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7F6H

Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin

Functional Information from GO Data
ChainGOidnamespacecontents
A0002020molecular_functionprotease binding
A0004435molecular_functionphosphatidylinositol phospholipase C activity
A0004930molecular_functionG protein-coupled receptor activity
A0004947molecular_functionbradykinin receptor activity
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006939biological_processsmooth muscle contraction
A0006954biological_processinflammatory response
A0007166biological_processcell surface receptor signaling pathway
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008015biological_processblood circulation
A0008643biological_processcarbohydrate transport
A0009651biological_processresponse to salt stress
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0016020cellular_componentmembrane
A0019229biological_processregulation of vasoconstriction
A0031702molecular_functiontype 1 angiotensin receptor binding
A0033137biological_processnegative regulation of peptidyl-serine phosphorylation
A0042311biological_processvasodilation
A0043114biological_processregulation of vascular permeability
A0043231cellular_componentintracellular membrane-bounded organelle
A0046982molecular_functionprotein heterodimerization activity
A0050482biological_processarachidonic acid secretion
A0055085biological_processtransmembrane transport
A1902219biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
A1902239biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
A1990127biological_processintrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
B0001508biological_processaction potential
B0001664molecular_functionG protein-coupled receptor binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005096molecular_functionGTPase activator activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005794cellular_componentGolgi apparatus
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0006469biological_processnegative regulation of protein kinase activity
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007202biological_processobsolete activation of phospholipase C activity
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007215biological_processglutamate receptor signaling pathway
B0007596biological_processblood coagulation
B0007603biological_processphototransduction, visible light
B0009649biological_processentrainment of circadian clock
B0010543biological_processregulation of platelet activation
B0016020cellular_componentmembrane
B0019001molecular_functionguanyl nucleotide binding
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0031965cellular_componentnuclear membrane
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0050821biological_processprotein stabilization
B0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
B0060828biological_processregulation of canonical Wnt signaling pathway
B0070062cellular_componentextracellular exosome
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIcFLMLVSIDRYLaL
ChainResidueDetails
ASER143-LEU159

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO-231-ASN-214

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by ACE => ECO:0000269|PubMed:4322742, ECO:0000269|PubMed:6055465
ChainResidueDetails
LPRO7

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by kallikrein => ECO:0000303|PubMed:3366244
ChainResidueDetails
LARG9
AASP154-LYS175
AGLN249-ARG267
AGLY336-GLN391
BALA331

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: 4-hydroxyproline; partial => ECO:0000269|PubMed:3182782, ECO:0000269|PubMed:3366244
ChainResidueDetails
LPRO3

site_idSWS_FT_FI4
Number of Residues52
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AASN119-ARG131
ALYS199-GLU221
AASP293-ASP311

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
AVAL132-ILE153

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
ALEU176-MET198

site_idSWS_FT_FI7
Number of Residues26
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AVAL222-MET248

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
AALA268-LEU292

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AVAL312-VAL335

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P25023
ChainResidueDetails
ATYR156
ATYR347

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P25023
ChainResidueDetails
ASER366

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P25023
ChainResidueDetails
ATHR369

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine; by GRK6 => ECO:0000269|PubMed:11517230
ChainResidueDetails
ASER373
ASER375

site_idSWS_FT_FI14
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
ACYS351

site_idSWS_FT_FI15
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN30
AASN39
AASN207

222926

PDB entries from 2024-07-24

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