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7EZK

Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
D0001764biological_processneuron migration
D0004930molecular_functionG protein-coupled receptor activity
D0004951molecular_functioncholecystokinin receptor activity
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007409biological_processaxonogenesis
D0016020cellular_componentmembrane
D0017046molecular_functionpeptide hormone binding
D0030900biological_processforebrain development
D0032870biological_processcellular response to hormone stimulus
D0038188biological_processcholecystokinin signaling pathway
D0042277molecular_functionpeptide binding
D0046883biological_processregulation of hormone secretion
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSTfNLVAISLERYGaI
ChainResidueDetails
DVAL127-ILE143

site_idPS00259
Number of Residues7
DetailsGASTRIN Gastrin / cholecystokinin family signature. YmGWMDF
ChainResidueDetails
PTYS2-PHE8

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:11076522
ChainResidueDetails
PTYS2
DLYS105-LYS115
DTYR179-HIS210
DTRP335-GLY349

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phenylalanine amide => ECO:0000269|PubMed:3856870
ChainResidueDetails
PPHE8

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
DGLU138-HIS157
DGLU235-ARG313
DASN374-GLN428
AASN259
ASER333

site_idSWS_FT_FI4
Number of Residues26
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
DILE78-LEU104

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
DTHR116-LEU137

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
DALA158-ILE178

site_idSWS_FT_FI7
Number of Residues23
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
DTHR211-LEU234

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
DMET314-ALA334

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
DTHR350-MET373

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
DCYS387

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN10
DASN24
DASN190

222624

PDB entries from 2024-07-17

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