Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7EVN

The cryo-EM structure of the DDX42-SF3b complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000124cellular_componentSAGA complex
A0000375biological_processRNA splicing, via transesterification reactions
A0000398biological_processmRNA splicing, via spliceosome
A0003676molecular_functionnucleic acid binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005684cellular_componentU2-type spliceosomal complex
A0005686cellular_componentU2 snRNP
A0005689cellular_componentU12-type spliceosomal complex
A0005730cellular_componentnucleolus
A0006282biological_processregulation of DNA repair
A0006397biological_processmRNA processing
A0008380biological_processRNA splicing
A0030620molecular_functionU2 snRNA binding
A0042177biological_processnegative regulation of protein catabolic process
A0043484biological_processregulation of RNA splicing
A0044877molecular_functionprotein-containing complex binding
A0045893biological_processpositive regulation of DNA-templated transcription
A0071005cellular_componentU2-type precatalytic spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A1903241biological_processU2-type prespliceosome assembly
B0000124cellular_componentSAGA complex
B0000398biological_processmRNA splicing, via spliceosome
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005684cellular_componentU2-type spliceosomal complex
B0005686cellular_componentU2 snRNP
B0005689cellular_componentU12-type spliceosomal complex
B0006282biological_processregulation of DNA repair
B0006397biological_processmRNA processing
B0008380biological_processRNA splicing
B0043484biological_processregulation of RNA splicing
B0045893biological_processpositive regulation of DNA-templated transcription
B0071005cellular_componentU2-type precatalytic spliceosome
B0071011cellular_componentprecatalytic spliceosome
B1903241biological_processU2-type prespliceosome assembly
B1990935molecular_functionsplicing factor binding
C0000245biological_processspliceosomal complex assembly
C0003729molecular_functionmRNA binding
D0000398biological_processmRNA splicing, via spliceosome
D0003677molecular_functionDNA binding
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005681cellular_componentspliceosomal complex
D0005684cellular_componentU2-type spliceosomal complex
D0005686cellular_componentU2 snRNP
D0005689cellular_componentU12-type spliceosomal complex
D0006397biological_processmRNA processing
D0008270molecular_functionzinc ion binding
D0008380biological_processRNA splicing
D0016363cellular_componentnuclear matrix
D0016607cellular_componentnuclear speck
D0045893biological_processpositive regulation of DNA-templated transcription
D0046872molecular_functionmetal ion binding
D0048863biological_processstem cell differentiation
D0071005cellular_componentU2-type precatalytic spliceosome
D0071011cellular_componentprecatalytic spliceosome
D1903241biological_processU2-type prespliceosome assembly
E0003676molecular_functionnucleic acid binding
E0003723molecular_functionRNA binding
E0003724molecular_functionRNA helicase activity
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0008104biological_processprotein localization
E0015030cellular_componentCajal body
E0016020cellular_componentmembrane
E0016607cellular_componentnuclear speck
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0042981biological_processregulation of apoptotic process
E0071004cellular_componentU2-type prespliceosome
E1903241biological_processU2-type prespliceosome assembly
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VFDEADRmF
ChainResidueDetails
EVAL405-PHE413

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH
ChainResidueDetails
APHE287-HIS293

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541
ChainResidueDetails
EALA297
DCYS72
DCYS75
DCYS85
AGLU306
AGLU352
AARG429
AASN916
DCYS46
DCYS49
DCYS58
DCYS61

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ELYS5
ALYS1171

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
EARG12
CCYS677
CGLU1205

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER58

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ESER96
CLYS562

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ESER104

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
ESER109
ESER111

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER185
ESER754

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ELYS899

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon