Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7FDA

CryoEM Structure of Reconstituted V-ATPase, state1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0046034	biological_process	ATP metabolic process
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0000329	cellular_component	fungal-type vacuole membrane
B	0000425	biological_process	pexophagy
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005774	cellular_component	vacuolar membrane
B	0006811	biological_process	monoatomic ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0007035	biological_process	vacuolar acidification
B	0010494	cellular_component	cytoplasmic stress granule
B	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
B	0033176	cellular_component	proton-transporting V-type ATPase complex
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0045121	cellular_component	membrane raft
B	0046034	biological_process	ATP metabolic process
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	0048388	biological_process	endosomal lumen acidification
B	0055085	biological_process	transmembrane transport
B	0061795	biological_process	Golgi lumen acidification
B	1902600	biological_process	proton transmembrane transport
B	1902906	biological_process	proteasome storage granule assembly
B	1990816	cellular_component	vacuole-mitochondrion membrane contact site
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0046034	biological_process	ATP metabolic process
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0000329	cellular_component	fungal-type vacuole membrane
D	0000425	biological_process	pexophagy
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005774	cellular_component	vacuolar membrane
D	0006811	biological_process	monoatomic ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0007035	biological_process	vacuolar acidification
D	0010494	cellular_component	cytoplasmic stress granule
D	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0045121	cellular_component	membrane raft
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0055085	biological_process	transmembrane transport
D	0061795	biological_process	Golgi lumen acidification
D	1902600	biological_process	proton transmembrane transport
D	1902906	biological_process	proteasome storage granule assembly
D	1990816	cellular_component	vacuole-mitochondrion membrane contact site
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0000329	cellular_component	fungal-type vacuole membrane
F	0000425	biological_process	pexophagy
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005774	cellular_component	vacuolar membrane
F	0006811	biological_process	monoatomic ion transport
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0007035	biological_process	vacuolar acidification
F	0010494	cellular_component	cytoplasmic stress granule
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0045121	cellular_component	membrane raft
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0055085	biological_process	transmembrane transport
F	0061795	biological_process	Golgi lumen acidification
F	1902600	biological_process	proton transmembrane transport
F	1902906	biological_process	proteasome storage granule assembly
F	1990816	cellular_component	vacuole-mitochondrion membrane contact site
G	0000139	cellular_component	Golgi membrane
G	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005515	molecular_function	protein binding
G	0005774	cellular_component	vacuolar membrane
G	0006811	biological_process	monoatomic ion transport
G	0007035	biological_process	vacuolar acidification
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
G	0045121	cellular_component	membrane raft
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0048388	biological_process	endosomal lumen acidification
G	0061795	biological_process	Golgi lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0000329	cellular_component	fungal-type vacuole membrane
H	0005515	molecular_function	protein binding
H	0005774	cellular_component	vacuolar membrane
H	0006811	biological_process	monoatomic ion transport
H	0007035	biological_process	vacuolar acidification
H	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
H	0016887	molecular_function	ATP hydrolysis activity
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0061795	biological_process	Golgi lumen acidification
H	1902600	biological_process	proton transmembrane transport
I	0000139	cellular_component	Golgi membrane
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0000329	cellular_component	fungal-type vacuole membrane
I	0005515	molecular_function	protein binding
I	0005774	cellular_component	vacuolar membrane
I	0006811	biological_process	monoatomic ion transport
I	0007035	biological_process	vacuolar acidification
I	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
I	0033176	cellular_component	proton-transporting V-type ATPase complex
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0045121	cellular_component	membrane raft
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0048388	biological_process	endosomal lumen acidification
I	0061795	biological_process	Golgi lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0000139	cellular_component	Golgi membrane
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0000329	cellular_component	fungal-type vacuole membrane
J	0005515	molecular_function	protein binding
J	0005774	cellular_component	vacuolar membrane
J	0006811	biological_process	monoatomic ion transport
J	0007035	biological_process	vacuolar acidification
J	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
J	0016887	molecular_function	ATP hydrolysis activity
J	0033176	cellular_component	proton-transporting V-type ATPase complex
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0048388	biological_process	endosomal lumen acidification
J	0061795	biological_process	Golgi lumen acidification
J	1902600	biological_process	proton transmembrane transport
K	0000139	cellular_component	Golgi membrane
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0000329	cellular_component	fungal-type vacuole membrane
K	0005515	molecular_function	protein binding
K	0005774	cellular_component	vacuolar membrane
K	0006811	biological_process	monoatomic ion transport
