7G00

Crystal Structure of human FABP1 in complex with 2-[[3-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]carbamoyl]cyclopentene-1-carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005319	molecular_function	lipid carrier activity
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0008289	molecular_function	lipid binding
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0016209	molecular_function	antioxidant activity
A	0019216	biological_process	regulation of lipid metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0042167	biological_process	heme catabolic process
A	0070062	cellular_component	extracellular exosome
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0071456	biological_process	cellular response to hypoxia
A	0098869	biological_process	cellular oxidant detoxification
A	0140104	molecular_function	molecular carrier activity
A	1990748	biological_process	cellular detoxification
B	0005319	molecular_function	lipid carrier activity
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0008289	molecular_function	lipid binding
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0016209	molecular_function	antioxidant activity
B	0019216	biological_process	regulation of lipid metabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0042167	biological_process	heme catabolic process
B	0070062	cellular_component	extracellular exosome
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0071456	biological_process	cellular response to hypoxia
B	0098869	biological_process	cellular oxidant detoxification
B	0140104	molecular_function	molecular carrier activity
B	1990748	biological_process	cellular detoxification
C	0005319	molecular_function	lipid carrier activity
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0008289	molecular_function	lipid binding
C	0015908	biological_process	fatty acid transport
C	0015909	biological_process	long-chain fatty acid transport
C	0016209	molecular_function	antioxidant activity
C	0019216	biological_process	regulation of lipid metabolic process
C	0019433	biological_process	triglyceride catabolic process
C	0042167	biological_process	heme catabolic process
C	0070062	cellular_component	extracellular exosome
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0071456	biological_process	cellular response to hypoxia
C	0098869	biological_process	cellular oxidant detoxification
C	0140104	molecular_function	molecular carrier activity
C	1990748	biological_process	cellular detoxification
D	0005319	molecular_function	lipid carrier activity
D	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0008289	molecular_function	lipid binding
D	0015908	biological_process	fatty acid transport
D	0015909	biological_process	long-chain fatty acid transport
D	0016209	molecular_function	antioxidant activity
D	0019216	biological_process	regulation of lipid metabolic process
D	0019433	biological_process	triglyceride catabolic process
D	0042167	biological_process	heme catabolic process
D	0070062	cellular_component	extracellular exosome
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0071456	biological_process	cellular response to hypoxia
D	0098869	biological_process	cellular oxidant detoxification
D	0140104	molecular_function	molecular carrier activity
D	1990748	biological_process	cellular detoxification
E	0005319	molecular_function	lipid carrier activity
E	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
E	0005504	molecular_function	fatty acid binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0008289	molecular_function	lipid binding
E	0015908	biological_process	fatty acid transport
E	0015909	biological_process	long-chain fatty acid transport
E	0016209	molecular_function	antioxidant activity
E	0019216	biological_process	regulation of lipid metabolic process
E	0019433	biological_process	triglyceride catabolic process
E	0042167	biological_process	heme catabolic process
E	0070062	cellular_component	extracellular exosome
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0071456	biological_process	cellular response to hypoxia
E	0098869	biological_process	cellular oxidant detoxification
E	0140104	molecular_function	molecular carrier activity
E	1990748	biological_process	cellular detoxification
F	0005319	molecular_function	lipid carrier activity
F	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
F	0005504	molecular_function	fatty acid binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0008289	molecular_function	lipid binding
F	0015908	biological_process	fatty acid transport
F	0015909	biological_process	long-chain fatty acid transport
F	0016209	molecular_function	antioxidant activity
F	0019216	biological_process	regulation of lipid metabolic process
F	0019433	biological_process	triglyceride catabolic process
F	0042167	biological_process	heme catabolic process
F	0070062	cellular_component	extracellular exosome
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0071456	biological_process	cellular response to hypoxia
F	0098869	biological_process	cellular oxidant detoxification
F	0140104	molecular_function	molecular carrier activity
F	1990748	biological_process	cellular detoxification
G	0005319	molecular_function	lipid carrier activity
G	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
