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7F8V

Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0001973biological_processG protein-coupled adenosine receptor signaling pathway
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007584biological_processresponse to nutrient
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0032930biological_processpositive regulation of superoxide anion generation
A0035810biological_processpositive regulation of urine volume
A0044297cellular_componentcell body
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0050804biological_processmodulation of chemical synaptic transmission
A0050805biological_processnegative regulation of synaptic transmission
A0051301biological_processcell division
A0051924biological_processregulation of calcium ion transport
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071878biological_processnegative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098992cellular_componentneuronal dense core vesicle
A1903561cellular_componentextracellular vesicle
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A2000179biological_processpositive regulation of neural precursor cell proliferation
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0001696biological_processgastric acid secretion
R0004930molecular_functionG protein-coupled receptor activity
R0004951molecular_functioncholecystokinin receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0008284biological_processpositive regulation of cell population proliferation
R0015054molecular_functiongastrin receptor activity
R0016020cellular_componentmembrane
R0017046molecular_functionpeptide hormone binding
R0031741molecular_functiontype B gastrin/cholecystokinin receptor binding
R0038188biological_processcholecystokinin signaling pathway
R0043231cellular_componentintracellular membrane-bounded organelle
R0045851biological_processpH reduction
R0046935molecular_function1-phosphatidylinositol-3-kinase regulator activity
R0048565biological_processdigestive tract development
R0048732biological_processgland development
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSTlSLVAIALERYSaI
ChainResidueDetails
RVAL140-ILE156

site_idPS00259
Number of Residues6
DetailsGASTRIN Gastrin / cholecystokinin family signature. Y.GWMDF
ChainResidueDetails
ETYR12-NFA17

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form gastrin => ECO:0000269|PubMed:5921183
ChainResidueDetails
EPCA1
AASP201
AASN270

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Sulfotyrosine; partial => ECO:0000269|PubMed:11052986, ECO:0000269|PubMed:7530658
ChainResidueDetails
ETYR12
RGLU151-HIS170
RARG243-ARG333
ASER327

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phenylalanine amide => ECO:0000269|PubMed:5921183
ChainResidueDetails
ENFA17

site_idSWS_FT_FI4
Number of Residues67
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RPHE110-SER131
RPRO190-SER219
RARG356-SER373

site_idSWS_FT_FI5
Number of Residues18
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RTYR132-LEU150

site_idSWS_FT_FI6
Number of Residues18
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RALA171-TYR189

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RVAL220-SER242

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RMET334-TRP355

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RPHE374-HIS394

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P17124
ChainResidueDetails
RCYS408

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN7
RASN30
RASN36

227111

PDB entries from 2024-11-06

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