7JNY

Crystal structure of CXCL13

Replaces:  4ZAI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002467	biological_process	germinal center formation
A	0002518	biological_process	lymphocyte chemotaxis across high endothelial venule
A	0002544	biological_process	chronic inflammatory response
A	0002920	biological_process	regulation of humoral immune response
A	0005125	molecular_function	cytokine activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006935	biological_process	chemotaxis
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007267	biological_process	cell-cell signaling
A	0008009	molecular_function	chemokine activity
A	0008201	molecular_function	heparin binding
A	0010820	biological_process	positive regulation of T cell chemotaxis
A	0017134	molecular_function	fibroblast growth factor binding
A	0030593	biological_process	neutrophil chemotaxis
A	0031724	molecular_function	CXCR5 chemokine receptor binding
A	0031735	molecular_function	CCR10 chemokine receptor binding
A	0032487	biological_process	regulation of Rap protein signal transduction
A	0033625	biological_process	positive regulation of integrin activation
A	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
A	0035754	biological_process	B cell chemotaxis
A	0035768	biological_process	endothelial cell chemotaxis to fibroblast growth factor
A	0042742	biological_process	defense response to bacterium
A	0045236	molecular_function	CXCR chemokine receptor binding
A	0045765	biological_process	regulation of angiogenesis
A	0048018	molecular_function	receptor ligand activity
A	0048248	molecular_function	CXCR3 chemokine receptor binding
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0071222	biological_process	cellular response to lipopolysaccharide
A	2000545	biological_process	negative regulation of endothelial cell chemotaxis to fibroblast growth factor

Functional Information from PROSITE/UniProt

site_id	PS00471
Number of Residues	46
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CrCVqessvfIprRfIdrIqilprGngCprkEIIvwkknksiv.CVD

Chain	Residue	Details
A	CYS11-ASP56

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