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7JSN

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6

Functional Information from GO Data
ChainGOidnamespacecontents
A0001750cellular_componentphotoreceptor outer segment
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
A0004117molecular_functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0008081molecular_functionphosphoric diester hydrolase activity
A0016787molecular_functionhydrolase activity
A0019933biological_processcAMP-mediated signaling
A0042622cellular_componentphotoreceptor outer segment membrane
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
A0048101molecular_functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
A0060041biological_processretina development in camera-type eye
A0097381cellular_componentphotoreceptor disc membrane
B0001750cellular_componentphotoreceptor outer segment
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
B0004117molecular_functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
B0007165biological_processsignal transduction
B0007601biological_processvisual perception
B0008081molecular_functionphosphoric diester hydrolase activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019933biological_processcAMP-mediated signaling
B0042622cellular_componentphotoreceptor outer segment membrane
B0042995cellular_componentcell projection
B0043153biological_processentrainment of circadian clock by photoperiod
B0046872molecular_functionmetal ion binding
B0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
B0048101molecular_functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
B0060041biological_processretina development in camera-type eye
B0097381cellular_componentphotoreceptor disc membrane
C0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
C0004117molecular_functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
C0007601biological_processvisual perception
C0008270molecular_functionzinc ion binding
C0016787molecular_functionhydrolase activity
C0030553molecular_functioncGMP binding
C0042622cellular_componentphotoreceptor outer segment membrane
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
C0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
C0048101molecular_functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
C0060090molecular_functionmolecular adaptor activity
C0097381cellular_componentphotoreceptor disc membrane
D0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
D0004117molecular_functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
D0007601biological_processvisual perception
D0008270molecular_functionzinc ion binding
D0016787molecular_functionhydrolase activity
D0030553molecular_functioncGMP binding
D0042622cellular_componentphotoreceptor outer segment membrane
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
D0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
D0048101molecular_functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
D0060090molecular_functionmolecular adaptor activity
D0097381cellular_componentphotoreceptor disc membrane
E0000035molecular_functionacyl binding
E0001664molecular_functionG protein-coupled receptor binding
E0001750cellular_componentphotoreceptor outer segment
E0001917cellular_componentphotoreceptor inner segment
E0003924molecular_functionGTPase activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005834cellular_componentheterotrimeric G-protein complex
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
E0007601biological_processvisual perception
E0007602biological_processphototransduction
E0007603biological_processphototransduction, visible light
E0009416biological_processresponse to light stimulus
E0016020cellular_componentmembrane
E0019001molecular_functionguanyl nucleotide binding
E0019003molecular_functionGDP binding
E0019901molecular_functionprotein kinase binding
E0031683molecular_functionG-protein beta/gamma-subunit complex binding
E0042622cellular_componentphotoreceptor outer segment membrane
E0042995cellular_componentcell projection
E0046872molecular_functionmetal ion binding
E0050908biological_processdetection of light stimulus involved in visual perception
E0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
E0097381cellular_componentphotoreceptor disc membrane
E0097648cellular_componentG protein-coupled receptor complex
F0000035molecular_functionacyl binding
F0001664molecular_functionG protein-coupled receptor binding
F0001750cellular_componentphotoreceptor outer segment
F0001917cellular_componentphotoreceptor inner segment
F0003924molecular_functionGTPase activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005834cellular_componentheterotrimeric G-protein complex
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
F0007601biological_processvisual perception
F0007602biological_processphototransduction
F0007603biological_processphototransduction, visible light
F0009416biological_processresponse to light stimulus
F0016020cellular_componentmembrane
F0019001molecular_functionguanyl nucleotide binding
F0019003molecular_functionGDP binding
F0019901molecular_functionprotein kinase binding
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0042622cellular_componentphotoreceptor outer segment membrane
F0042995cellular_componentcell projection
F0046872molecular_functionmetal ion binding
F0050908biological_processdetection of light stimulus involved in visual perception
F0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
F0097381cellular_componentphotoreceptor disc membrane
F0097648cellular_componentG protein-coupled receptor complex
Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDIdHrGtnNlY
ChainResidueDetails
AHIS599-TYR610
BHIS597-TYR608

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:3011376
ChainResidueDetails
CMET1
DMET1
ELEU171
FGLY36
FASP146
FLEU171

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01230
ChainResidueDetails
ESER43
ETHR177
FSER43
FTHR177

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND
ChainResidueDetails
EGLY199
EALA322
FGLY199
FALA322

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND
ChainResidueDetails
EASN265
FASN265

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P11488
ChainResidueDetails
ETYR142
FTYR142

site_idSWS_FT_FI6
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:1436039
ChainResidueDetails
EGLY2
FGLY2

224201

PDB entries from 2024-08-28

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