Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7FQH

Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-5-amino-5-oxopent-1-yn-3-yl]-1-[1-[4-(cyclopropylmethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
A	0003014	biological_process	renal system process
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005770	cellular_component	late endosome
A	0006508	biological_process	proteolysis
A	0006624	biological_process	vacuolar protein processing
A	0007613	biological_process	memory
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008306	biological_process	associative learning
A	0010447	biological_process	response to acidic pH
A	0010629	biological_process	negative regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0032801	biological_process	receptor catabolic process
A	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
A	0036021	cellular_component	endolysosome lumen
A	0040015	biological_process	negative regulation of multicellular organism growth
A	0042359	biological_process	vitamin D metabolic process
A	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
A	0043202	cellular_component	lysosomal lumen
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045177	cellular_component	apical part of cell
A	0045931	biological_process	positive regulation of mitotic cell cycle
A	0048156	molecular_function	tau protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051604	biological_process	protein maturation
A	0061133	molecular_function	endopeptidase activator activity
A	0070062	cellular_component	extracellular exosome
A	0071277	biological_process	cellular response to calcium ion
A	0090026	biological_process	positive regulation of monocyte chemotaxis
A	0097061	biological_process	dendritic spine organization
A	1900273	biological_process	positive regulation of long-term synaptic potentiation
A	1901185	biological_process	negative regulation of ERBB signaling pathway
A	1904646	biological_process	cellular response to amyloid-beta
A	2001028	biological_process	positive regulation of endothelial cell chemotaxis
B	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
B	0003014	biological_process	renal system process
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005770	cellular_component	late endosome
B	0006508	biological_process	proteolysis
B	0006624	biological_process	vacuolar protein processing
B	0007613	biological_process	memory
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008306	biological_process	associative learning
B	0010447	biological_process	response to acidic pH
B	0010629	biological_process	negative regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0032801	biological_process	receptor catabolic process
B	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
B	0036021	cellular_component	endolysosome lumen
B	0040015	biological_process	negative regulation of multicellular organism growth
B	0042359	biological_process	vitamin D metabolic process
B	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
B	0043202	cellular_component	lysosomal lumen
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0045177	cellular_component	apical part of cell
B	0045931	biological_process	positive regulation of mitotic cell cycle
B	0048156	molecular_function	tau protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0051604	biological_process	protein maturation
B	0061133	molecular_function	endopeptidase activator activity
B	0070062	cellular_component	extracellular exosome
B	0071277	biological_process	cellular response to calcium ion
B	0090026	biological_process	positive regulation of monocyte chemotaxis
B	0097061	biological_process	dendritic spine organization
B	1900273	biological_process	positive regulation of long-term synaptic potentiation
B	1901185	biological_process	negative regulation of ERBB signaling pathway
B	1904646	biological_process	cellular response to amyloid-beta
B	2001028	biological_process	positive regulation of endothelial cell chemotaxis
D	0002479	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
D	0003014	biological_process	renal system process
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005770	cellular_component	late endosome
D	0006508	biological_process	proteolysis
D	0006624	biological_process	vacuolar protein processing
D	0007613	biological_process	memory
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008306	biological_process	associative learning
D	0010447	biological_process	response to acidic pH
D	0010629	biological_process	negative regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0032801	biological_process	receptor catabolic process
D	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
D	0036021	cellular_component	endolysosome lumen
D	0040015	biological_process	negative regulation of multicellular organism growth
D	0042359	biological_process	vitamin D metabolic process
D	0042590	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I
D	0043202	cellular_component	lysosomal lumen
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0045177	cellular_component	apical part of cell
D	0045931	biological_process	positive regulation of mitotic cell cycle
D	0048156	molecular_function	tau protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0051604	biological_process	protein maturation
D	0061133	molecular_function	endopeptidase activator activity
D	0070062	cellular_component	extracellular exosome
D	0071277	biological_process	cellular response to calcium ion
D	0090026	biological_process	positive regulation of monocyte chemotaxis
D	0097061	biological_process	dendritic spine organization
D	1900273	biological_process	positive regulation of long-term synaptic potentiation
D	1901185	biological_process	negative regulation of ERBB signaling pathway
D	1904646	biological_process	cellular response to amyloid-beta
D	2001028	biological_process	positive regulation of endothelial cell chemotaxis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)