Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7K0O

Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004758	molecular_function	serine C-palmitoyltransferase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006665	biological_process	sphingolipid metabolic process
A	0006686	biological_process	sphingomyelin biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0017059	cellular_component	serine palmitoyltransferase complex
A	0030148	biological_process	sphingolipid biosynthetic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0043604	biological_process	amide biosynthetic process
A	0046511	biological_process	sphinganine biosynthetic process
A	0046512	biological_process	sphingosine biosynthetic process
A	0046513	biological_process	ceramide biosynthetic process
A	1904504	biological_process	positive regulation of lipophagy
A	1904649	biological_process	regulation of fat cell apoptotic process
B	0004758	molecular_function	serine C-palmitoyltransferase activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006665	biological_process	sphingolipid metabolic process
B	0006686	biological_process	sphingomyelin biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0017059	cellular_component	serine palmitoyltransferase complex
B	0030148	biological_process	sphingolipid biosynthetic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0046511	biological_process	sphinganine biosynthetic process
B	0046512	biological_process	sphingosine biosynthetic process
B	0046513	biological_process	ceramide biosynthetic process
B	0060612	biological_process	adipose tissue development
B	1904504	biological_process	positive regulation of lipophagy
C	0004758	molecular_function	serine C-palmitoyltransferase activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006665	biological_process	sphingolipid metabolic process
C	0008104	biological_process	protein localization
C	0016020	cellular_component	membrane
C	0017059	cellular_component	serine palmitoyltransferase complex
C	0030148	biological_process	sphingolipid biosynthetic process
C	0046512	biological_process	sphingosine biosynthetic process
C	0046513	biological_process	ceramide biosynthetic process
D	0002903	biological_process	negative regulation of B cell apoptotic process
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006665	biological_process	sphingolipid metabolic process
D	0006672	biological_process	ceramide metabolic process
D	0006686	biological_process	sphingomyelin biosynthetic process
D	0006940	biological_process	regulation of smooth muscle contraction
D	0010508	biological_process	positive regulation of autophagy
D	0016020	cellular_component	membrane
D	0017059	cellular_component	serine palmitoyltransferase complex
D	0030148	biological_process	sphingolipid biosynthetic process
D	0030667	cellular_component	secretory granule membrane
D	0035579	cellular_component	specific granule membrane
D	0042552	biological_process	myelination
D	0061744	biological_process	motor behavior
D	0090153	biological_process	regulation of sphingolipid biosynthetic process
D	0090156	biological_process	intracellular sphingolipid homeostasis
D	1900060	biological_process	negative regulation of ceramide biosynthetic process
D	1900182	biological_process	positive regulation of protein localization to nucleus
D	2000303	biological_process	regulation of ceramide biosynthetic process
E	0004758	molecular_function	serine C-palmitoyltransferase activity
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006629	biological_process	lipid metabolic process
E	0006665	biological_process	sphingolipid metabolic process
E	0006686	biological_process	sphingomyelin biosynthetic process
E	0009058	biological_process	biosynthetic process
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0017059	cellular_component	serine palmitoyltransferase complex
E	0030148	biological_process	sphingolipid biosynthetic process
E	0030170	molecular_function	pyridoxal phosphate binding
E	0043604	biological_process	amide biosynthetic process
E	0046511	biological_process	sphinganine biosynthetic process
E	0046512	biological_process	sphingosine biosynthetic process
E	0046513	biological_process	ceramide biosynthetic process
E	1904504	biological_process	positive regulation of lipophagy
E	1904649	biological_process	regulation of fat cell apoptotic process
F	0004758	molecular_function	serine C-palmitoyltransferase activity
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006629	biological_process	lipid metabolic process
F	0006665	biological_process	sphingolipid metabolic process
F	0006686	biological_process	sphingomyelin biosynthetic process
F	0009058	biological_process	biosynthetic process
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0017059	cellular_component	serine palmitoyltransferase complex
F	0030148	biological_process	sphingolipid biosynthetic process
F	0030170	molecular_function	pyridoxal phosphate binding
F	0046511	biological_process	sphinganine biosynthetic process
F	0046512	biological_process	sphingosine biosynthetic process
F	0046513	biological_process	ceramide biosynthetic process
F	0060612	biological_process	adipose tissue development
F	1904504	biological_process	positive regulation of lipophagy
G	0004758	molecular_function	serine C-palmitoyltransferase activity
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006629	biological_process	lipid metabolic process
G	0006665	biological_process	sphingolipid metabolic process
G	0008104	biological_process	protein localization
G	0016020	cellular_component	membrane
G	0017059	cellular_component	serine palmitoyltransferase complex
G	0030148	biological_process	sphingolipid biosynthetic process
G	0046512	biological_process	sphingosine biosynthetic process
G	0046513	biological_process	ceramide biosynthetic process
H	0002903	biological_process	negative regulation of B cell apoptotic process
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005886	cellular_component	plasma membrane
H	0006665	biological_process	sphingolipid metabolic process
H	0006672	biological_process	ceramide metabolic process
H	0006686	biological_process	sphingomyelin biosynthetic process
H	0006940	biological_process	regulation of smooth muscle contraction
H	0010508	biological_process	positive regulation of autophagy
H	0016020	cellular_component	membrane
H	0017059	cellular_component	serine palmitoyltransferase complex
H	0030148	biological_process	sphingolipid biosynthetic process
H	0030667	cellular_component	secretory granule membrane
H	0035579	cellular_component	specific granule membrane
H	0042552	biological_process	myelination
H	0061744	biological_process	motor behavior
H	0090153	biological_process	regulation of sphingolipid biosynthetic process
H	0090156	biological_process	intracellular sphingolipid homeostasis
H	1900060	biological_process	negative regulation of ceramide biosynthetic process
H	1900182	biological_process	positive regulation of protein localization to nucleus
H	2000303	biological_process	regulation of ceramide biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TFTKSFGASG

Chain	Residue	Details
B	THR376-GLY385

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1010
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL","evidences":[{"source":"PubMed","id":"23629659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	14
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Within the serine palmitoyltransferase (SPT) complex, defines the length of the acyl chain-binding pocket, determining the acyl-CoA substrate preference"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	146
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"33558762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6M4N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6M4O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CQI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CQK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	32
Details	Region: {"description":"Important for ceramide level-sensing","evidences":[{"source":"PubMed","id":"37308477","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Hydroxyproline","evidences":[{"source":"PubMed","id":"36408842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)