion
E	0019985	biological_process	translesion synthesis
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0030466	biological_process	silent mating-type cassette heterochromatin formation
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0034087	biological_process	establishment of mitotic sister chromatid cohesion
E	0035753	biological_process	maintenance of DNA trinucleotide repeats
E	0042802	molecular_function	identical protein binding
E	0043626	cellular_component	PCNA complex
E	0045739	biological_process	positive regulation of DNA repair
E	0045740	biological_process	positive regulation of DNA replication
E	0051054	biological_process	positive regulation of DNA metabolic process
E	0070987	biological_process	error-free translesion synthesis
F	0000278	biological_process	mitotic cell cycle
F	0000710	biological_process	meiotic mismatch repair
F	0000781	cellular_component	chromosome, telomeric region
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005657	cellular_component	replication fork
F	0006260	biological_process	DNA replication
F	0006272	biological_process	leading strand elongation
F	0006273	biological_process	lagging strand elongation
F	0006275	biological_process	regulation of DNA replication
F	0006289	biological_process	nucleotide-excision repair
F	0006298	biological_process	mismatch repair
F	0006301	biological_process	DNA damage tolerance
F	0006974	biological_process	DNA damage response
F	0007064	biological_process	mitotic sister chromatid cohesion
F	0019985	biological_process	translesion synthesis
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0030466	biological_process	silent mating-type cassette heterochromatin formation
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0034087	biological_process	establishment of mitotic sister chromatid cohesion
F	0035753	biological_process	maintenance of DNA trinucleotide repeats
F	0042802	molecular_function	identical protein binding
F	0043626	cellular_component	PCNA complex
F	0045739	biological_process	positive regulation of DNA repair
F	0045740	biological_process	positive regulation of DNA replication
F	0051054	biological_process	positive regulation of DNA metabolic process
F	0070987	biological_process	error-free translesion synthesis
G	0000278	biological_process	mitotic cell cycle
G	0000710	biological_process	meiotic mismatch repair
G	0000781	cellular_component	chromosome, telomeric region
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005657	cellular_component	replication fork
G	0006260	biological_process	DNA replication
G	0006272	biological_process	leading strand elongation
G	0006273	biological_process	lagging strand elongation
G	0006275	biological_process	regulation of DNA replication
G	0006289	biological_process	nucleotide-excision repair
G	0006298	biological_process	mismatch repair
G	0006301	biological_process	DNA damage tolerance
G	0006974	biological_process	DNA damage response
G	0007064	biological_process	mitotic sister chromatid cohesion
G	0019985	biological_process	translesion synthesis
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0030466	biological_process	silent mating-type cassette heterochromatin formation
G	0031509	biological_process	subtelomeric heterochromatin formation
G	0034087	biological_process	establishment of mitotic sister chromatid cohesion
G	0035753	biological_process	maintenance of DNA trinucleotide repeats
G	0042802	molecular_function	identical protein binding
G	0043626	cellular_component	PCNA complex
G	0045739	biological_process	positive regulation of DNA repair
G	0045740	biological_process	positive regulation of DNA replication
G	0051054	biological_process	positive regulation of DNA metabolic process
G	0070987	biological_process	error-free translesion synthesis

Functional Information from PROSITE/UniProt

site_id	PS00116
Number of Residues	9
Details	DNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSVMV

Chain	Residue	Details
A	TYR760-VAL768

---

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDHpvtLgmdLtSLsKIL

Chain	Residue	Details
F	ARG61-LEU79

---

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GIiAqAVDdSRVlLVsLeIgveaF

Chain	Residue	Details
F	GLY34-PHE57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"15166219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"12226657","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Zinc finger: {"description":"CysA-type","evidences":[{"source":"PubMed","id":"22119860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Motif: {"description":"CysB motif","evidences":[{"source":"PubMed","id":"22119860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22119860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---