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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7F0J

CryoEM structure of human Kv4.2

Functional Information from GO Data
ChainGOidnamespacecontents
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0030425cellular_componentdendrite
B0032809cellular_componentneuronal cell body membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045475biological_processlocomotor rhythm
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071456biological_processcellular response to hypoxia
B0071805biological_processpotassium ion transmembrane transport
B0086009biological_processmembrane repolarization
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005250molecular_functionA-type (transient outward) potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006936biological_processmuscle contraction
C0007268biological_processchemical synaptic transmission
C0008016biological_processregulation of heart contraction
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019233biological_processsensory perception of pain
C0030425cellular_componentdendrite
C0032809cellular_componentneuronal cell body membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0044853cellular_componentplasma membrane raft
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045475biological_processlocomotor rhythm
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0060078biological_processregulation of postsynaptic membrane potential
C0070161cellular_componentanchoring junction
C0071456biological_processcellular response to hypoxia
C0071805biological_processpotassium ion transmembrane transport
C0086009biological_processmembrane repolarization
C0098978cellular_componentglutamatergic synapse
C0098982cellular_componentGABA-ergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
F0001508biological_processaction potential
F0005216molecular_functionmonoatomic ion channel activity
F0005249molecular_functionvoltage-gated potassium channel activity
F0005250molecular_functionA-type (transient outward) potassium channel activity
F0005267molecular_functionpotassium channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0006936biological_processmuscle contraction
F0007268biological_processchemical synaptic transmission
F0008016biological_processregulation of heart contraction
F0008076cellular_componentvoltage-gated potassium channel complex
F0016020cellular_componentmembrane
F0019228biological_processneuronal action potential
F0019233biological_processsensory perception of pain
F0030425cellular_componentdendrite
F0032809cellular_componentneuronal cell body membrane
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0043025cellular_componentneuronal cell body
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0044853cellular_componentplasma membrane raft
F0045202cellular_componentsynapse
F0045211cellular_componentpostsynaptic membrane
F0045475biological_processlocomotor rhythm
F0046872molecular_functionmetal ion binding
F0051260biological_processprotein homooligomerization
F0055085biological_processtransmembrane transport
F0060078biological_processregulation of postsynaptic membrane potential
F0070161cellular_componentanchoring junction
F0071456biological_processcellular response to hypoxia
F0071805biological_processpotassium ion transmembrane transport
F0086009biological_processmembrane repolarization
F0098978cellular_componentglutamatergic synapse
F0098982cellular_componentGABA-ergic synapse
F0099634cellular_componentpostsynaptic specialization membrane
F1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
H0001508biological_processaction potential
H0005216molecular_functionmonoatomic ion channel activity
H0005249molecular_functionvoltage-gated potassium channel activity
H0005250molecular_functionA-type (transient outward) potassium channel activity
H0005267molecular_functionpotassium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0006936biological_processmuscle contraction
H0007268biological_processchemical synaptic transmission
H0008016biological_processregulation of heart contraction
H0008076cellular_componentvoltage-gated potassium channel complex
H0016020cellular_componentmembrane
H0019228biological_processneuronal action potential
H0019233biological_processsensory perception of pain
H0030425cellular_componentdendrite
H0032809cellular_componentneuronal cell body membrane
H0034220biological_processmonoatomic ion transmembrane transport
H0034702cellular_componentmonoatomic ion channel complex
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0043204cellular_componentperikaryon
H0044853cellular_componentplasma membrane raft
H0045202cellular_componentsynapse
H0045211cellular_componentpostsynaptic membrane
H0045475biological_processlocomotor rhythm
H0046872molecular_functionmetal ion binding
H0051260biological_processprotein homooligomerization
H0055085biological_processtransmembrane transport
H0060078biological_processregulation of postsynaptic membrane potential
H0070161cellular_componentanchoring junction
H0071456biological_processcellular response to hypoxia
H0071805biological_processpotassium ion transmembrane transport
H0086009biological_processmembrane repolarization
H0098978cellular_componentglutamatergic synapse
H0098982cellular_componentGABA-ergic synapse
H0099634cellular_componentpostsynaptic specialization membrane
H1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues72
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues44
DetailsIntramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues28
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues76
DetailsRegion: {"description":"Interaction with KCNIP1","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues52
DetailsRegion: {"description":"S4-S5 linker","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues12
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35597238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35597238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UKC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35597238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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