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7FQH

Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-5-amino-5-oxopent-1-yn-3-yl]-1-[1-[4-(cyclopropylmethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003014biological_processrenal system process
A0004175molecular_functionendopeptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005770cellular_componentlate endosome
A0006508biological_processproteolysis
A0006624biological_processvacuolar protein processing
A0007613biological_processmemory
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0008284biological_processpositive regulation of cell population proliferation
A0008306biological_processassociative learning
A0010447biological_processresponse to acidic pH
A0010629biological_processnegative regulation of gene expression
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0032801biological_processreceptor catabolic process
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0036021cellular_componentendolysosome lumen
A0040015biological_processnegative regulation of multicellular organism growth
A0042359biological_processvitamin D metabolic process
A0043202cellular_componentlysosomal lumen
A0043524biological_processnegative regulation of neuron apoptotic process
A0045177cellular_componentapical part of cell
A0045931biological_processpositive regulation of mitotic cell cycle
A0048156molecular_functiontau protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051603biological_processproteolysis involved in protein catabolic process
A0051604biological_processprotein maturation
A0061133molecular_functionendopeptidase activator activity
A0070062cellular_componentextracellular exosome
A0071277biological_processcellular response to calcium ion
A0090026biological_processpositive regulation of monocyte chemotaxis
A0097061biological_processdendritic spine organization
A0097202biological_processactivation of cysteine-type endopeptidase activity
A0097264biological_processself proteolysis
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1901185biological_processnegative regulation of ERBB signaling pathway
A1904646biological_processcellular response to amyloid-beta
A2001028biological_processpositive regulation of endothelial cell chemotaxis
B0003014biological_processrenal system process
B0004175molecular_functionendopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005770cellular_componentlate endosome
B0006508biological_processproteolysis
B0006624biological_processvacuolar protein processing
B0007613biological_processmemory
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0008284biological_processpositive regulation of cell population proliferation
B0008306biological_processassociative learning
B0010447biological_processresponse to acidic pH
B0010629biological_processnegative regulation of gene expression
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0032801biological_processreceptor catabolic process
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0036021cellular_componentendolysosome lumen
B0040015biological_processnegative regulation of multicellular organism growth
B0042359biological_processvitamin D metabolic process
B0043202cellular_componentlysosomal lumen
B0043524biological_processnegative regulation of neuron apoptotic process
B0045177cellular_componentapical part of cell
B0045931biological_processpositive regulation of mitotic cell cycle
B0048156molecular_functiontau protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051603biological_processproteolysis involved in protein catabolic process
B0051604biological_processprotein maturation
B0061133molecular_functionendopeptidase activator activity
B0070062cellular_componentextracellular exosome
B0071277biological_processcellular response to calcium ion
B0090026biological_processpositive regulation of monocyte chemotaxis
B0097061biological_processdendritic spine organization
B0097202biological_processactivation of cysteine-type endopeptidase activity
B0097264biological_processself proteolysis
B1900273biological_processpositive regulation of long-term synaptic potentiation
B1901185biological_processnegative regulation of ERBB signaling pathway
B1904646biological_processcellular response to amyloid-beta
B2001028biological_processpositive regulation of endothelial cell chemotaxis
D0003014biological_processrenal system process
D0004175molecular_functionendopeptidase activity
D0004197molecular_functioncysteine-type endopeptidase activity
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005770cellular_componentlate endosome
D0006508biological_processproteolysis
D0006624biological_processvacuolar protein processing
D0007613biological_processmemory
D0008233molecular_functionpeptidase activity
D0008234molecular_functioncysteine-type peptidase activity
D0008284biological_processpositive regulation of cell population proliferation
D0008306biological_processassociative learning
D0010447biological_processresponse to acidic pH
D0010629biological_processnegative regulation of gene expression
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0032801biological_processreceptor catabolic process
D0035729biological_processcellular response to hepatocyte growth factor stimulus
D0036021cellular_componentendolysosome lumen
D0040015biological_processnegative regulation of multicellular organism growth
D0042359biological_processvitamin D metabolic process
D0043202cellular_componentlysosomal lumen
D0043524biological_processnegative regulation of neuron apoptotic process
D0045177cellular_componentapical part of cell
D0045931biological_processpositive regulation of mitotic cell cycle
D0048156molecular_functiontau protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0051603biological_processproteolysis involved in protein catabolic process
D0051604biological_processprotein maturation
D0061133molecular_functionendopeptidase activator activity
D0070062cellular_componentextracellular exosome
D0071277biological_processcellular response to calcium ion
D0090026biological_processpositive regulation of monocyte chemotaxis
D0097061biological_processdendritic spine organization
D0097202biological_processactivation of cysteine-type endopeptidase activity
D0097264biological_processself proteolysis
D1900273biological_processpositive regulation of long-term synaptic potentiation
D1901185biological_processnegative regulation of ERBB signaling pathway
D1904646biological_processcellular response to amyloid-beta
D2001028biological_processpositive regulation of endothelial cell chemotaxis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:23776206
ChainResidueDetails
AHIS148
BHIS148
DHIS148

site_idSWS_FT_FI2
Number of Residues3
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:23776206
ChainResidueDetails
ACYS189
BCYS189
DCYS189

site_idSWS_FT_FI3
Number of Residues3
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:11085925
ChainResidueDetails
AASN323
BASN323
DASN323

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23776206
ChainResidueDetails
AASN91
AASN167
BASN91
BASN167
DASN91
DASN167

site_idSWS_FT_FI5
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23776206
ChainResidueDetails
AASN263
AGLN272
BASN263
BGLN272
DASN263
DGLN272

221716

PDB entries from 2024-06-26

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