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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7EWP

Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0006091biological_processgeneration of precursor metabolites and energy
A0007186biological_processG protein-coupled receptor signaling pathway
A0008218biological_processbioluminescence
A0016020cellular_componentmembrane
B0004930molecular_functionG protein-coupled receptor activity
B0006091biological_processgeneration of precursor metabolites and energy
B0007186biological_processG protein-coupled receptor signaling pathway
B0008218biological_processbioluminescence
B0016020cellular_componentmembrane
C0001965molecular_functionG-protein alpha-subunit binding
C0003924molecular_functionGTPase activity
C0005096molecular_functionGTPase activator activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0007186biological_processG protein-coupled receptor signaling pathway
C0008277biological_processregulation of G protein-coupled receptor signaling pathway
C0009968biological_processnegative regulation of signal transduction
C0016020cellular_componentmembrane
C0030425cellular_componentdendrite
C0031681molecular_functionG-protein beta-subunit binding
C0035556biological_processintracellular signal transduction
C0042734cellular_componentpresynaptic membrane
C0043005cellular_componentneuron projection
C0043547biological_processpositive regulation of GTPase activity
C0044292cellular_componentdendrite terminus
C0045211cellular_componentpostsynaptic membrane
C0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
C0051286cellular_componentcell tip
C0060078biological_processregulation of postsynaptic membrane potential
C0098793cellular_componentpresynapse
C0098978cellular_componentglutamatergic synapse
D0003924molecular_functionGTPase activity
D0005096molecular_functionGTPase activator activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007212biological_processG protein-coupled dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0030159molecular_functionsignaling receptor complex adaptor activity
D0030425cellular_componentdendrite
D0031682molecular_functionG-protein gamma-subunit binding
D0036367biological_processlight adaption
D0042734cellular_componentpresynaptic membrane
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051087molecular_functionprotein-folding chaperone binding
D0051286cellular_componentcell tip
D0098688cellular_componentparallel fiber to Purkinje cell synapse
D0098793cellular_componentpresynapse
D1902773cellular_componentGTPase activator complex
D1990603biological_processdark adaptation
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSSsqDgKVIVWDS
ChainResidueDetails
DILE78-SER92
DILE168-VAL182
DLEU298-VAL312
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues71
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues72
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36996198","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8C419","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues10
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues75
DetailsDomain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues115
DetailsDomain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10862767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues39
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues39
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues41
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues42
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues42
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues29
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

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PDB entries from 2025-10-08

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