7JFL
Crystal structure of human phosphorylated IRF-3 bound to CBP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0000123 | cellular_component | histone acetyltransferase complex |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0000123 | cellular_component | histone acetyltransferase complex |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| C | SER2076 | |
| C | SER2079 | |
| D | SER2076 | |
| D | SER2079 | |
| B | THR244 | |
| B | THR253 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P70671 |
| Chain | Residue | Details |
| A | LYS366 | |
| B | LYS366 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22394562 |
| Chain | Residue | Details |
| A | SER385 | |
| B | SER385 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579 |
| Chain | Residue | Details |
| A | SEP386 | |
| B | SEP386 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by IKKE and TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579 |
| Chain | Residue | Details |
| A | SER396 | |
| B | SER396 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| A | SER398 | |
| B | SER398 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:20308324 |
| Chain | Residue | Details |
| A | LYS193 | |
| A | LYS360 | |
| A | LYS366 | |
| B | LYS193 | |
| B | LYS360 | |
| B | LYS366 |
