Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7FWI

Crystal Structure of human FABP5 in complex with 2-(indole-1-carbonylamino)benzoic acid, i.e. SMILES c12N(C(=O)Nc3c(cccc3)C(=O)O)C=Cc1cccc2 with IC50=18.1696 microM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001972	molecular_function	retinoic acid binding
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0010829	biological_process	negative regulation of D-glucose transmembrane transport
A	0014069	cellular_component	postsynaptic density
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0030667	cellular_component	secretory granule membrane
A	0031392	biological_process	regulation of prostaglandin biosynthetic process
A	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
A	0035578	cellular_component	azurophil granule lumen
A	0042593	biological_process	glucose homeostasis
A	0042802	molecular_function	identical protein binding
A	0045202	cellular_component	synapse
A	0051930	biological_process	regulation of sensory perception of pain
A	0070062	cellular_component	extracellular exosome
A	0098921	biological_process	retrograde trans-synaptic signaling by endocannabinoid
A	0098978	cellular_component	glutamatergic synapse
A	0099092	cellular_component	postsynaptic density, intracellular component
A	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
A	0099524	cellular_component	postsynaptic cytosol
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1990379	biological_process	lipid transport across blood-brain barrier
B	0001972	molecular_function	retinoic acid binding
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006006	biological_process	glucose metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0010829	biological_process	negative regulation of D-glucose transmembrane transport
B	0014069	cellular_component	postsynaptic density
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0030667	cellular_component	secretory granule membrane
B	0031392	biological_process	regulation of prostaglandin biosynthetic process
B	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
B	0035578	cellular_component	azurophil granule lumen
B	0042593	biological_process	glucose homeostasis
B	0042802	molecular_function	identical protein binding
B	0045202	cellular_component	synapse
B	0051930	biological_process	regulation of sensory perception of pain
B	0070062	cellular_component	extracellular exosome
B	0098921	biological_process	retrograde trans-synaptic signaling by endocannabinoid
B	0098978	cellular_component	glutamatergic synapse
B	0099092	cellular_component	postsynaptic density, intracellular component
B	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
B	0099524	cellular_component	postsynaptic cytosol
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	1990379	biological_process	lipid transport across blood-brain barrier
C	0001972	molecular_function	retinoic acid binding
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006629	biological_process	lipid metabolic process
C	0006656	biological_process	phosphatidylcholine biosynthetic process
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0008544	biological_process	epidermis development
C	0010829	biological_process	negative regulation of D-glucose transmembrane transport
C	0014069	cellular_component	postsynaptic density
C	0015908	biological_process	fatty acid transport
C	0015909	biological_process	long-chain fatty acid transport
C	0030667	cellular_component	secretory granule membrane
C	0031392	biological_process	regulation of prostaglandin biosynthetic process
C	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
C	0035578	cellular_component	azurophil granule lumen
C	0042593	biological_process	glucose homeostasis
C	0042802	molecular_function	identical protein binding
C	0045202	cellular_component	synapse
C	0051930	biological_process	regulation of sensory perception of pain
C	0070062	cellular_component	extracellular exosome
C	0098921	biological_process	retrograde trans-synaptic signaling by endocannabinoid
C	0098978	cellular_component	glutamatergic synapse
C	0099092	cellular_component	postsynaptic density, intracellular component
C	0099178	biological_process	regulation of retrograde trans-synaptic signaling by endocanabinoid
C	0099524	cellular_component	postsynaptic cytosol
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	1990379	biological_process	lipid transport across blood-brain barrier

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GRWrLvdSkGFDeYMKEL

Chain	Residue	Details
A	GLY9-LEU26

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:24531463, ECO:0007744\|PDB:4AZR

Chain	Residue	Details
A	CYS43
A	ARG109
A	TYR131
B	CYS43
B	ARG109
B	TYR131
C	CYS43
C	ARG109
C	TYR131

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:24692551, ECO:0007744\|PDB:4LKT

Chain	Residue	Details
A	ARG129
B	ARG129
C	ARG129

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:12665801, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS17
B	LYS17
C	LYS17

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
A	TYR131
B	TYR131
C	TYR131

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)