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7FYW

Crystal Structure of apo mouse FABP5, twinned in P21 with beta=90deg

Functional Information from GO Data
ChainGOidnamespacecontents
A0001972molecular_functionretinoic acid binding
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005504molecular_functionfatty acid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006006biological_processglucose metabolic process
A0006629biological_processlipid metabolic process
A0006656biological_processphosphatidylcholine biosynthetic process
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0010829biological_processnegative regulation of glucose transmembrane transport
A0014069cellular_componentpostsynaptic density
A0015909biological_processlong-chain fatty acid transport
A0031392biological_processregulation of prostaglandin biosynthetic process
A0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0045202cellular_componentsynapse
A0051930biological_processregulation of sensory perception of pain
A0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
A0098978cellular_componentglutamatergic synapse
A0099092cellular_componentpostsynaptic density, intracellular component
A0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
A0099524cellular_componentpostsynaptic cytosol
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1990379biological_processlipid transport across blood-brain barrier
B0001972molecular_functionretinoic acid binding
B0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
B0005504molecular_functionfatty acid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006006biological_processglucose metabolic process
B0006629biological_processlipid metabolic process
B0006656biological_processphosphatidylcholine biosynthetic process
B0006869biological_processlipid transport
B0008289molecular_functionlipid binding
B0010829biological_processnegative regulation of glucose transmembrane transport
B0014069cellular_componentpostsynaptic density
B0015909biological_processlong-chain fatty acid transport
B0031392biological_processregulation of prostaglandin biosynthetic process
B0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
B0042593biological_processglucose homeostasis
B0042802molecular_functionidentical protein binding
B0045202cellular_componentsynapse
B0051930biological_processregulation of sensory perception of pain
B0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
B0098978cellular_componentglutamatergic synapse
B0099092cellular_componentpostsynaptic density, intracellular component
B0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
B0099524cellular_componentpostsynaptic cytosol
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1990379biological_processlipid transport across blood-brain barrier
C0001972molecular_functionretinoic acid binding
C0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
C0005504molecular_functionfatty acid binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0006006biological_processglucose metabolic process
C0006629biological_processlipid metabolic process
C0006656biological_processphosphatidylcholine biosynthetic process
C0006869biological_processlipid transport
C0008289molecular_functionlipid binding
C0010829biological_processnegative regulation of glucose transmembrane transport
C0014069cellular_componentpostsynaptic density
C0015909biological_processlong-chain fatty acid transport
C0031392biological_processregulation of prostaglandin biosynthetic process
C0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
C0042593biological_processglucose homeostasis
C0042802molecular_functionidentical protein binding
C0045202cellular_componentsynapse
C0051930biological_processregulation of sensory perception of pain
C0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
C0098978cellular_componentglutamatergic synapse
C0099092cellular_componentpostsynaptic density, intracellular component
C0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
C0099524cellular_componentpostsynaptic cytosol
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1990379biological_processlipid transport across blood-brain barrier
D0001972molecular_functionretinoic acid binding
D0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
D0005504molecular_functionfatty acid binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0006006biological_processglucose metabolic process
D0006629biological_processlipid metabolic process
D0006656biological_processphosphatidylcholine biosynthetic process
D0006869biological_processlipid transport
D0008289molecular_functionlipid binding
D0010829biological_processnegative regulation of glucose transmembrane transport
D0014069cellular_componentpostsynaptic density
D0015909biological_processlong-chain fatty acid transport
D0031392biological_processregulation of prostaglandin biosynthetic process
D0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
D0042593biological_processglucose homeostasis
D0042802molecular_functionidentical protein binding
D0045202cellular_componentsynapse
D0051930biological_processregulation of sensory perception of pain
D0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
D0098978cellular_componentglutamatergic synapse
D0099092cellular_componentpostsynaptic density, intracellular component
D0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
D0099524cellular_componentpostsynaptic cytosol
D0120162biological_processpositive regulation of cold-induced thermogenesis
D1990379biological_processlipid transport across blood-brain barrier
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. GKWrLmeShGFEeYMKEL
ChainResidueDetails
AGLY8-LEU25

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:24531463, ECO:0007744|PDB:4AZQ
ChainResidueDetails
ACYS42
DCYS42
DTHR55
DARG108
ATHR55
AARG108
BCYS42
BTHR55
BARG108
CCYS42
CTHR55
CARG108

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:24531463, ECO:0007744|PDB:4AZP, ECO:0007744|PDB:4AZQ
ChainResidueDetails
AARG128
BARG128
CARG128
DARG128

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:24531463, ECO:0007744|PDB:4AZP
ChainResidueDetails
ATYR130
BTYR130
CTYR130
DTYR130

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q01469
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55053
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q01469
ChainResidueDetails
ATYR130
BTYR130
CTYR130
DTYR130

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PDB entries from 2024-09-11

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