Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7K4H

Human Arginase 1 in complex with compound 04.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0004053	molecular_function	arginase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006525	biological_process	arginine metabolic process
A	0006527	biological_process	L-arginine catabolic process
A	0006950	biological_process	response to stress
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0030145	molecular_function	manganese ion binding
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042127	biological_process	regulation of cell population proliferation
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042832	biological_process	defense response to protozoan
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0051707	biological_process	response to other organism
A	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
A	0070947	biological_process	neutrophil-mediated killing of fungus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0000050	biological_process	urea cycle
B	0004053	molecular_function	arginase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006525	biological_process	arginine metabolic process
B	0006527	biological_process	L-arginine catabolic process
B	0006950	biological_process	response to stress
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0030145	molecular_function	manganese ion binding
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042127	biological_process	regulation of cell population proliferation
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042832	biological_process	defense response to protozoan
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0051707	biological_process	response to other organism
B	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
B	0070947	biological_process	neutrophil-mediated killing of fungus
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0000050	biological_process	urea cycle
C	0004053	molecular_function	arginase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006525	biological_process	arginine metabolic process
C	0006527	biological_process	L-arginine catabolic process
C	0006950	biological_process	response to stress
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0030145	molecular_function	manganese ion binding
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042127	biological_process	regulation of cell population proliferation
C	0042130	biological_process	negative regulation of T cell proliferation
C	0042832	biological_process	defense response to protozoan
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0051707	biological_process	response to other organism
C	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
C	0070947	biological_process	neutrophil-mediated killing of fungus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
D	0000050	biological_process	urea cycle
D	0004053	molecular_function	arginase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006525	biological_process	arginine metabolic process
D	0006527	biological_process	L-arginine catabolic process
D	0006950	biological_process	response to stress
D	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
D	0030145	molecular_function	manganese ion binding
D	0035578	cellular_component	azurophil granule lumen
D	0035580	cellular_component	specific granule lumen
D	0042127	biological_process	regulation of cell population proliferation
D	0042130	biological_process	negative regulation of T cell proliferation
D	0042832	biological_process	defense response to protozoan
D	0046007	biological_process	negative regulation of activated T cell proliferation
D	0046872	molecular_function	metal ion binding
D	0051707	biological_process	response to other organism
D	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
D	0070947	biological_process	neutrophil-mediated killing of fungus
D	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
E	0000050	biological_process	urea cycle
E	0004053	molecular_function	arginase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006525	biological_process	arginine metabolic process
E	0006527	biological_process	L-arginine catabolic process
E	0006950	biological_process	response to stress
E	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
E	0030145	molecular_function	manganese ion binding
E	0035578	cellular_component	azurophil granule lumen
E	0035580	cellular_component	specific granule lumen
E	0042127	biological_process	regulation of cell population proliferation
E	0042130	biological_process	negative regulation of T cell proliferation
E	0042832	biological_process	defense response to protozoan
E	0046007	biological_process	negative regulation of activated T cell proliferation
E	0046872	molecular_function	metal ion binding
E	0051707	biological_process	response to other organism
E	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
E	0070947	biological_process	neutrophil-mediated killing of fungus
E	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
F	0000050	biological_process	urea cycle
F	0004053	molecular_function	arginase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006525	biological_process	arginine metabolic process
F	0006527	biological_process	L-arginine catabolic process
F	0006950	biological_process	response to stress
F	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
F	0030145	molecular_function	manganese ion binding
F	0035578	cellular_component	azurophil granule lumen
F	0035580	cellular_component	specific granule lumen
F	0042127	biological_process	regulation of cell population proliferation
F	0042130	biological_process	negative regulation of T cell proliferation
F	0042832	biological_process	defense response to protozoan
F	0046007	biological_process	negative regulation of activated T cell proliferation
F	0046872	molecular_function	metal ion binding
F	0051707	biological_process	response to other organism
F	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
F	0070947	biological_process	neutrophil-mediated killing of fungus
F	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDVDgldPsftPAtgtpvvgG

Chain	Residue	Details
A	SER230-GLY251

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16141327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17469833","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17562323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18802628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21728378","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2004","submissionDatabase":"PDB data bank","title":"Crystal structure of human arginase I: the mutant E256Q.","authors":["Di Costanzo L.","Guadalupe S.","Mora A.","Centeno F.","Christianson D.W."]}},{"source":"PDB","id":"1WVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SKK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21728378","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GN0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16141327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17562323","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1WVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PLL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)