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7EW1

Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 5 in complex with Gi protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0038036molecular_functionsphingosine-1-phosphate receptor activity
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
D0000287molecular_functionmagnesium ion binding
D0001664molecular_functionG protein-coupled receptor binding
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005834cellular_componentheterotrimeric G-protein complex
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
D0010854molecular_functionadenylate cyclase regulator activity
D0016787molecular_functionhydrolase activity
D0019001molecular_functionguanyl nucleotide binding
D0019003molecular_functionGDP binding
D0030496cellular_componentmidbody
D0031683molecular_functionG-protein beta/gamma-subunit complex binding
D0031749molecular_functionD2 dopamine receptor binding
D0031821molecular_functionG protein-coupled serotonin receptor binding
D0034695biological_processresponse to prostaglandin E
D0043434biological_processresponse to peptide hormone
D0043949biological_processregulation of cAMP-mediated signaling
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0046872molecular_functionmetal ion binding
D0051301biological_processcell division
D0060236biological_processregulation of mitotic spindle organization
D0070062cellular_componentextracellular exosome
D0072678biological_processT cell migration
D1904322biological_processcellular response to forskolin
D1904778biological_processpositive regulation of protein localization to cell cortex
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVlSLLAIALERSLtM
ChainResidueDetails
AALA121-MET137

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AMET1-ALA40
AASN92-ARG111
ATRP173-ALA192
AASP274-GLN287

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
AVAL41-LEU61
DTHR181

site_idSWS_FT_FI3
Number of Residues64
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AGLY62-PRO70
AARG133-THR151
AARG214-THR252

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
AMET71-ALA91

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
AGLU112-GLU132

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
ALEU152-GLY172

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
ATYR193-ALA213

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
ALEU253-LEU273

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
AALA288-LEU308

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS323

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN20

223790

PDB entries from 2024-08-14

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