7JV7

Crystal Structure of the yeast RNA Pol II CTD kinase CTDK-1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005829	cellular_component	cytosol
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006397	biological_process	mRNA processing
B	0006974	biological_process	DNA damage response
B	0008024	cellular_component	cyclin/CDK positive transcription elongation factor complex
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0031124	biological_process	mRNA 3'-end processing
B	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
B	0032806	cellular_component	carboxy-terminal domain protein kinase complex
B	0045903	biological_process	positive regulation of translational fidelity
B	0045943	biological_process	positive regulation of transcription by RNA polymerase I
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
B	0070692	cellular_component	CTDK-1 complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006397	biological_process	mRNA processing
C	0006974	biological_process	DNA damage response
C	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
C	0031124	biological_process	mRNA 3'-end processing
C	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
C	0032806	cellular_component	carboxy-terminal domain protein kinase complex
C	0045903	biological_process	positive regulation of translational fidelity
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0070692	cellular_component	CTDK-1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue FLC A 601

Chain	Residue
A	ARG305
C	LYS242
A	ARG329
A	TYR337
A	THR338
A	HOH721
A	HOH723
A	HOH810
C	HIS238
C	LYS239

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGEGTYGKVYkAkntntekl..........VALK

Chain	Residue	Details
A	VAL189-LYS212

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDVKgsNILI

Chain	Residue	Details
A	ILE302-ILE314

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
C	THR35

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	VAL189
A	LYS212

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15870265

Chain	Residue	Details
A	THR338

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