Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7FDC

CryoEM Structures of Reconstituted V-ATPase, state3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0046034	biological_process	ATP metabolic process
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0000329	cellular_component	fungal-type vacuole membrane
B	0000425	biological_process	pexophagy
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005773	cellular_component	vacuole
B	0005774	cellular_component	vacuolar membrane
B	0006811	biological_process	monoatomic ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0007035	biological_process	vacuolar acidification
B	0010494	cellular_component	cytoplasmic stress granule
B	0016020	cellular_component	membrane
B	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
B	0033176	cellular_component	proton-transporting V-type ATPase complex
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0046034	biological_process	ATP metabolic process
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	0048388	biological_process	endosomal lumen acidification
B	0055085	biological_process	transmembrane transport
B	0061795	biological_process	Golgi lumen acidification
B	1902600	biological_process	proton transmembrane transport
B	1902906	biological_process	proteasome storage granule assembly
B	1990816	cellular_component	vacuole-mitochondrion membrane contact site
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0046034	biological_process	ATP metabolic process
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0000329	cellular_component	fungal-type vacuole membrane
D	0000425	biological_process	pexophagy
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005773	cellular_component	vacuole
D	0005774	cellular_component	vacuolar membrane
D	0006811	biological_process	monoatomic ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0007035	biological_process	vacuolar acidification
D	0010494	cellular_component	cytoplasmic stress granule
D	0016020	cellular_component	membrane
D	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0055085	biological_process	transmembrane transport
D	0061795	biological_process	Golgi lumen acidification
D	1902600	biological_process	proton transmembrane transport
D	1902906	biological_process	proteasome storage granule assembly
D	1990816	cellular_component	vacuole-mitochondrion membrane contact site
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0000329	cellular_component	fungal-type vacuole membrane
F	0000425	biological_process	pexophagy
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005773	cellular_component	vacuole
F	0005774	cellular_component	vacuolar membrane
F	0006811	biological_process	monoatomic ion transport
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0007035	biological_process	vacuolar acidification
F	0010494	cellular_component	cytoplasmic stress granule
F	0016020	cellular_component	membrane
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0055085	biological_process	transmembrane transport
F	0061795	biological_process	Golgi lumen acidification
F	1902600	biological_process	proton transmembrane transport
F	1902906	biological_process	proteasome storage granule assembly
F	1990816	cellular_component	vacuole-mitochondrion membrane contact site
G	0000139	cellular_component	Golgi membrane
G	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005515	molecular_function	protein binding
G	0005773	cellular_component	vacuole
G	0005774	cellular_component	vacuolar membrane
G	0006811	biological_process	monoatomic ion transport
G	0007035	biological_process	vacuolar acidification
G	0016020	cellular_component	membrane
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0048388	biological_process	endosomal lumen acidification
G	0061795	biological_process	Golgi lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0000329	cellular_component	fungal-type vacuole membrane
H	0005515	molecular_function	protein binding
H	0005773	cellular_component	vacuole
H	0005774	cellular_component	vacuolar membrane
H	0006811	biological_process	monoatomic ion transport
H	0007035	biological_process	vacuolar acidification
H	0016020	cellular_component	membrane
H	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
H	0016887	molecular_function	ATP hydrolysis activity
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0061795	biological_process	Golgi lumen acidification
H	1902600	biological_process	proton transmembrane transport
I	0000139	cellular_component	Golgi membrane
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0000329	cellular_component	fungal-type vacuole membrane
I	0005515	molecular_function	protein binding
I	0005773	cellular_component	vacuole
I	0005774	cellular_component	vacuolar membrane
I	0006811	biological_process	monoatomic ion transport
I	0007035	biological_process	vacuolar acidification
I	0016020	cellular_component	membrane
I	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
I	0033176	cellular_component	proton-transporting V-type ATPase complex
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0048388	biological_process	endosomal lumen acidification
I	0061795	biological_process	Golgi lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0000139	cellular_component	Golgi membrane
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0000329	cellular_component	fungal-type vacuole membrane
J	0005515	molecular_function	protein binding
J	0005773	cellular_component	vacuole
J	0005774	cellular_component	vacuolar membrane
J	0006811	biological_process	monoatomic ion transport
J	0007035	biological_process	vacuolar acidification
J	0016020	cellular_component	membrane
J	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
J	0016887	molecular_function	ATP hydrolysis activity
J	0033176	cellular_component	proton-transporting V-type ATPase complex
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0048388	biological_process	endosomal lumen acidification
J	0061795	biological_process	Golgi lumen acidification
J	1902600	biological_process	proton transmembrane transport
K	0000139	cellular_component	Golgi membrane
