7K6C

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004146	molecular_function	dihydrofolate reductase activity
A	0005829	cellular_component	cytosol
A	0006730	biological_process	one-carbon metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0044281	biological_process	small molecule metabolic process
A	0046452	biological_process	dihydrofolate metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046655	biological_process	folic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0070401	molecular_function	NADP+ binding
B	0000166	molecular_function	nucleotide binding
B	0004146	molecular_function	dihydrofolate reductase activity
B	0005829	cellular_component	cytosol
B	0006730	biological_process	one-carbon metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0044281	biological_process	small molecule metabolic process
B	0046452	biological_process	dihydrofolate metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046655	biological_process	folic acid metabolic process
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
B	0070401	molecular_function	NADP+ binding
C	0000166	molecular_function	nucleotide binding
C	0004146	molecular_function	dihydrofolate reductase activity
C	0005829	cellular_component	cytosol
C	0006730	biological_process	one-carbon metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0044281	biological_process	small molecule metabolic process
C	0046452	biological_process	dihydrofolate metabolic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046655	biological_process	folic acid metabolic process
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
C	0070401	molecular_function	NADP+ binding
D	0000166	molecular_function	nucleotide binding
D	0004146	molecular_function	dihydrofolate reductase activity
D	0005829	cellular_component	cytosol
D	0006730	biological_process	one-carbon metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0044281	biological_process	small molecule metabolic process
D	0046452	biological_process	dihydrofolate metabolic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046655	biological_process	folic acid metabolic process
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding
D	0070401	molecular_function	NADP+ binding
E	0000166	molecular_function	nucleotide binding
E	0004146	molecular_function	dihydrofolate reductase activity
E	0005829	cellular_component	cytosol
E	0006730	biological_process	one-carbon metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0044281	biological_process	small molecule metabolic process
E	0046452	biological_process	dihydrofolate metabolic process
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046655	biological_process	folic acid metabolic process
E	0046872	molecular_function	metal ion binding
E	0050661	molecular_function	NADP binding
E	0070401	molecular_function	NADP+ binding
F	0000166	molecular_function	nucleotide binding
F	0004146	molecular_function	dihydrofolate reductase activity
F	0005829	cellular_component	cytosol
F	0006730	biological_process	one-carbon metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0044281	biological_process	small molecule metabolic process
F	0046452	biological_process	dihydrofolate metabolic process
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046655	biological_process	folic acid metabolic process
F	0046872	molecular_function	metal ion binding
F	0050661	molecular_function	NADP binding
F	0070401	molecular_function	NADP+ binding
G	0000166	molecular_function	nucleotide binding
G	0004146	molecular_function	dihydrofolate reductase activity
G	0005829	cellular_component	cytosol
G	0006730	biological_process	one-carbon metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0044281	biological_process	small molecule metabolic process
G	0046452	biological_process	dihydrofolate metabolic process
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046655	biological_process	folic acid metabolic process
G	0046872	molecular_function	metal ion binding
G	0050661	molecular_function	NADP binding
G	0070401	molecular_function	NADP+ binding

Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGadgaIPWrlpe.DqarFkriT

Chain	Residue	Details
A	VAL16-THR38

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