K	0007035	biological_process	vacuolar acidification
K	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
K	0033176	cellular_component	proton-transporting V-type ATPase complex
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0045121	cellular_component	membrane raft
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0048388	biological_process	endosomal lumen acidification
K	0061795	biological_process	Golgi lumen acidification
K	1902600	biological_process	proton transmembrane transport
L	0000139	cellular_component	Golgi membrane
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0000329	cellular_component	fungal-type vacuole membrane
L	0005515	molecular_function	protein binding
L	0005774	cellular_component	vacuolar membrane
L	0006811	biological_process	monoatomic ion transport
L	0007035	biological_process	vacuolar acidification
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0016887	molecular_function	ATP hydrolysis activity
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0048388	biological_process	endosomal lumen acidification
L	0061795	biological_process	Golgi lumen acidification
L	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005515	molecular_function	protein binding
M	0005774	cellular_component	vacuolar membrane
M	0006811	biological_process	monoatomic ion transport
M	0007035	biological_process	vacuolar acidification
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0045121	cellular_component	membrane raft
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0061795	biological_process	Golgi lumen acidification
M	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005515	molecular_function	protein binding
N	0005774	cellular_component	vacuolar membrane
N	0006811	biological_process	monoatomic ion transport
N	0007035	biological_process	vacuolar acidification
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0034220	biological_process	monoatomic ion transmembrane transport
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0061795	biological_process	Golgi lumen acidification
N	1902600	biological_process	proton transmembrane transport
O	0000139	cellular_component	Golgi membrane
O	0000166	molecular_function	nucleotide binding
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0000329	cellular_component	fungal-type vacuole membrane
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005774	cellular_component	vacuolar membrane
O	0006811	biological_process	monoatomic ion transport
O	0007035	biological_process	vacuolar acidification
O	0015078	molecular_function	proton transmembrane transporter activity
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0033176	cellular_component	proton-transporting V-type ATPase complex
O	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0048388	biological_process	endosomal lumen acidification
O	0061795	biological_process	Golgi lumen acidification
O	1902600	biological_process	proton transmembrane transport
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Q	0000324	cellular_component	fungal-type vacuole
Q	0000329	cellular_component	fungal-type vacuole membrane
Q	0005515	molecular_function	protein binding
Q	0005774	cellular_component	vacuolar membrane
Q	0006797	biological_process	polyphosphate metabolic process
Q	0006811	biological_process	monoatomic ion transport
Q	0007035	biological_process	vacuolar acidification
Q	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Q	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Q	0045121	cellular_component	membrane raft
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	0051117	molecular_function	ATPase binding
Q	0065003	biological_process	protein-containing complex assembly
Q	0071469	biological_process	cellular response to alkaline pH
Q	0071474	biological_process	cellular hyperosmotic response
Q	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
Q	1902600	biological_process	proton transmembrane transport
Q	1903778	biological_process	protein localization to vacuolar membrane
S	0000139	cellular_component	Golgi membrane
S	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
S	0000329	cellular_component	fungal-type vacuole membrane
S	0005515	molecular_function	protein binding
S	0005774	cellular_component	vacuolar membrane
S	0006811	biological_process	monoatomic ion transport
S	0007034	biological_process	vacuolar transport
S	0007035	biological_process	vacuolar acidification
S	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
S	0033176	cellular_component	proton-transporting V-type ATPase complex
S	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	0048388	biological_process	endosomal lumen acidification
S	0061795	biological_process	Golgi lumen acidification
S	1902600	biological_process	proton transmembrane transport
T	0000139	cellular_component	Golgi membrane
T	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
T	0000329	cellular_component	fungal-type vacuole membrane
T	0005774	cellular_component	vacuolar membrane
T	0006811	biological_process	monoatomic ion transport
T	0007035	biological_process	vacuolar acidification
T	0008553	molecular_function	P-type proton-exporting transporter activity
T	0015078	molecular_function	proton transmembrane transporter activity
T	0016020	cellular_component	membrane
T	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
T	0033176	cellular_component	proton-transporting V-type ATPase complex
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
T	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
T	0048388	biological_process	endosomal lumen acidification
T	0061795	biological_process	Golgi lumen acidification
T	1902600	biological_process	proton transmembrane transport
U	0000139	cellular_component	Golgi membrane
U	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
U	0000324	cellular_component	fungal-type vacuole
U	0000329	cellular_component	fungal-type vacuole membrane
U	0005774	cellular_component	vacuolar membrane
U	0006811	biological_process	monoatomic ion transport
U	0007035	biological_process	vacuolar acidification
U	0015078	molecular_function	proton transmembrane transporter activity
U	0016020	cellular_component	membrane
U	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