G	0005504	molecular_function	fatty acid binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005782	cellular_component	peroxisomal matrix
G	0005829	cellular_component	cytosol
G	0008289	molecular_function	lipid binding
G	0015908	biological_process	fatty acid transport
G	0015909	biological_process	long-chain fatty acid transport
G	0016209	molecular_function	antioxidant activity
G	0019216	biological_process	regulation of lipid metabolic process
G	0019433	biological_process	triglyceride catabolic process
G	0042167	biological_process	heme catabolic process
G	0070062	cellular_component	extracellular exosome
G	0070301	biological_process	cellular response to hydrogen peroxide
G	0071456	biological_process	cellular response to hypoxia
G	0098869	biological_process	cellular oxidant detoxification
G	0140104	molecular_function	molecular carrier activity
G	1990748	biological_process	cellular detoxification
H	0005319	molecular_function	lipid carrier activity
H	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
H	0005504	molecular_function	fatty acid binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005782	cellular_component	peroxisomal matrix
H	0005829	cellular_component	cytosol
H	0008289	molecular_function	lipid binding
H	0015908	biological_process	fatty acid transport
H	0015909	biological_process	long-chain fatty acid transport
H	0016209	molecular_function	antioxidant activity
H	0019216	biological_process	regulation of lipid metabolic process
H	0019433	biological_process	triglyceride catabolic process
H	0042167	biological_process	heme catabolic process
H	0070062	cellular_component	extracellular exosome
H	0070301	biological_process	cellular response to hydrogen peroxide
H	0071456	biological_process	cellular response to hypoxia
H	0098869	biological_process	cellular oxidant detoxification
H	0140104	molecular_function	molecular carrier activity
H	1990748	biological_process	cellular detoxification
I	0005319	molecular_function	lipid carrier activity
I	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
I	0005504	molecular_function	fatty acid binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005782	cellular_component	peroxisomal matrix
I	0005829	cellular_component	cytosol
I	0008289	molecular_function	lipid binding
I	0015908	biological_process	fatty acid transport
I	0015909	biological_process	long-chain fatty acid transport
I	0016209	molecular_function	antioxidant activity
I	0019216	biological_process	regulation of lipid metabolic process
I	0019433	biological_process	triglyceride catabolic process
I	0042167	biological_process	heme catabolic process
I	0070062	cellular_component	extracellular exosome
I	0070301	biological_process	cellular response to hydrogen peroxide
I	0071456	biological_process	cellular response to hypoxia
I	0098869	biological_process	cellular oxidant detoxification
I	0140104	molecular_function	molecular carrier activity
I	1990748	biological_process	cellular detoxification
J	0005319	molecular_function	lipid carrier activity
J	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
J	0005504	molecular_function	fatty acid binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005782	cellular_component	peroxisomal matrix
J	0005829	cellular_component	cytosol
J	0008289	molecular_function	lipid binding
J	0015908	biological_process	fatty acid transport
J	0015909	biological_process	long-chain fatty acid transport
J	0016209	molecular_function	antioxidant activity
J	0019216	biological_process	regulation of lipid metabolic process
J	0019433	biological_process	triglyceride catabolic process
J	0042167	biological_process	heme catabolic process
J	0070062	cellular_component	extracellular exosome
J	0070301	biological_process	cellular response to hydrogen peroxide
J	0071456	biological_process	cellular response to hypoxia
J	0098869	biological_process	cellular oxidant detoxification
J	0140104	molecular_function	molecular carrier activity
J	1990748	biological_process	cellular detoxification
K	0005319	molecular_function	lipid carrier activity
K	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
K	0005504	molecular_function	fatty acid binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005782	cellular_component	peroxisomal matrix
K	0005829	cellular_component	cytosol
K	0008289	molecular_function	lipid binding
K	0015908	biological_process	fatty acid transport
K	0015909	biological_process	long-chain fatty acid transport
K	0016209	molecular_function	antioxidant activity
K	0019216	biological_process	regulation of lipid metabolic process
K	0019433	biological_process	triglyceride catabolic process
K	0042167	biological_process	heme catabolic process
K	0070062	cellular_component	extracellular exosome
K	0070301	biological_process	cellular response to hydrogen peroxide
K	0071456	biological_process	cellular response to hypoxia
K	0098869	biological_process	cellular oxidant detoxification
K	0140104	molecular_function	molecular carrier activity
K	1990748	biological_process	cellular detoxification
L	0005319	molecular_function	lipid carrier activity
L	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
L	0005504	molecular_function	fatty acid binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005782	cellular_component	peroxisomal matrix
