Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7FY8

Crystal Structure of human FABP1 in complex with 2-[[4-cyclopropyl-5-methyl-3-[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]thiophen-2-yl]carbamoyl]cyclopentene-1-carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0008289	molecular_function	lipid binding
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0016209	molecular_function	antioxidant activity
A	0032000	biological_process	positive regulation of fatty acid beta-oxidation
A	0032052	molecular_function	bile acid binding
A	0032991	cellular_component	protein-containing complex
A	0033552	biological_process	response to vitamin B3
A	0043066	biological_process	negative regulation of apoptotic process
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0045179	cellular_component	apical cortex
A	0050892	biological_process	intestinal absorption
A	0070062	cellular_component	extracellular exosome
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070538	molecular_function	oleic acid binding
A	0071456	biological_process	cellular response to hypoxia
A	0098869	biological_process	cellular oxidant detoxification
A	1901363	molecular_function	heterocyclic compound binding
B	0003682	molecular_function	chromatin binding
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0008289	molecular_function	lipid binding
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0016209	molecular_function	antioxidant activity
B	0032000	biological_process	positive regulation of fatty acid beta-oxidation
B	0032052	molecular_function	bile acid binding
B	0032991	cellular_component	protein-containing complex
B	0033552	biological_process	response to vitamin B3
B	0043066	biological_process	negative regulation of apoptotic process
B	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B	0045179	cellular_component	apical cortex
B	0050892	biological_process	intestinal absorption
B	0070062	cellular_component	extracellular exosome
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070538	molecular_function	oleic acid binding
B	0071456	biological_process	cellular response to hypoxia
B	0098869	biological_process	cellular oxidant detoxification
B	1901363	molecular_function	heterocyclic compound binding
C	0003682	molecular_function	chromatin binding
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0008289	molecular_function	lipid binding
C	0015908	biological_process	fatty acid transport
C	0015909	biological_process	long-chain fatty acid transport
C	0016209	molecular_function	antioxidant activity
C	0032000	biological_process	positive regulation of fatty acid beta-oxidation
C	0032052	molecular_function	bile acid binding
C	0032991	cellular_component	protein-containing complex
C	0033552	biological_process	response to vitamin B3
C	0043066	biological_process	negative regulation of apoptotic process
C	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C	0045179	cellular_component	apical cortex
C	0050892	biological_process	intestinal absorption
C	0070062	cellular_component	extracellular exosome
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070538	molecular_function	oleic acid binding
C	0071456	biological_process	cellular response to hypoxia
C	0098869	biological_process	cellular oxidant detoxification
C	1901363	molecular_function	heterocyclic compound binding
D	0003682	molecular_function	chromatin binding
D	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0008289	molecular_function	lipid binding
D	0015908	biological_process	fatty acid transport
D	0015909	biological_process	long-chain fatty acid transport
D	0016209	molecular_function	antioxidant activity
D	0032000	biological_process	positive regulation of fatty acid beta-oxidation
D	0032052	molecular_function	bile acid binding
D	0032991	cellular_component	protein-containing complex
D	0033552	biological_process	response to vitamin B3
D	0043066	biological_process	negative regulation of apoptotic process
D	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D	0045179	cellular_component	apical cortex
D	0050892	biological_process	intestinal absorption
D	0070062	cellular_component	extracellular exosome
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0070538	molecular_function	oleic acid binding
D	0071456	biological_process	cellular response to hypoxia
D	0098869	biological_process	cellular oxidant detoxification
D	1901363	molecular_function	heterocyclic compound binding
E	0003682	molecular_function	chromatin binding
E	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
E	0005504	molecular_function	fatty acid binding
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0008289	molecular_function	lipid binding
E	0015908	biological_process	fatty acid transport
E	0015909	biological_process	long-chain fatty acid transport
E	0016209	molecular_function	antioxidant activity
E	0032000	biological_process	positive regulation of fatty acid beta-oxidation
E	0032052	molecular_function	bile acid binding
E	0032991	cellular_component	protein-containing complex
E	0033552	biological_process	response to vitamin B3
E	0043066	biological_process	negative regulation of apoptotic process
E	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E	0045179	cellular_component	apical cortex
E	0050892	biological_process	intestinal absorption
E	0070062	cellular_component	extracellular exosome
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0070538	molecular_function	oleic acid binding
E	0071456	biological_process	cellular response to hypoxia
E	0098869	biological_process	cellular oxidant detoxification
E	1901363	molecular_function	heterocyclic compound binding
F	0003682	molecular_function	chromatin binding
F	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
F	0005504	molecular_function	fatty acid binding
F	0005515	molecular_function	protein binding
F	0005543	molecular_function	phospholipid binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0008289	molecular_function	lipid binding
F	0015908	biological_process	fatty acid transport
F	0015909	biological_process	long-chain fatty acid transport
F	0016209	molecular_function	antioxidant activity
F	0032000	biological_process	positive regulation of fatty acid beta-oxidation
F	0032052	molecular_function	bile acid binding
F	0032991	cellular_component	protein-containing complex
F	0033552	biological_process	response to vitamin B3
F	0043066	biological_process	negative regulation of apoptotic process
F	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
F	0045179	cellular_component	apical cortex
F	0050892	biological_process	intestinal absorption
F	0070062	cellular_component	extracellular exosome
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0070538	molecular_function	oleic acid binding
F	0071456	biological_process	cellular response to hypoxia
F	0098869	biological_process	cellular oxidant detoxification
F	1901363	molecular_function	heterocyclic compound binding
G	0003682	molecular_function	chromatin binding
G	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
G	0005504	molecular_function	fatty acid binding
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005782	cellular_component	peroxisomal matrix
G	0005829	cellular_component	cytosol
G	0008289	molecular_function	lipid binding
G	0015908	biological_process	fatty acid transport
G	0015909	biological_process	long-chain fatty acid transport
G	0016209	molecular_function	antioxidant activity
G	0032000	biological_process	positive regulation of fatty acid beta-oxidation
G	0032052	molecular_function	bile acid binding
G	0032991	cellular_component	protein-containing complex
G	0033552	biological_process	response to vitamin B3
G	0043066	biological_process	negative regulation of apoptotic process
G	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
G	0045179	cellular_component	apical cortex
G	0050892	biological_process	intestinal absorption
G	0070062	cellular_component	extracellular exosome
G	0070301	biological_process	cellular response to hydrogen peroxide
G	0070538	molecular_function	oleic acid binding
G	0071456	biological_process	cellular response to hypoxia
G	0098869	biological_process	cellular oxidant detoxification
G	1901363	molecular_function	heterocyclic compound binding
H	0003682	molecular_function	chromatin binding
H	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
H	0005504	molecular_function	fatty acid binding
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005782	cellular_component	peroxisomal matrix
H	0005829	cellular_component	cytosol
H	0008289	molecular_function	lipid binding
H	0015908	biological_process	fatty acid transport
H	0015909	biological_process	long-chain fatty acid transport
H	0016209	molecular_function	antioxidant activity
H	0032000	biological_process	positive regulation of fatty acid beta-oxidation
H	0032052	molecular_function	bile acid binding
H	0032991	cellular_component	protein-containing complex
H	0033552	biological_process	response to vitamin B3
H	0043066	biological_process	negative regulation of apoptotic process
H	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
H	0045179	cellular_component	apical cortex
H	0050892	biological_process	intestinal absorption
H	0070062	cellular_component	extracellular exosome
H	0070301	biological_process	cellular response to hydrogen peroxide
H	0070538	molecular_function	oleic acid binding
H	0071456	biological_process	cellular response to hypoxia
H	0098869	biological_process	cellular oxidant detoxification
H	1901363	molecular_function	heterocyclic compound binding