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0000329	cellular_component	fungal-type vacuole membrane
K	0005515	molecular_function	protein binding
K	0005773	cellular_component	vacuole
K	0005774	cellular_component	vacuolar membrane
K	0006811	biological_process	monoatomic ion transport
K	0007035	biological_process	vacuolar acidification
K	0016020	cellular_component	membrane
K	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
K	0033176	cellular_component	proton-transporting V-type ATPase complex
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0048388	biological_process	endosomal lumen acidification
K	0061795	biological_process	Golgi lumen acidification
K	1902600	biological_process	proton transmembrane transport
L	0000139	cellular_component	Golgi membrane
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0000329	cellular_component	fungal-type vacuole membrane
L	0005515	molecular_function	protein binding
L	0005773	cellular_component	vacuole
L	0005774	cellular_component	vacuolar membrane
L	0006811	biological_process	monoatomic ion transport
L	0007035	biological_process	vacuolar acidification
L	0016020	cellular_component	membrane
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0016887	molecular_function	ATP hydrolysis activity
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0048388	biological_process	endosomal lumen acidification
L	0061795	biological_process	Golgi lumen acidification
L	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005515	molecular_function	protein binding
M	0005773	cellular_component	vacuole
M	0005774	cellular_component	vacuolar membrane
M	0006811	biological_process	monoatomic ion transport
M	0007035	biological_process	vacuolar acidification
M	0016020	cellular_component	membrane
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0061795	biological_process	Golgi lumen acidification
M	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005515	molecular_function	protein binding
N	0005773	cellular_component	vacuole
N	0005774	cellular_component	vacuolar membrane
N	0006811	biological_process	monoatomic ion transport
N	0007035	biological_process	vacuolar acidification
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0034220	biological_process	monoatomic ion transmembrane transport
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0061795	biological_process	Golgi lumen acidification
N	1902600	biological_process	proton transmembrane transport
O	0000139	cellular_component	Golgi membrane
O	0000166	molecular_function	nucleotide binding
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0000329	cellular_component	fungal-type vacuole membrane
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005773	cellular_component	vacuole
O	0005774	cellular_component	vacuolar membrane
O	0006811	biological_process	monoatomic ion transport
O	0007035	biological_process	vacuolar acidification
O	0015078	molecular_function	proton transmembrane transporter activity
O	0016020	cellular_component	membrane
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0033176	cellular_component	proton-transporting V-type ATPase complex
O	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0048388	biological_process	endosomal lumen acidification
O	0061795	biological_process	Golgi lumen acidification
O	1902600	biological_process	proton transmembrane transport
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Q	0000324	cellular_component	fungal-type vacuole
Q	0000329	cellular_component	fungal-type vacuole membrane
Q	0005515	molecular_function	protein binding
Q	0005773	cellular_component	vacuole
Q	0005774	cellular_component	vacuolar membrane
Q	0005886	cellular_component	plasma membrane
Q	0006797	biological_process	polyphosphate metabolic process
Q	0006811	biological_process	monoatomic ion transport
Q	0007035	biological_process	vacuolar acidification
Q	0016020	cellular_component	membrane
Q	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Q	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	0051117	molecular_function	ATPase binding
Q	0065003	biological_process	protein-containing complex assembly
Q	0071469	biological_process	cellular response to alkaline pH
Q	0071474	biological_process	cellular hyperosmotic response
Q	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
Q	1902600	biological_process	proton transmembrane transport
S	0000139	cellular_component	Golgi membrane
S	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
S	0000329	cellular_component	fungal-type vacuole membrane
S	0005515	molecular_function	protein binding
S	0005769	cellular_component	early endosome
S	0005773	cellular_component	vacuole
S	0005774	cellular_component	vacuolar membrane
S	0006811	biological_process	monoatomic ion transport
S	0007034	biological_process	vacuolar transport
S	0007035	biological_process	vacuolar acidification
S	0016020	cellular_component	membrane
S	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
S	0033176	cellular_component	proton-transporting V-type ATPase complex
S	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
S	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	0048388	biological_process	endosomal lumen acidification
S	0061795	biological_process	Golgi lumen acidification
S	1902600	biological_process	proton transmembrane transport
T	0000139	cellular_component	Golgi membrane
T	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
T	0000329	cellular_component	fungal-type vacuole membrane
T	0005773	cellular_component	vacuole
T	0005774	cellular_component	vacuolar membrane
T	0006811	biological_process	monoatomic ion transport
T	0007035	biological_process	vacuolar acidification
T	0008553	molecular_function	P-type proton-exporting transporter activity
T	0015078	molecular_function	proton transmembrane transporter activity
T	0016020	cellular_component	membrane
T	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
T	0033176	cellular_component	proton-transporting V-type ATPase complex
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
T	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
