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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7FWI

Crystal Structure of human FABP5 in complex with 2-(indole-1-carbonylamino)benzoic acid, i.e. SMILES c12N(C(=O)Nc3c(cccc3)C(=O)O)C=Cc1cccc2 with IC50=18.1696 microM

Functional Information from GO Data
ChainGOidnamespacecontents
A0001972molecular_functionretinoic acid binding
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006006biological_processglucose metabolic process
A0006629biological_processlipid metabolic process
A0006656biological_processphosphatidylcholine biosynthetic process
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0008544biological_processepidermis development
A0010829biological_processnegative regulation of D-glucose transmembrane transport
A0014069cellular_componentpostsynaptic density
A0015908biological_processfatty acid transport
A0015909biological_processlong-chain fatty acid transport
A0030667cellular_componentsecretory granule membrane
A0031392biological_processregulation of prostaglandin biosynthetic process
A0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
A0035578cellular_componentazurophil granule lumen
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0045202cellular_componentsynapse
A0051930biological_processregulation of sensory perception of pain
A0070062cellular_componentextracellular exosome
A0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
A0098978cellular_componentglutamatergic synapse
A0099092cellular_componentpostsynaptic density, intracellular component
A0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
A0099524cellular_componentpostsynaptic cytosol
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1990379biological_processlipid transport across blood-brain barrier
B0001972molecular_functionretinoic acid binding
B0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006006biological_processglucose metabolic process
B0006629biological_processlipid metabolic process
B0006656biological_processphosphatidylcholine biosynthetic process
B0006869biological_processlipid transport
B0008289molecular_functionlipid binding
B0008544biological_processepidermis development
B0010829biological_processnegative regulation of D-glucose transmembrane transport
B0014069cellular_componentpostsynaptic density
B0015908biological_processfatty acid transport
B0015909biological_processlong-chain fatty acid transport
B0030667cellular_componentsecretory granule membrane
B0031392biological_processregulation of prostaglandin biosynthetic process
B0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
B0035578cellular_componentazurophil granule lumen
B0042593biological_processglucose homeostasis
B0042802molecular_functionidentical protein binding
B0045202cellular_componentsynapse
B0051930biological_processregulation of sensory perception of pain
B0070062cellular_componentextracellular exosome
B0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
B0098978cellular_componentglutamatergic synapse
B0099092cellular_componentpostsynaptic density, intracellular component
B0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
B0099524cellular_componentpostsynaptic cytosol
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1990379biological_processlipid transport across blood-brain barrier
C0001972molecular_functionretinoic acid binding
C0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006006biological_processglucose metabolic process
C0006629biological_processlipid metabolic process
C0006656biological_processphosphatidylcholine biosynthetic process
C0006869biological_processlipid transport
C0008289molecular_functionlipid binding
C0008544biological_processepidermis development
C0010829biological_processnegative regulation of D-glucose transmembrane transport
C0014069cellular_componentpostsynaptic density
C0015908biological_processfatty acid transport
C0015909biological_processlong-chain fatty acid transport
C0030667cellular_componentsecretory granule membrane
C0031392biological_processregulation of prostaglandin biosynthetic process
C0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
C0035578cellular_componentazurophil granule lumen
C0042593biological_processglucose homeostasis
C0042802molecular_functionidentical protein binding
C0045202cellular_componentsynapse
C0051930biological_processregulation of sensory perception of pain
C0070062cellular_componentextracellular exosome
C0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
C0098978cellular_componentglutamatergic synapse
C0099092cellular_componentpostsynaptic density, intracellular component
C0099178biological_processregulation of retrograde trans-synaptic signaling by endocanabinoid
C0099524cellular_componentpostsynaptic cytosol
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1990379biological_processlipid transport across blood-brain barrier
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. GRWrLvdSkGFDeYMKEL
ChainResidueDetails
AGLY9-LEU26
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues30
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"24692551","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24531463","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AZR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24692551","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LKT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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