7K3J

Crystal structure of dLC8 in complex with Panoramix TQT+TQ peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000132	biological_process	establishment of mitotic spindle orientation
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005814	cellular_component	centriole
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0007017	biological_process	microtubule-based process
A	0007283	biological_process	spermatogenesis
A	0007290	biological_process	spermatid nucleus elongation
A	0007291	biological_process	sperm individualization
A	0007476	biological_process	imaginal disc-derived wing morphogenesis
A	0008407	biological_process	chaeta morphogenesis
A	0015630	cellular_component	microtubule cytoskeleton
A	0022416	biological_process	chaeta development
A	0030286	cellular_component	dynein complex
A	0032991	cellular_component	protein-containing complex
A	0034454	biological_process	microtubule anchoring at centrosome
A	0035220	biological_process	wing disc development
A	0042803	molecular_function	protein homodimerization activity
A	0045505	molecular_function	dynein intermediate chain binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0048477	biological_process	oogenesis
A	0051017	biological_process	actin filament bundle assembly
A	0051959	molecular_function	dynein light intermediate chain binding
A	0090571	cellular_component	RNA polymerase II transcription repressor complex
A	0097718	molecular_function	disordered domain specific binding
A	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
A	1904801	biological_process	positive regulation of neuron remodeling
C	0000132	biological_process	establishment of mitotic spindle orientation
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005814	cellular_component	centriole
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0007017	biological_process	microtubule-based process
C	0007283	biological_process	spermatogenesis
C	0007290	biological_process	spermatid nucleus elongation
C	0007291	biological_process	sperm individualization
C	0007476	biological_process	imaginal disc-derived wing morphogenesis
C	0008407	biological_process	chaeta morphogenesis
C	0015630	cellular_component	microtubule cytoskeleton
C	0022416	biological_process	chaeta development
C	0030286	cellular_component	dynein complex
C	0032991	cellular_component	protein-containing complex
C	0034454	biological_process	microtubule anchoring at centrosome
C	0035220	biological_process	wing disc development
C	0042803	molecular_function	protein homodimerization activity
C	0045505	molecular_function	dynein intermediate chain binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0048477	biological_process	oogenesis
C	0051017	biological_process	actin filament bundle assembly
C	0051959	molecular_function	dynein light intermediate chain binding
C	0090571	cellular_component	RNA polymerase II transcription repressor complex
C	0097718	molecular_function	disordered domain specific binding
C	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
C	1904801	biological_process	positive regulation of neuron remodeling
E	0000132	biological_process	establishment of mitotic spindle orientation
E	0003714	molecular_function	transcription corepressor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005814	cellular_component	centriole
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0007017	biological_process	microtubule-based process
E	0007283	biological_process	spermatogenesis
E	0007290	biological_process	spermatid nucleus elongation
E	0007291	biological_process	sperm individualization
E	0007476	biological_process	imaginal disc-derived wing morphogenesis
E	0008407	biological_process	chaeta morphogenesis
E	0015630	cellular_component	microtubule cytoskeleton
E	0022416	biological_process	chaeta development
E	0030286	cellular_component	dynein complex
E	0032991	cellular_component	protein-containing complex
E	0034454	biological_process	microtubule anchoring at centrosome
E	0035220	biological_process	wing disc development
E	0042803	molecular_function	protein homodimerization activity
E	0045505	molecular_function	dynein intermediate chain binding
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0048477	biological_process	oogenesis
E	0051017	biological_process	actin filament bundle assembly
E	0051959	molecular_function	dynein light intermediate chain binding
E	0090571	cellular_component	RNA polymerase II transcription repressor complex
E	0097718	molecular_function	disordered domain specific binding
E	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
E	1904801	biological_process	positive regulation of neuron remodeling
G	0000132	biological_process	establishment of mitotic spindle orientation
G	0003714	molecular_function	transcription corepressor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005814	cellular_component	centriole
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005875	cellular_component	microtubule associated complex
G	0007017	biological_process	microtubule-based process
G	0007283	biological_process	spermatogenesis
