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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7JSN

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
A0042622cellular_componentphotoreceptor outer segment membrane
A0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
A0060041biological_processretina development in camera-type eye
A0097381cellular_componentphotoreceptor disc membrane
A0141162biological_processnegative regulation of cAMP/PKA signal transduction
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
B0005515molecular_functionprotein binding
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
B0016020cellular_componentmembrane
B0042622cellular_componentphotoreceptor outer segment membrane
B0043153biological_processentrainment of circadian clock by photoperiod
B0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
B0060041biological_processretina development in camera-type eye
B0097381cellular_componentphotoreceptor disc membrane
B0141162biological_processnegative regulation of cAMP/PKA signal transduction
C0001750cellular_componentphotoreceptor outer segment
C0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
C0004857molecular_functionenzyme inhibitor activity
C0005515molecular_functionprotein binding
C0007601biological_processvisual perception
C0008270molecular_functionzinc ion binding
C0030553molecular_functioncGMP binding
C0042622cellular_componentphotoreceptor outer segment membrane
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
C0060090molecular_functionmolecular adaptor activity
C0097381cellular_componentphotoreceptor disc membrane
D0001750cellular_componentphotoreceptor outer segment
D0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
D0004857molecular_functionenzyme inhibitor activity
D0005515molecular_functionprotein binding
D0007601biological_processvisual perception
D0008270molecular_functionzinc ion binding
D0030553molecular_functioncGMP binding
D0042622cellular_componentphotoreceptor outer segment membrane
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
D0060090molecular_functionmolecular adaptor activity
D0097381cellular_componentphotoreceptor disc membrane
E0000035molecular_functionacyl binding
E0001664molecular_functionG protein-coupled receptor binding
E0001750cellular_componentphotoreceptor outer segment
E0001917cellular_componentphotoreceptor inner segment
E0003924molecular_functionGTPase activity
E0003925molecular_functionG protein activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005834cellular_componentheterotrimeric G-protein complex
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
E0007602biological_processphototransduction
E0007603biological_processphototransduction, visible light
E0009416biological_processresponse to light stimulus
E0016020cellular_componentmembrane
E0019001molecular_functionguanyl nucleotide binding
E0019003molecular_functionGDP binding
E0019901molecular_functionprotein kinase binding
E0031683molecular_functionG-protein beta/gamma-subunit complex binding
E0042622cellular_componentphotoreceptor outer segment membrane
E0050908biological_processdetection of light stimulus involved in visual perception
E0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
E0097381cellular_componentphotoreceptor disc membrane
E0097648cellular_componentG protein-coupled receptor complex
E0141190biological_processtransducin-mediated opsin signaling pathway
F0000035molecular_functionacyl binding
F0001664molecular_functionG protein-coupled receptor binding
F0001750cellular_componentphotoreceptor outer segment
F0001917cellular_componentphotoreceptor inner segment
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005834cellular_componentheterotrimeric G-protein complex
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
F0007602biological_processphototransduction
F0007603biological_processphototransduction, visible light
F0009416biological_processresponse to light stimulus
F0016020cellular_componentmembrane
F0019001molecular_functionguanyl nucleotide binding
F0019003molecular_functionGDP binding
F0019901molecular_functionprotein kinase binding
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0042622cellular_componentphotoreceptor outer segment membrane
F0050908biological_processdetection of light stimulus involved in visual perception
F0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
F0097381cellular_componentphotoreceptor disc membrane
F0097648cellular_componentG protein-coupled receptor complex
F0141190biological_processtransducin-mediated opsin signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDIdHrGtnNlY
ChainResidueDetails
AHIS599-TYR610
BHIS597-TYR608
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues333
DetailsDomain: {"description":"GAF 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues398
DetailsDomain: {"description":"GAF 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues666
DetailsDomain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ULG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33007200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38159849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UGS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues16
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11234020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11234020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7969474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11234020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8259210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TND","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11234020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7969474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8208289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TAG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11234020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FQK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P11488","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues36
DetailsCompositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

255900

PDB entries from 2026-07-01

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