7EY0
Local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-813 Fab and BD-744 Fab
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| N | 0016020 | cellular_component | membrane |
| N | 0019031 | cellular_component | viral envelope |
| N | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| N | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| N | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| N | 0055036 | cellular_component | virion membrane |
| N | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| R | 0016020 | cellular_component | membrane |
| R | 0019031 | cellular_component | viral envelope |
| R | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| R | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| R | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| R | 0055036 | cellular_component | virion membrane |
| R | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| B | TYR192-HIS198 | |
| H | TYR199-HIS205 | |
| L | TYR193-HIS199 | |
| A | TYR201-HIS207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| R | ALA688 | |
| N | ALA688 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| R | ILE818 | |
| N | ILE818 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | ASN20 | |
| R | SER1161 | |
| R | VAL1176 | |
| N | ASN17 | |
| N | SER1161 | |
| N | VAL1176 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | ASN64 | |
| N | THR1077 | |
| R | ASN125 | |
| R | ILE720 | |
| R | GLN804 | |
| R | THR1077 | |
| N | ASN61 | |
| N | ASN122 | |
| N | ILE720 | |
| N | GLN804 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | ASN77 | |
| R | ASN152 | |
| R | LEU1197 | |
| N | ASN74 | |
| N | ASN149 | |
| N | LEU1197 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | ASN168 | |
| N | ASN334 | |
| N | ARG346 | |
| N | GLU619 | |
| N | TYR660 | |
| N | HIS1101 | |
| R | ILE285 | |
| R | ASN334 | |
| R | ARG346 | |
| R | GLU619 | |
| R | TYR660 | |
| R | HIS1101 | |
| N | ASN165 | |
| N | ILE285 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | ASN237 | |
| R | ILE712 | |
| N | ASN234 | |
| N | ILE712 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| R | ILE326 | |
| N | ILE326 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| R | ARG328 | |
| N | ARG328 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | ASN606 | |
| N | ASN606 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| R | ASN679 | |
| R | PRO681 | |
| N | ASN679 | |
| N | PRO681 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| R | VAL1137 | |
| N | VAL1137 |