T	0048388	biological_process	endosomal lumen acidification
T	0061795	biological_process	Golgi lumen acidification
T	1902600	biological_process	proton transmembrane transport
U	0000139	cellular_component	Golgi membrane
U	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
U	0000324	cellular_component	fungal-type vacuole
U	0000329	cellular_component	fungal-type vacuole membrane
U	0005773	cellular_component	vacuole
U	0005774	cellular_component	vacuolar membrane
U	0006811	biological_process	monoatomic ion transport
U	0007035	biological_process	vacuolar acidification
U	0015078	molecular_function	proton transmembrane transporter activity
U	0016020	cellular_component	membrane
U	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
U	0033176	cellular_component	proton-transporting V-type ATPase complex
U	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
U	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
U	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
U	0048388	biological_process	endosomal lumen acidification
U	0061795	biological_process	Golgi lumen acidification
U	0071944	cellular_component	cell periphery
U	1902600	biological_process	proton transmembrane transport
V	0000139	cellular_component	Golgi membrane
V	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
V	0000329	cellular_component	fungal-type vacuole membrane
V	0005773	cellular_component	vacuole
V	0005774	cellular_component	vacuolar membrane
V	0006623	biological_process	protein targeting to vacuole
V	0006811	biological_process	monoatomic ion transport
V	0006878	biological_process	intracellular copper ion homeostasis
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006897	biological_process	endocytosis
V	0007033	biological_process	vacuole organization
V	0007035	biological_process	vacuolar acidification
V	0015078	molecular_function	proton transmembrane transporter activity
V	0016020	cellular_component	membrane
V	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
V	0033176	cellular_component	proton-transporting V-type ATPase complex
V	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
V	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
V	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
V	0048388	biological_process	endosomal lumen acidification
V	0061795	biological_process	Golgi lumen acidification
V	1902600	biological_process	proton transmembrane transport
W	0000139	cellular_component	Golgi membrane
W	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
W	0000329	cellular_component	fungal-type vacuole membrane
W	0005773	cellular_component	vacuole
W	0005774	cellular_component	vacuolar membrane
W	0006623	biological_process	protein targeting to vacuole
W	0006811	biological_process	monoatomic ion transport
W	0006878	biological_process	intracellular copper ion homeostasis
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006897	biological_process	endocytosis
W	0007033	biological_process	vacuole organization
W	0007035	biological_process	vacuolar acidification
W	0015078	molecular_function	proton transmembrane transporter activity
W	0016020	cellular_component	membrane
W	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
W	0033176	cellular_component	proton-transporting V-type ATPase complex
W	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
W	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
W	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
W	0048388	biological_process	endosomal lumen acidification
W	0061795	biological_process	Golgi lumen acidification
W	1902600	biological_process	proton transmembrane transport
X	0000139	cellular_component	Golgi membrane
X	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
X	0000329	cellular_component	fungal-type vacuole membrane
X	0005773	cellular_component	vacuole
X	0005774	cellular_component	vacuolar membrane
X	0006623	biological_process	protein targeting to vacuole
X	0006811	biological_process	monoatomic ion transport
X	0006878	biological_process	intracellular copper ion homeostasis
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006897	biological_process	endocytosis
X	0007033	biological_process	vacuole organization
X	0007035	biological_process	vacuolar acidification
X	0015078	molecular_function	proton transmembrane transporter activity
X	0016020	cellular_component	membrane
X	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
X	0033176	cellular_component	proton-transporting V-type ATPase complex
X	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
X	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
X	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
X	0048388	biological_process	endosomal lumen acidification
X	0061795	biological_process	Golgi lumen acidification
X	1902600	biological_process	proton transmembrane transport
Y	0000139	cellular_component	Golgi membrane
Y	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Y	0000329	cellular_component	fungal-type vacuole membrane
Y	0005773	cellular_component	vacuole
Y	0005774	cellular_component	vacuolar membrane
Y	0006623	biological_process	protein targeting to vacuole
Y	0006811	biological_process	monoatomic ion transport
Y	0006878	biological_process	intracellular copper ion homeostasis
Y	0006879	biological_process	intracellular iron ion homeostasis
Y	0006897	biological_process	endocytosis
Y	0007033	biological_process	vacuole organization
Y	0007035	biological_process	vacuolar acidification
Y	0015078	molecular_function	proton transmembrane transporter activity
Y	0016020	cellular_component	membrane
Y	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Y	0033176	cellular_component	proton-transporting V-type ATPase complex
Y	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Y	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Y	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Y	0048388	biological_process	endosomal lumen acidification
Y	0061795	biological_process	Golgi lumen acidification
Y	1902600	biological_process	proton transmembrane transport
Z	0000139	cellular_component	Golgi membrane