L	0005829	cellular_component	cytosol
L	0008289	molecular_function	lipid binding
L	0015908	biological_process	fatty acid transport
L	0015909	biological_process	long-chain fatty acid transport
L	0016209	molecular_function	antioxidant activity
L	0019216	biological_process	regulation of lipid metabolic process
L	0019433	biological_process	triglyceride catabolic process
L	0042167	biological_process	heme catabolic process
L	0070062	cellular_component	extracellular exosome
L	0070301	biological_process	cellular response to hydrogen peroxide
L	0071456	biological_process	cellular response to hypoxia
L	0098869	biological_process	cellular oxidant detoxification
L	0140104	molecular_function	molecular carrier activity
L	1990748	biological_process	cellular detoxification
M	0005319	molecular_function	lipid carrier activity
M	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
M	0005504	molecular_function	fatty acid binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005782	cellular_component	peroxisomal matrix
M	0005829	cellular_component	cytosol
M	0008289	molecular_function	lipid binding
M	0015908	biological_process	fatty acid transport
M	0015909	biological_process	long-chain fatty acid transport
M	0016209	molecular_function	antioxidant activity
M	0019216	biological_process	regulation of lipid metabolic process
M	0019433	biological_process	triglyceride catabolic process
M	0042167	biological_process	heme catabolic process
M	0070062	cellular_component	extracellular exosome
M	0070301	biological_process	cellular response to hydrogen peroxide
M	0071456	biological_process	cellular response to hypoxia
M	0098869	biological_process	cellular oxidant detoxification
M	0140104	molecular_function	molecular carrier activity
M	1990748	biological_process	cellular detoxification
N	0005319	molecular_function	lipid carrier activity
N	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
N	0005504	molecular_function	fatty acid binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005782	cellular_component	peroxisomal matrix
N	0005829	cellular_component	cytosol
N	0008289	molecular_function	lipid binding
N	0015908	biological_process	fatty acid transport
N	0015909	biological_process	long-chain fatty acid transport
N	0016209	molecular_function	antioxidant activity
N	0019216	biological_process	regulation of lipid metabolic process
N	0019433	biological_process	triglyceride catabolic process
N	0042167	biological_process	heme catabolic process
N	0070062	cellular_component	extracellular exosome
N	0070301	biological_process	cellular response to hydrogen peroxide
N	0071456	biological_process	cellular response to hypoxia
N	0098869	biological_process	cellular oxidant detoxification
N	0140104	molecular_function	molecular carrier activity
N	1990748	biological_process	cellular detoxification
O	0005319	molecular_function	lipid carrier activity
O	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
O	0005504	molecular_function	fatty acid binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005782	cellular_component	peroxisomal matrix
O	0005829	cellular_component	cytosol
O	0008289	molecular_function	lipid binding
O	0015908	biological_process	fatty acid transport
O	0015909	biological_process	long-chain fatty acid transport
O	0016209	molecular_function	antioxidant activity
O	0019216	biological_process	regulation of lipid metabolic process
O	0019433	biological_process	triglyceride catabolic process
O	0042167	biological_process	heme catabolic process
O	0070062	cellular_component	extracellular exosome
O	0070301	biological_process	cellular response to hydrogen peroxide
O	0071456	biological_process	cellular response to hypoxia
O	0098869	biological_process	cellular oxidant detoxification
O	0140104	molecular_function	molecular carrier activity
O	1990748	biological_process	cellular detoxification
P	0005319	molecular_function	lipid carrier activity
P	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
P	0005504	molecular_function	fatty acid binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005782	cellular_component	peroxisomal matrix
P	0005829	cellular_component	cytosol
P	0008289	molecular_function	lipid binding
P	0015908	biological_process	fatty acid transport
P	0015909	biological_process	long-chain fatty acid transport
P	0016209	molecular_function	antioxidant activity
P	0019216	biological_process	regulation of lipid metabolic process
P	0019433	biological_process	triglyceride catabolic process
P	0042167	biological_process	heme catabolic process
P	0070062	cellular_component	extracellular exosome
P	0070301	biological_process	cellular response to hydrogen peroxide
P	0071456	biological_process	cellular response to hypoxia
P	0098869	biological_process	cellular oxidant detoxification
P	0140104	molecular_function	molecular carrier activity
P	1990748	biological_process	cellular detoxification

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI

Chain	Residue	Details
A	GLY5-ILE22

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"3838309","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	112
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P12710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P12710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---