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7F1Q

Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0000165biological_processMAPK cascade
R0001618molecular_functionvirus receptor activity
R0001649biological_processosteoblast differentiation
R0001775biological_processcell activation
R0002407biological_processdendritic cell chemotaxis
R0002548biological_processmonocyte chemotaxis
R0003779molecular_functionactin binding
R0004435molecular_functionphosphatidylinositol phospholipase C activity
R0004672molecular_functionprotein kinase activity
R0004930molecular_functionG protein-coupled receptor activity
R0004950molecular_functionchemokine receptor activity
R0005125molecular_functioncytokine activity
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005615cellular_componentextracellular space
R0005737cellular_componentcytoplasm
R0005768cellular_componentendosome
R0005829cellular_componentcytosol
R0005886cellular_componentplasma membrane
R0006816biological_processcalcium ion transport
R0006874biological_processintracellular calcium ion homeostasis
R0006887biological_processexocytosis
R0006935biological_processchemotaxis
R0006952biological_processdefense response
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0006968biological_processcellular defense response
R0007010biological_processcytoskeleton organization
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007267biological_processcell-cell signaling
R0008009molecular_functionchemokine activity
R0008360biological_processregulation of cell shape
R0009636biological_processresponse to toxic substance
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0010628biological_processpositive regulation of gene expression
R0010629biological_processnegative regulation of gene expression
R0010818biological_processT cell chemotaxis
R0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
R0015026molecular_functioncoreceptor activity
R0016004molecular_functionphospholipase activator activity
R0016020cellular_componentmembrane
R0016301molecular_functionkinase activity
R0016493molecular_functionC-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019957molecular_functionC-C chemokine binding
R0023052biological_processsignaling
R0030335biological_processpositive regulation of cell migration
R0030502biological_processnegative regulation of bone mineralization
R0030593biological_processneutrophil chemotaxis
R0031726molecular_functionCCR1 chemokine receptor binding
R0031730molecular_functionCCR5 chemokine receptor binding
R0032731biological_processpositive regulation of interleukin-1 beta production
R0032760biological_processpositive regulation of tumor necrosis factor production
R0042056molecular_functionchemoattractant activity
R0042802molecular_functionidentical protein binding
R0043308biological_processeosinophil degranulation
R0043525biological_processpositive regulation of neuron apoptotic process
R0043615biological_processastrocyte cell migration
R0043922biological_processnegative regulation by host of viral transcription
R0045671biological_processnegative regulation of osteoclast differentiation
R0046718biological_processsymbiont entry into host cell
R0048020molecular_functionCCR chemokine receptor binding
R0048245biological_processeosinophil chemotaxis
R0048246biological_processmacrophage chemotaxis
R0048247biological_processlymphocyte chemotaxis
R0050729biological_processpositive regulation of inflammatory response
R0050795biological_processregulation of behavior
R0050850biological_processpositive regulation of calcium-mediated signaling
R0050918biological_processpositive chemotaxis
R0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0051928biological_processpositive regulation of calcium ion transport
R0051930biological_processregulation of sensory perception of pain
R0060326biological_processcell chemotaxis
R0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
R0070098biological_processchemokine-mediated signaling pathway
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0070723biological_processresponse to cholesterol
R0071222biological_processcellular response to lipopolysaccharide
R0071346biological_processcellular response to type II interferon
R0071347biological_processcellular response to interleukin-1
R0071356biological_processcellular response to tumor necrosis factor
R0071621biological_processgranulocyte chemotaxis
R0071791molecular_functionchemokine (C-C motif) ligand 5 binding
R0090280biological_processpositive regulation of calcium ion import
R1903980biological_processpositive regulation of microglial cell activation
R1904141biological_processpositive regulation of microglial cell migration
R2000110biological_processnegative regulation of macrophage apoptotic process
R2000503biological_processpositive regulation of natural killer cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIfFIILLTIDRYLaV
ChainResidueDetails
RSER210-VAL226

site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFsycsrq..IpqnfIadYfetssq..Cskp.GVIFltkrsrqv.CA
ChainResidueDetails
RCYS10-ALA51

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2
AASN269
RARG47

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
ATHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
RASP221-THR237
RLYS315-ARG331

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ALEU175

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
AASP200
RTHR263-ILE294
RGLN357-GLN373

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ASER326

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG178

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
AGLN204

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
ACYS351

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
ACYS3

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:21763489
ChainResidueDetails
RTYR106
RTYR110

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000255
ChainResidueDetails
RTYR111

site_idSWS_FT_FI14
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:11733580
ChainResidueDetails
RSER102
RSER103

222036

PDB entries from 2024-07-03

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