Z	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Z	0000329	cellular_component	fungal-type vacuole membrane
Z	0005773	cellular_component	vacuole
Z	0005774	cellular_component	vacuolar membrane
Z	0006623	biological_process	protein targeting to vacuole
Z	0006811	biological_process	monoatomic ion transport
Z	0006878	biological_process	intracellular copper ion homeostasis
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006897	biological_process	endocytosis
Z	0007033	biological_process	vacuole organization
Z	0007035	biological_process	vacuolar acidification
Z	0015078	molecular_function	proton transmembrane transporter activity
Z	0016020	cellular_component	membrane
Z	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Z	0033176	cellular_component	proton-transporting V-type ATPase complex
Z	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Z	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Z	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Z	0048388	biological_process	endosomal lumen acidification
Z	0061795	biological_process	Golgi lumen acidification
Z	1902600	biological_process	proton transmembrane transport
a	0000139	cellular_component	Golgi membrane
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0000329	cellular_component	fungal-type vacuole membrane
a	0005773	cellular_component	vacuole
a	0005774	cellular_component	vacuolar membrane
a	0006623	biological_process	protein targeting to vacuole
a	0006811	biological_process	monoatomic ion transport
a	0006878	biological_process	intracellular copper ion homeostasis
a	0006879	biological_process	intracellular iron ion homeostasis
a	0006897	biological_process	endocytosis
a	0007033	biological_process	vacuole organization
a	0007035	biological_process	vacuolar acidification
a	0015078	molecular_function	proton transmembrane transporter activity
a	0016020	cellular_component	membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0033176	cellular_component	proton-transporting V-type ATPase complex
a	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0048388	biological_process	endosomal lumen acidification
a	0061795	biological_process	Golgi lumen acidification
a	1902600	biological_process	proton transmembrane transport
b	0000139	cellular_component	Golgi membrane
b	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
b	0000329	cellular_component	fungal-type vacuole membrane
b	0005773	cellular_component	vacuole
b	0005774	cellular_component	vacuolar membrane
b	0006623	biological_process	protein targeting to vacuole
b	0006811	biological_process	monoatomic ion transport
b	0006878	biological_process	intracellular copper ion homeostasis
b	0006879	biological_process	intracellular iron ion homeostasis
b	0006897	biological_process	endocytosis
b	0007033	biological_process	vacuole organization
b	0007035	biological_process	vacuolar acidification
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
b	0033176	cellular_component	proton-transporting V-type ATPase complex
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	0048388	biological_process	endosomal lumen acidification
b	0061795	biological_process	Golgi lumen acidification
b	1902600	biological_process	proton transmembrane transport
c	0000139	cellular_component	Golgi membrane
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0000329	cellular_component	fungal-type vacuole membrane
c	0005773	cellular_component	vacuole
c	0005774	cellular_component	vacuolar membrane
c	0006623	biological_process	protein targeting to vacuole
c	0006811	biological_process	monoatomic ion transport
c	0006878	biological_process	intracellular copper ion homeostasis
c	0006879	biological_process	intracellular iron ion homeostasis
c	0006897	biological_process	endocytosis
c	0007033	biological_process	vacuole organization
c	0007035	biological_process	vacuolar acidification
c	0015078	molecular_function	proton transmembrane transporter activity
c	0016020	cellular_component	membrane
c	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
c	0033176	cellular_component	proton-transporting V-type ATPase complex
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0048388	biological_process	endosomal lumen acidification
c	0061795	biological_process	Golgi lumen acidification
c	1902600	biological_process	proton transmembrane transport
d	0000032	biological_process	cell wall mannoprotein biosynthetic process
d	0000139	cellular_component	Golgi membrane
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0000329	cellular_component	fungal-type vacuole membrane
d	0005773	cellular_component	vacuole
d	0005774	cellular_component	vacuolar membrane
d	0006811	biological_process	monoatomic ion transport
d	0007035	biological_process	vacuolar acidification
d	0016020	cellular_component	membrane
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
d	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0048388	biological_process	endosomal lumen acidification
d	0055085	biological_process	transmembrane transport
d	0061795	biological_process	Golgi lumen acidification
d	0065003	biological_process	protein-containing complex assembly
d	1902600	biological_process	proton transmembrane transport
f	0000139	cellular_component	Golgi membrane
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0000329	cellular_component	fungal-type vacuole membrane
f	0003674	molecular_function	molecular_function
f	0004521	molecular_function	RNA endonuclease activity
f	0005575	cellular_component	cellular_component
f	0005773	cellular_component	vacuole
f	0005774	cellular_component	vacuolar membrane
f	0005783	cellular_component	endoplasmic reticulum
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0007035	biological_process	vacuolar acidification
f	0008150	biological_process	biological_process
f	0016020	cellular_component	membrane
f	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
f	0033176	cellular_component	proton-transporting V-type ATPase complex
f	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
f	0048388	biological_process	endosomal lumen acidification
f	0061795	biological_process	Golgi lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PSINTSVSYS

