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7K6C

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004146molecular_functiondihydrofolate reductase activity
A0005829cellular_componentcytosol
A0006730biological_processone-carbon metabolic process
A0016491molecular_functionoxidoreductase activity
A0044281biological_processsmall molecule metabolic process
A0046452biological_processdihydrofolate metabolic process
A0046654biological_processtetrahydrofolate biosynthetic process
A0046655biological_processfolic acid metabolic process
A0046872molecular_functionmetal ion binding
A0050661molecular_functionNADP binding
A0070401molecular_functionNADP+ binding
B0000166molecular_functionnucleotide binding
B0004146molecular_functiondihydrofolate reductase activity
B0005829cellular_componentcytosol
B0006730biological_processone-carbon metabolic process
B0016491molecular_functionoxidoreductase activity
B0044281biological_processsmall molecule metabolic process
B0046452biological_processdihydrofolate metabolic process
B0046654biological_processtetrahydrofolate biosynthetic process
B0046655biological_processfolic acid metabolic process
B0046872molecular_functionmetal ion binding
B0050661molecular_functionNADP binding
B0070401molecular_functionNADP+ binding
C0000166molecular_functionnucleotide binding
C0004146molecular_functiondihydrofolate reductase activity
C0005829cellular_componentcytosol
C0006730biological_processone-carbon metabolic process
C0016491molecular_functionoxidoreductase activity
C0044281biological_processsmall molecule metabolic process
C0046452biological_processdihydrofolate metabolic process
C0046654biological_processtetrahydrofolate biosynthetic process
C0046655biological_processfolic acid metabolic process
C0046872molecular_functionmetal ion binding
C0050661molecular_functionNADP binding
C0070401molecular_functionNADP+ binding
D0000166molecular_functionnucleotide binding
D0004146molecular_functiondihydrofolate reductase activity
D0005829cellular_componentcytosol
D0006730biological_processone-carbon metabolic process
D0016491molecular_functionoxidoreductase activity
D0044281biological_processsmall molecule metabolic process
D0046452biological_processdihydrofolate metabolic process
D0046654biological_processtetrahydrofolate biosynthetic process
D0046655biological_processfolic acid metabolic process
D0046872molecular_functionmetal ion binding
D0050661molecular_functionNADP binding
D0070401molecular_functionNADP+ binding
E0000166molecular_functionnucleotide binding
E0004146molecular_functiondihydrofolate reductase activity
E0005829cellular_componentcytosol
E0006730biological_processone-carbon metabolic process
E0016491molecular_functionoxidoreductase activity
E0044281biological_processsmall molecule metabolic process
E0046452biological_processdihydrofolate metabolic process
E0046654biological_processtetrahydrofolate biosynthetic process
E0046655biological_processfolic acid metabolic process
E0046872molecular_functionmetal ion binding
E0050661molecular_functionNADP binding
E0070401molecular_functionNADP+ binding
F0000166molecular_functionnucleotide binding
F0004146molecular_functiondihydrofolate reductase activity
F0005829cellular_componentcytosol
F0006730biological_processone-carbon metabolic process
F0016491molecular_functionoxidoreductase activity
F0044281biological_processsmall molecule metabolic process
F0046452biological_processdihydrofolate metabolic process
F0046654biological_processtetrahydrofolate biosynthetic process
F0046655biological_processfolic acid metabolic process
F0046872molecular_functionmetal ion binding
F0050661molecular_functionNADP binding
F0070401molecular_functionNADP+ binding
G0000166molecular_functionnucleotide binding
G0004146molecular_functiondihydrofolate reductase activity
G0005829cellular_componentcytosol
G0006730biological_processone-carbon metabolic process
G0016491molecular_functionoxidoreductase activity
G0044281biological_processsmall molecule metabolic process
G0046452biological_processdihydrofolate metabolic process
G0046654biological_processtetrahydrofolate biosynthetic process
G0046655biological_processfolic acid metabolic process
G0046872molecular_functionmetal ion binding
G0050661molecular_functionNADP binding
G0070401molecular_functionNADP+ binding
Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues23
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGadgaIPWrlpe.DqarFkriT
ChainResidueDetails
AVAL16-THR38

239803

PDB entries from 2025-08-06

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