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7FXO

Crystal Structure of apo human FABP1 monoclinic form III

Functional Information from GO Data
ChainGOidnamespacecontents
A0003682molecular_functionchromatin binding
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0008289molecular_functionlipid binding
A0015908biological_processfatty acid transport
A0015909biological_processlong-chain fatty acid transport
A0016209molecular_functionantioxidant activity
A0032000biological_processpositive regulation of fatty acid beta-oxidation
A0032052molecular_functionbile acid binding
A0032991cellular_componentprotein-containing complex
A0033552biological_processresponse to vitamin B3
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0045179cellular_componentapical cortex
A0050892biological_processintestinal absorption
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0070538molecular_functionoleic acid binding
A0071456biological_processcellular response to hypoxia
A0098869biological_processcellular oxidant detoxification
A1901363molecular_functionheterocyclic compound binding
B0003682molecular_functionchromatin binding
B0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0008289molecular_functionlipid binding
B0015908biological_processfatty acid transport
B0015909biological_processlong-chain fatty acid transport
B0016209molecular_functionantioxidant activity
B0032000biological_processpositive regulation of fatty acid beta-oxidation
B0032052molecular_functionbile acid binding
B0032991cellular_componentprotein-containing complex
B0033552biological_processresponse to vitamin B3
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0045179cellular_componentapical cortex
B0050892biological_processintestinal absorption
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0070538molecular_functionoleic acid binding
B0071456biological_processcellular response to hypoxia
B0098869biological_processcellular oxidant detoxification
B1901363molecular_functionheterocyclic compound binding
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI
ChainResidueDetails
AGLY5-ILE22

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:3838309
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER11
ASER56
BSER11
BSER56

site_idSWS_FT_FI3
Number of Residues14
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P12710
ChainResidueDetails
ALYS31
BLYS46
BLYS57
BLYS78
BLYS90
BLYS121
ALYS36
ALYS46
ALYS57
ALYS78
ALYS90
ALYS121
BLYS31
BLYS36

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02692
ChainResidueDetails
ASER39
BSER39

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR51
BTHR51

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P12710
ChainResidueDetails
ASER100
BSER100

220113

PDB entries from 2024-05-22

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