Chain	Residue	Details
A	PRO452-SER461
B	PRO371-SER380

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N-acetylserine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
H	SER2
Y	MET1-TYR8
Y	CYS75-GLN90
Y	ASN151-CYS160
Z	MET1-TYR8
Z	CYS75-GLN90
Z	ASN151-CYS160
a	MET1-TYR8
a	CYS75-GLN90
a	ASN151-CYS160
b	MET1-TYR8
J	SER2
b	CYS75-GLN90
b	ASN151-CYS160
c	MET1-TYR8
c	CYS75-GLN90
c	ASN151-CYS160
L	SER2
W	MET1-TYR8
W	CYS75-GLN90
W	ASN151-CYS160
X	MET1-TYR8
X	CYS75-GLN90
X	ASN151-CYS160

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.6, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	ALA1
X	ILE54-VAL74
X	LEU91-GLY112
X	LEU125-LEU150
Y	ALA9-GLY31
Y	ILE54-VAL74
Y	LEU91-GLY112
Y	LEU125-LEU150
Z	ALA9-GLY31
Z	ILE54-VAL74
Z	LEU91-GLY112
C	ALA1
Z	LEU125-LEU150
a	ALA9-GLY31
a	ILE54-VAL74
a	LEU91-GLY112
a	LEU125-LEU150
b	ALA9-GLY31
b	ILE54-VAL74
b	LEU91-GLY112
b	LEU125-LEU150
c	ALA9-GLY31
E	ALA1
c	ILE54-VAL74
c	LEU91-GLY112
c	LEU125-LEU150
V	LEU125-LEU150
W	ALA9-GLY31
W	ILE54-VAL74
W	LEU91-GLY112
W	LEU125-LEU150
X	ALA9-GLY31

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
A	THR130
Z	ASP113-ARG124
a	THR32-ASN53
a	ASP113-ARG124
b	THR32-ASN53
b	ASP113-ARG124
c	THR32-ASN53
c	ASP113-ARG124
C	THR130
E	THR130
W	ASP113-ARG124
X	THR32-ASN53
X	ASP113-ARG124
Y	THR32-ASN53
Y	ASP113-ARG124
Z	THR32-ASN53

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
e	ASN69
e	ASN104
e	ASN172
Y	GLU137
Z	GLU137
a	GLU137
b	GLU137
c	GLU137

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by ATM or ATR => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	SER511
D	SER511
F	SER511

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	SER515
D	SER515
F	SER515

site_id	SWS_FT_FI7
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
B	LYS14
B	LYS508
D	LYS14
D	LYS508
F	LYS14
F	LYS508

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	9
Details	M-CSA 508

Chain	Residue	Details
A	CYS283	covalent catalysis
A	SER358	electrostatic stabiliser
A	TRP360	electrostatic stabiliser
A	ALA361	proton shuttle (general acid/base)
A	SER583	proton shuttle (general acid/base)

site_id	MCSA2
Number of Residues	9
Details	M-CSA 508

Chain	Residue	Details
C	CYS283	covalent catalysis
C	SER358	electrostatic stabiliser
C	TRP360	electrostatic stabiliser
C	ALA361	proton shuttle (general acid/base)
C	SER583	proton shuttle (general acid/base)

site_id	MCSA3
Number of Residues	9
Details	M-CSA 508

Chain	Residue	Details
E	CYS283	covalent catalysis
E	SER358	electrostatic stabiliser
E	TRP360	electrostatic stabiliser
E	ALA361	proton shuttle (general acid/base)
E	SER583	proton shuttle (general acid/base)

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)