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7JVX

Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to peptide pSDpTpTDpSDPENEPFDED)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001933biological_processnegative regulation of protein phosphorylation
A0004438molecular_functionphosphatidylinositol-3-phosphate phosphatase activity
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0004726molecular_functionnon-membrane spanning protein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0006470biological_processprotein dephosphorylation
A0006629biological_processlipid metabolic process
A0006661biological_processphosphatidylinositol biosynthetic process
A0006915biological_processapoptotic process
A0007056biological_processspindle assembly involved in female meiosis
A0007270biological_processneuron-neuron synaptic transmission
A0007399biological_processnervous system development
A0007416biological_processsynapse assembly
A0007417biological_processcentral nervous system development
A0007507biological_processheart development
A0007611biological_processlearning or memory
A0007626biological_processlocomotory behavior
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010719biological_processnegative regulation of epithelial to mesenchymal transition
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0010997molecular_functionanaphase-promoting complex binding
A0014069cellular_componentpostsynaptic density
A0016311biological_processdephosphorylation
A0016314molecular_functionphosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
A0016324cellular_componentapical plasma membrane
A0016477biological_processcell migration
A0016605cellular_componentPML body
A0016791molecular_functionphosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0019899molecular_functionenzyme binding
A0021542biological_processdentate gyrus development
A0021955biological_processcentral nervous system neuron axonogenesis
A0030165molecular_functionPDZ domain binding
A0030336biological_processnegative regulation of cell migration
A0030351molecular_functioninositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
A0030534biological_processadult behavior
A0030946molecular_functionprotein tyrosine phosphatase activity, metal-dependent
A0031647biological_processregulation of protein stability
A0032286biological_processcentral nervous system myelin maintenance
A0033137biological_processnegative regulation of peptidyl-serine phosphorylation
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0033555biological_processmulticellular organismal response to stress
A0035176biological_processsocial behavior
A0035749cellular_componentmyelin sheath adaxonal region
A0042711biological_processmaternal behavior
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043197cellular_componentdendritic spine
A0043220cellular_componentSchmidt-Lanterman incisure
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0045202cellular_componentsynapse
A0045475biological_processlocomotor rhythm
A0045668biological_processnegative regulation of osteoblast differentiation
A0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
A0045792biological_processnegative regulation of cell size
A0046621biological_processnegative regulation of organ growth
A0046856biological_processphosphatidylinositol dephosphorylation
A0048853biological_processforebrain morphogenesis
A0048870biological_processcell motility
A0050771biological_processnegative regulation of axonogenesis
A0050821biological_processprotein stabilization
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0051548biological_processnegative regulation of keratinocyte migration
A0051717molecular_functioninositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
A0051800molecular_functionphosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
A0051895biological_processnegative regulation of focal adhesion assembly
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0052866molecular_functionphosphatidylinositol phosphate phosphatase activity
A0060024biological_processrhythmic synaptic transmission
A0060070biological_processcanonical Wnt signaling pathway
A0060074biological_processsynapse maturation
A0060134biological_processprepulse inhibition
A0060997biological_processdendritic spine morphogenesis
A0071257biological_processcellular response to electrical stimulus
A0090394biological_processnegative regulation of excitatory postsynaptic potential
A0097105biological_processpresynaptic membrane assembly
A0097107biological_processpostsynaptic density assembly
A0140791molecular_functionhistone H2AXS140 phosphatase activity
A0140793molecular_functionhistone H2AXY142 phosphatase activity
A0180004molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
A0180005molecular_functionRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
A0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
A0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
A1902807biological_processnegative regulation of cell cycle G1/S phase transition
A1903690biological_processnegative regulation of wound healing, spreading of epidermal cells
A1904668biological_processpositive regulation of ubiquitin protein ligase activity
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1990381molecular_functionubiquitin-specific protease binding
A1990439molecular_functionMAP kinase serine/threonine phosphatase activity
A1990757molecular_functionubiquitin ligase activator activity
A2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
A2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
A2000463biological_processpositive regulation of excitatory postsynaptic potential
A2000773biological_processnegative regulation of cellular senescence
A2000808biological_processnegative regulation of synaptic vesicle clustering
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue PO4 A 501
ChainResidue
AGLU73
AARG74

site_idAC2
Number of Residues2
Detailsbinding site for residue PO4 A 502
ChainResidue
AGLU73
AHIS75

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCkaGkgRTG
ChainResidueDetails
AILE122-GLY132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00590
ChainResidueDetails
ACYS124

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:22814378
ChainResidueDetails
ATHR2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08586
ChainResidueDetails
ASER294

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:26166433
ChainResidueDetails
ATHR319
ATHR321

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by FRK => ECO:0000269|PubMed:19345329
ChainResidueDetails
ATYR336

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by GSK3-beta and PLK3 => ECO:0000269|PubMed:12297295, ECO:0000269|PubMed:20940307, ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR366

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK2 and PLK3 => ECO:0000269|PubMed:11035045, ECO:0000269|PubMed:12297295, ECO:0000269|PubMed:20940307
ChainResidueDetails
ASER370

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ROCK1 and CK2 => ECO:0000269|PubMed:11035045
ChainResidueDetails
ASER380

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by ROCK1 and CK2 => ECO:0000269|PubMed:11035045
ChainResidueDetails
ATHR401
ATHR402

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:11035045, ECO:0000269|PubMed:12297295
ChainResidueDetails
ASER404

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:10646847
ChainResidueDetails
ATHR420

site_idSWS_FT_FI12
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18716620
ChainResidueDetails
ALYS13
ALYS289

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 456
ChainResidueDetails
AASP92proton shuttle (general acid/base)
ACYS124covalent catalysis
AARG130transition state stabiliser

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PDB entries from 2024-11-06

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