U	0033176	cellular_component	proton-transporting V-type ATPase complex
U	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
U	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
U	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
U	0048388	biological_process	endosomal lumen acidification
U	0061795	biological_process	Golgi lumen acidification
U	0071944	cellular_component	cell periphery
U	1902600	biological_process	proton transmembrane transport
V	0000139	cellular_component	Golgi membrane
V	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
V	0000329	cellular_component	fungal-type vacuole membrane
V	0005774	cellular_component	vacuolar membrane
V	0006623	biological_process	protein targeting to vacuole
V	0006811	biological_process	monoatomic ion transport
V	0006878	biological_process	intracellular copper ion homeostasis
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006897	biological_process	endocytosis
V	0007033	biological_process	vacuole organization
V	0007035	biological_process	vacuolar acidification
V	0015078	molecular_function	proton transmembrane transporter activity
V	0016020	cellular_component	membrane
V	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
V	0033176	cellular_component	proton-transporting V-type ATPase complex
V	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
V	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
V	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
V	0048388	biological_process	endosomal lumen acidification
V	0061795	biological_process	Golgi lumen acidification
V	1902600	biological_process	proton transmembrane transport
W	0000139	cellular_component	Golgi membrane
W	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
W	0000329	cellular_component	fungal-type vacuole membrane
W	0005774	cellular_component	vacuolar membrane
W	0006623	biological_process	protein targeting to vacuole
W	0006811	biological_process	monoatomic ion transport
W	0006878	biological_process	intracellular copper ion homeostasis
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006897	biological_process	endocytosis
W	0007033	biological_process	vacuole organization
W	0007035	biological_process	vacuolar acidification
W	0015078	molecular_function	proton transmembrane transporter activity
W	0016020	cellular_component	membrane
W	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
W	0033176	cellular_component	proton-transporting V-type ATPase complex
W	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
W	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
W	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
W	0048388	biological_process	endosomal lumen acidification
W	0061795	biological_process	Golgi lumen acidification
W	1902600	biological_process	proton transmembrane transport
X	0000139	cellular_component	Golgi membrane
X	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
X	0000329	cellular_component	fungal-type vacuole membrane
X	0005774	cellular_component	vacuolar membrane
X	0006623	biological_process	protein targeting to vacuole
X	0006811	biological_process	monoatomic ion transport
X	0006878	biological_process	intracellular copper ion homeostasis
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006897	biological_process	endocytosis
X	0007033	biological_process	vacuole organization
X	0007035	biological_process	vacuolar acidification
X	0015078	molecular_function	proton transmembrane transporter activity
X	0016020	cellular_component	membrane
X	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
X	0033176	cellular_component	proton-transporting V-type ATPase complex
X	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
X	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
X	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
X	0048388	biological_process	endosomal lumen acidification
X	0061795	biological_process	Golgi lumen acidification
X	1902600	biological_process	proton transmembrane transport
Y	0000139	cellular_component	Golgi membrane
Y	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Y	0000329	cellular_component	fungal-type vacuole membrane
Y	0005774	cellular_component	vacuolar membrane
Y	0006623	biological_process	protein targeting to vacuole
Y	0006811	biological_process	monoatomic ion transport
Y	0006878	biological_process	intracellular copper ion homeostasis
Y	0006879	biological_process	intracellular iron ion homeostasis
Y	0006897	biological_process	endocytosis
Y	0007033	biological_process	vacuole organization
Y	0007035	biological_process	vacuolar acidification
Y	0015078	molecular_function	proton transmembrane transporter activity
Y	0016020	cellular_component	membrane
Y	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Y	0033176	cellular_component	proton-transporting V-type ATPase complex
Y	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Y	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Y	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Y	0048388	biological_process	endosomal lumen acidification
Y	0061795	biological_process	Golgi lumen acidification
Y	1902600	biological_process	proton transmembrane transport
Z	0000139	cellular_component	Golgi membrane
Z	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Z	0000329	cellular_component	fungal-type vacuole membrane
Z	0005774	cellular_component	vacuolar membrane
Z	0006623	biological_process	protein targeting to vacuole
Z	0006811	biological_process	monoatomic ion transport
Z	0006878	biological_process	intracellular copper ion homeostasis
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006897	biological_process	endocytosis
Z	0007033	biological_process	vacuole organization
Z	0007035	biological_process	vacuolar acidification
Z	0015078	molecular_function	proton transmembrane transporter activity
Z	0016020	cellular_component	membrane
Z	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Z	0033176	cellular_component	proton-transporting V-type ATPase complex
Z	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Z	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Z	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Z	0048388	biological_process	endosomal lumen acidification
Z	0061795	biological_process	Golgi lumen acidification
