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7F0J

CryoEM structure of human Kv4.2

Functional Information from GO Data
ChainGOidnamespacecontents
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0030425cellular_componentdendrite
B0032809cellular_componentneuronal cell body membrane
B0034702cellular_componentmonoatomic ion channel complex
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045475biological_processlocomotor rhythm
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071193cellular_componentKv4.2-KChIP2 channel complex
B0071456biological_processcellular response to hypoxia
B0071805biological_processpotassium ion transmembrane transport
B0086009biological_processmembrane repolarization
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005250molecular_functionA-type (transient outward) potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019233biological_processsensory perception of pain
C0030425cellular_componentdendrite
C0032809cellular_componentneuronal cell body membrane
C0034702cellular_componentmonoatomic ion channel complex
C0042995cellular_componentcell projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0044853cellular_componentplasma membrane raft
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045475biological_processlocomotor rhythm
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0060078biological_processregulation of postsynaptic membrane potential
C0070161cellular_componentanchoring junction
C0071193cellular_componentKv4.2-KChIP2 channel complex
C0071456biological_processcellular response to hypoxia
C0071805biological_processpotassium ion transmembrane transport
C0086009biological_processmembrane repolarization
C0098978cellular_componentglutamatergic synapse
C0098982cellular_componentGABA-ergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
F0001508biological_processaction potential
F0005216molecular_functionmonoatomic ion channel activity
F0005249molecular_functionvoltage-gated potassium channel activity
F0005250molecular_functionA-type (transient outward) potassium channel activity
F0005267molecular_functionpotassium channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0006936biological_processmuscle contraction
F0007268biological_processchemical synaptic transmission
F0008016biological_processregulation of heart contraction
F0008076cellular_componentvoltage-gated potassium channel complex
F0016020cellular_componentmembrane
F0019228biological_processneuronal action potential
F0019233biological_processsensory perception of pain
F0030425cellular_componentdendrite
F0032809cellular_componentneuronal cell body membrane
F0034702cellular_componentmonoatomic ion channel complex
F0042995cellular_componentcell projection
F0043025cellular_componentneuronal cell body
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0044853cellular_componentplasma membrane raft
F0045202cellular_componentsynapse
F0045211cellular_componentpostsynaptic membrane
F0045475biological_processlocomotor rhythm
F0046872molecular_functionmetal ion binding
F0051260biological_processprotein homooligomerization
F0055085biological_processtransmembrane transport
F0060078biological_processregulation of postsynaptic membrane potential
F0070161cellular_componentanchoring junction
F0071193cellular_componentKv4.2-KChIP2 channel complex
F0071456biological_processcellular response to hypoxia
F0071805biological_processpotassium ion transmembrane transport
F0086009biological_processmembrane repolarization
F0098978cellular_componentglutamatergic synapse
F0098982cellular_componentGABA-ergic synapse
F0099634cellular_componentpostsynaptic specialization membrane
F1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
H0001508biological_processaction potential
H0005216molecular_functionmonoatomic ion channel activity
H0005249molecular_functionvoltage-gated potassium channel activity
H0005250molecular_functionA-type (transient outward) potassium channel activity
H0005267molecular_functionpotassium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0006936biological_processmuscle contraction
H0007268biological_processchemical synaptic transmission
H0008016biological_processregulation of heart contraction
H0008076cellular_componentvoltage-gated potassium channel complex
H0016020cellular_componentmembrane
H0019228biological_processneuronal action potential
H0019233biological_processsensory perception of pain
H0030425cellular_componentdendrite
H0032809cellular_componentneuronal cell body membrane
H0034702cellular_componentmonoatomic ion channel complex
H0042995cellular_componentcell projection
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0043204cellular_componentperikaryon
H0044853cellular_componentplasma membrane raft
H0045202cellular_componentsynapse
H0045211cellular_componentpostsynaptic membrane
H0045475biological_processlocomotor rhythm
H0046872molecular_functionmetal ion binding
H0051260biological_processprotein homooligomerization
H0055085biological_processtransmembrane transport
H0060078biological_processregulation of postsynaptic membrane potential
H0070161cellular_componentanchoring junction
H0071193cellular_componentKv4.2-KChIP2 channel complex
H0071456biological_processcellular response to hypoxia
H0071805biological_processpotassium ion transmembrane transport
H0086009biological_processmembrane repolarization
H0098978cellular_componentglutamatergic synapse
H0098982cellular_componentGABA-ergic synapse
H0099634cellular_componentpostsynaptic specialization membrane
H1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1684
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BMET1-THR182
FALA251-VAL261
FSER307-ALA321
FHIS414-LEU630
HMET1-THR182
HALA251-VAL261
HSER307-ALA321
HHIS414-LEU630
BALA251-VAL261
BSER307-ALA321
BHIS414-LEU630
CMET1-THR182
CALA251-VAL261
CSER307-ALA321
CHIS414-LEU630
FMET1-THR182

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BMET183-VAL204
CMET183-VAL204
FMET183-VAL204
HMET183-VAL204

site_idSWS_FT_FI3
Number of Residues192
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BGLU205-ALA228
FTHR280-SER286
FTYR344-ILE357
FPRO378-LYS384
HGLU205-ALA228
HTHR280-SER286
HTYR344-ILE357
HPRO378-LYS384
BTHR280-SER286
BTYR344-ILE357
BPRO378-LYS384
CGLU205-ALA228
CTHR280-SER286
CTYR344-ILE357
CPRO378-LYS384
FGLU205-ALA228

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BPHE229-ALA250
CPHE229-ALA250
FPHE229-ALA250
HPHE229-ALA250

site_idSWS_FT_FI5
Number of Residues68
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BMET262-MET279
CMET262-MET279
FMET262-MET279
HMET262-MET279

site_idSWS_FT_FI6
Number of Residues76
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BGLY287-HIS306
CGLY287-HIS306
FGLY287-HIS306
HGLY287-HIS306

site_idSWS_FT_FI7
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BSER322-PHE343
CSER322-PHE343
FSER322-PHE343
HSER322-PHE343

site_idSWS_FT_FI8
Number of Residues44
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BPRO358-THR369
CPRO358-THR369
FPRO358-THR369
HPRO358-THR369

site_idSWS_FT_FI9
Number of Residues28
DetailsINTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BTHR370-VAL377
CTHR370-VAL377
FTHR370-VAL377
HTHR370-VAL377

site_idSWS_FT_FI10
Number of Residues112
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
BILE385-TYR413
CILE385-TYR413
FILE385-TYR413
HILE385-TYR413

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
BHIS105
HHIS105
HCYS132
HCYS133
BCYS132
BCYS133
CHIS105
CCYS132
CCYS133
FHIS105
FCYS132
FCYS133

site_idSWS_FT_FI12
Number of Residues12
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
BTHR38
HTHR38
HTHR602
HTHR607
BTHR602
BTHR607
CTHR38
CTHR602
CTHR607
FTHR38
FTHR602
FTHR607

site_idSWS_FT_FI13
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
BSER438
BSER548
CSER438
CSER548
FSER438
FSER548
HSER438
HSER548

site_idSWS_FT_FI14
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0V2
ChainResidueDetails
BSER552
FSER572
FSER575
FSER616
HSER552
HSER572
HSER575
HSER616
BSER572
BSER575
BSER616
CSER552
CSER572
CSER575
CSER616
FSER552

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PDB entries from 2024-07-24

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