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI

Chain	Residue	Details
A	GLY5-ILE22

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: N-acetylmethionine => ECO:0000269\|PubMed:3838309

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1
E	MET1
F	MET1
G	MET1
H	MET1

site_id	SWS_FT_FI2
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER11
A	SER56
B	SER11
B	SER56
C	SER11
C	SER56
D	SER11
D	SER56
E	SER11
E	SER56
F	SER11
F	SER56
G	SER11
G	SER56
H	SER11
H	SER56

site_id	SWS_FT_FI3
Number of Residues	56
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P12710

Chain	Residue	Details
A	LYS31
A	LYS36
A	LYS46
A	LYS57
A	LYS78
A	LYS90
A	LYS121
B	LYS31
B	LYS36
B	LYS46
B	LYS57
B	LYS78
B	LYS90
B	LYS121
C	LYS31
C	LYS36
C	LYS46
C	LYS57
C	LYS78
C	LYS90
C	LYS121
D	LYS31
D	LYS36
D	LYS46
D	LYS57
D	LYS78
D	LYS90
D	LYS121
E	LYS31
E	LYS36
E	LYS46
E	LYS57
E	LYS78
E	LYS90
E	LYS121
F	LYS31
F	LYS36
F	LYS46
F	LYS57
F	LYS78
F	LYS90
F	LYS121
G	LYS31
G	LYS36
G	LYS46
G	LYS57
G	LYS78
G	LYS90
G	LYS121
H	LYS31
H	LYS36
H	LYS46
H	LYS57
H	LYS78
H	LYS90
H	LYS121

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P02692

Chain	Residue	Details
A	SER39
B	SER39
C	SER39
D	SER39
E	SER39
F	SER39
G	SER39
H	SER39

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR51
B	THR51
C	THR51
D	THR51
E	THR51
F	THR51
G	THR51
H	THR51

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P12710

Chain	Residue	Details
A	SER100
B	SER100
C	SER100
D	SER100
E	SER100
F	SER100
G	SER100
H	SER100

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)