Z	1902600	biological_process	proton transmembrane transport
a	0000139	cellular_component	Golgi membrane
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0000329	cellular_component	fungal-type vacuole membrane
a	0005774	cellular_component	vacuolar membrane
a	0006623	biological_process	protein targeting to vacuole
a	0006811	biological_process	monoatomic ion transport
a	0006878	biological_process	intracellular copper ion homeostasis
a	0006879	biological_process	intracellular iron ion homeostasis
a	0006897	biological_process	endocytosis
a	0007033	biological_process	vacuole organization
a	0007035	biological_process	vacuolar acidification
a	0015078	molecular_function	proton transmembrane transporter activity
a	0016020	cellular_component	membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0033176	cellular_component	proton-transporting V-type ATPase complex
a	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0048388	biological_process	endosomal lumen acidification
a	0061795	biological_process	Golgi lumen acidification
a	1902600	biological_process	proton transmembrane transport
b	0000139	cellular_component	Golgi membrane
b	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
b	0000329	cellular_component	fungal-type vacuole membrane
b	0005774	cellular_component	vacuolar membrane
b	0006623	biological_process	protein targeting to vacuole
b	0006811	biological_process	monoatomic ion transport
b	0006878	biological_process	intracellular copper ion homeostasis
b	0006879	biological_process	intracellular iron ion homeostasis
b	0006897	biological_process	endocytosis
b	0007033	biological_process	vacuole organization
b	0007035	biological_process	vacuolar acidification
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
b	0033176	cellular_component	proton-transporting V-type ATPase complex
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	0048388	biological_process	endosomal lumen acidification
b	0061795	biological_process	Golgi lumen acidification
b	1902600	biological_process	proton transmembrane transport
c	0000139	cellular_component	Golgi membrane
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0000329	cellular_component	fungal-type vacuole membrane
c	0005774	cellular_component	vacuolar membrane
c	0006623	biological_process	protein targeting to vacuole
c	0006811	biological_process	monoatomic ion transport
c	0006878	biological_process	intracellular copper ion homeostasis
c	0006879	biological_process	intracellular iron ion homeostasis
c	0006897	biological_process	endocytosis
c	0007033	biological_process	vacuole organization
c	0007035	biological_process	vacuolar acidification
c	0015078	molecular_function	proton transmembrane transporter activity
c	0016020	cellular_component	membrane
c	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
c	0033176	cellular_component	proton-transporting V-type ATPase complex
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0048388	biological_process	endosomal lumen acidification
c	0061795	biological_process	Golgi lumen acidification
c	1902600	biological_process	proton transmembrane transport
d	0000032	biological_process	cell wall mannoprotein biosynthetic process
d	0000139	cellular_component	Golgi membrane
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0000329	cellular_component	fungal-type vacuole membrane
d	0005774	cellular_component	vacuolar membrane
d	0006811	biological_process	monoatomic ion transport
d	0007035	biological_process	vacuolar acidification
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0048388	biological_process	endosomal lumen acidification
d	0055085	biological_process	transmembrane transport
d	0061795	biological_process	Golgi lumen acidification
d	0065003	biological_process	protein-containing complex assembly
d	1902600	biological_process	proton transmembrane transport
f	0000139	cellular_component	Golgi membrane
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0000329	cellular_component	fungal-type vacuole membrane
f	0003674	molecular_function	molecular_function
f	0004521	molecular_function	RNA endonuclease activity
f	0005575	cellular_component	cellular_component
f	0005774	cellular_component	vacuolar membrane
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0007035	biological_process	vacuolar acidification
f	0008150	biological_process	biological_process
f	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
f	0033176	cellular_component	proton-transporting V-type ATPase complex
f	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
f	0048388	biological_process	endosomal lumen acidification
f	0061795	biological_process	Golgi lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
B	PRO371-SER380
A	PRO452-SER461

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P38606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	36
Details	Region: {"description":"Interaction with VMA5","evidences":[{"source":"PubMed","id":"15751969","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	57
Details	Region: {"description":"Interaction with VMA10","evidences":[{"source":"PubMed","id":"15751969","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	118
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Peters C."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1135
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	321
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	318
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	65
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	34
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"9030535","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	8
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"1825730","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30910982","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	22
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30910982","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 508

Chain	Residue	Details
A	CYS283	covalent catalysis

site_id	MCSA2
Number of Residues	1
Details	M-CSA 508

Chain	Residue	Details
C	CYS283	covalent catalysis

site_id	MCSA3
Number of Residues	1
Details	M-CSA 508

Chain	Residue	Details
E	CYS283	covalent catalysis

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)