G	0007290	biological_process	spermatid nucleus elongation
G	0007291	biological_process	sperm individualization
G	0007476	biological_process	imaginal disc-derived wing morphogenesis
G	0008407	biological_process	chaeta morphogenesis
G	0015630	cellular_component	microtubule cytoskeleton
G	0022416	biological_process	chaeta development
G	0030286	cellular_component	dynein complex
G	0032991	cellular_component	protein-containing complex
G	0034454	biological_process	microtubule anchoring at centrosome
G	0035220	biological_process	wing disc development
G	0042803	molecular_function	protein homodimerization activity
G	0045505	molecular_function	dynein intermediate chain binding
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0048477	biological_process	oogenesis
G	0051017	biological_process	actin filament bundle assembly
G	0051959	molecular_function	dynein light intermediate chain binding
G	0090571	cellular_component	RNA polymerase II transcription repressor complex
G	0097718	molecular_function	disordered domain specific binding
G	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
G	1904801	biological_process	positive regulation of neuron remodeling
I	0000132	biological_process	establishment of mitotic spindle orientation
I	0003714	molecular_function	transcription corepressor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005814	cellular_component	centriole
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0005875	cellular_component	microtubule associated complex
I	0007017	biological_process	microtubule-based process
I	0007283	biological_process	spermatogenesis
I	0007290	biological_process	spermatid nucleus elongation
I	0007291	biological_process	sperm individualization
I	0007476	biological_process	imaginal disc-derived wing morphogenesis
I	0008407	biological_process	chaeta morphogenesis
I	0015630	cellular_component	microtubule cytoskeleton
I	0022416	biological_process	chaeta development
I	0030286	cellular_component	dynein complex
I	0032991	cellular_component	protein-containing complex
I	0034454	biological_process	microtubule anchoring at centrosome
I	0035220	biological_process	wing disc development
I	0042803	molecular_function	protein homodimerization activity
I	0045505	molecular_function	dynein intermediate chain binding
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0048477	biological_process	oogenesis
I	0051017	biological_process	actin filament bundle assembly
I	0051959	molecular_function	dynein light intermediate chain binding
I	0090571	cellular_component	RNA polymerase II transcription repressor complex
I	0097718	molecular_function	disordered domain specific binding
I	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
I	1904801	biological_process	positive regulation of neuron remodeling
K	0000132	biological_process	establishment of mitotic spindle orientation
K	0003714	molecular_function	transcription corepressor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005814	cellular_component	centriole
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0005875	cellular_component	microtubule associated complex
K	0007017	biological_process	microtubule-based process
K	0007283	biological_process	spermatogenesis
K	0007290	biological_process	spermatid nucleus elongation
K	0007291	biological_process	sperm individualization
K	0007476	biological_process	imaginal disc-derived wing morphogenesis
K	0008407	biological_process	chaeta morphogenesis
K	0015630	cellular_component	microtubule cytoskeleton
K	0022416	biological_process	chaeta development
K	0030286	cellular_component	dynein complex
K	0032991	cellular_component	protein-containing complex
K	0034454	biological_process	microtubule anchoring at centrosome
K	0035220	biological_process	wing disc development
K	0042803	molecular_function	protein homodimerization activity
K	0045505	molecular_function	dynein intermediate chain binding
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0048477	biological_process	oogenesis
K	0051017	biological_process	actin filament bundle assembly
K	0051959	molecular_function	dynein light intermediate chain binding
K	0090571	cellular_component	RNA polymerase II transcription repressor complex
K	0097718	molecular_function	disordered domain specific binding
K	0141006	biological_process	piRNA-mediated retrotransposon silencing by heterochromatin formation
K	1904801	biological_process	positive regulation of neuron remodeling

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 A 101

Chain	Residue
A	GLU15
A	ARG71

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site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 C 101

Chain	Residue
C	MET13
C	SER14
C	GLU15
C	ARG71
G	LYS9

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site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 I 101

Chain	Residue
I	ARG71
I	SER14
I	GLU15

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Functional Information from PROSITE/UniProt

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
A	HIS55-GLU69

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