7F4E

Crystal structure of Hst2 in complex with H3K9bz peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
C	LBZ9

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10911986, ECO:0000269|PubMed:10975519, ECO:0000269|PubMed:15719021

Chain	Residue	Details
C	SER10
A	GLN115
A	GLY223
A	ASN248
A	SER270

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-butyryllysine; alternate => ECO:0000269|PubMed:19113941, ECO:0000269|PubMed:27105113

Chain	Residue	Details
C	LYS14
A	CYS146
A	CYS170
A	CYS173

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 240

Chain	Residue	Details
A	PRO42	hydrogen bond acceptor, steric role
A	ASP43	hydrogen bond acceptor, hydrogen bond donor, steric role
A	PHE44	steric role, van der waals interaction
A	ARG45	electrostatic stabiliser, hydrogen bond donor
A	ASN116	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity
A	ASP118	activator, hydrogen bond acceptor
A	HIS135	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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