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7EU0

The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000418cellular_componentRNA polymerase IV complex
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006351biological_processDNA-templated transcription
A0010495biological_processsiRNA-mediated long-distance post-transcriptional gene silencing
A0016779molecular_functionnucleotidyltransferase activity
A0030422biological_processsiRNA processing
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0034062molecular_function5'-3' RNA polymerase activity
A0046872molecular_functionmetal ion binding
B0000418cellular_componentRNA polymerase IV complex
B0000419cellular_componentRNA polymerase V complex
B0000428cellular_componentDNA-directed RNA polymerase complex
B0000792cellular_componentheterochromatin
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0006306biological_processobsolete DNA methylation
B0006351biological_processDNA-templated transcription
B0016779molecular_functionnucleotidyltransferase activity
B0030422biological_processsiRNA processing
B0030880cellular_componentRNA polymerase complex
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0032549molecular_functionribonucleoside binding
B0034062molecular_function5'-3' RNA polymerase activity
B0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
B0046872molecular_functionmetal ion binding
B0050776biological_processregulation of immune response
B0050832biological_processdefense response to fungus
B0080188biological_processgene silencing by siRNA-directed DNA methylation
B0141007biological_processsiRNA-mediated retrotransposon silencing by heterochromatin formation
C0000418cellular_componentRNA polymerase IV complex
C0000419cellular_componentRNA polymerase V complex
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005665cellular_componentRNA polymerase II, core complex
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0006351biological_processDNA-templated transcription
C0010374biological_processstomatal complex development
C0010375biological_processstomatal complex patterning
C0046983molecular_functionprotein dimerization activity
E0000418cellular_componentRNA polymerase IV complex
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
E0005634cellular_componentnucleus
E0005665cellular_componentRNA polymerase II, core complex
E0006351biological_processDNA-templated transcription
E0016591cellular_componentRNA polymerase II, holoenzyme
F0000418cellular_componentRNA polymerase IV complex
F0000419cellular_componentRNA polymerase V complex
F0000428cellular_componentDNA-directed RNA polymerase complex
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005665cellular_componentRNA polymerase II, core complex
F0006351biological_processDNA-templated transcription
H0000418cellular_componentRNA polymerase IV complex
H0000419cellular_componentRNA polymerase V complex
H0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
H0005634cellular_componentnucleus
H0005665cellular_componentRNA polymerase II, core complex
H0006351biological_processDNA-templated transcription
I0000419cellular_componentRNA polymerase V complex
I0000428cellular_componentDNA-directed RNA polymerase complex
I0003676molecular_functionnucleic acid binding
I0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005665cellular_componentRNA polymerase II, core complex
I0005730cellular_componentnucleolus
I0006351biological_processDNA-templated transcription
I0008270molecular_functionzinc ion binding
I0016591cellular_componentRNA polymerase II, holoenzyme
I0046872molecular_functionmetal ion binding
J0000418cellular_componentRNA polymerase IV complex
J0000419cellular_componentRNA polymerase V complex
J0000428cellular_componentDNA-directed RNA polymerase complex
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
J0005634cellular_componentnucleus
J0005665cellular_componentRNA polymerase II, core complex
J0006351biological_processDNA-templated transcription
J0008270molecular_functionzinc ion binding
J0046872molecular_functionmetal ion binding
K0000418cellular_componentRNA polymerase IV complex
K0000419cellular_componentRNA polymerase V complex
K0000428cellular_componentDNA-directed RNA polymerase complex
K0001055molecular_functionRNA polymerase II activity
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
K0005634cellular_componentnucleus
K0005665cellular_componentRNA polymerase II, core complex
K0006351biological_processDNA-templated transcription
K0006366biological_processtranscription by RNA polymerase II
K0016591cellular_componentRNA polymerase II, holoenzyme
K0046983molecular_functionprotein dimerization activity
L0000418cellular_componentRNA polymerase IV complex
L0000428cellular_componentDNA-directed RNA polymerase complex
L0003677molecular_functionDNA binding
L0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
L0005634cellular_componentnucleus
L0005665cellular_componentRNA polymerase II, core complex
L0006351biological_processDNA-templated transcription
L0008270molecular_functionzinc ion binding
L0046872molecular_functionmetal ion binding
M0003723molecular_functionRNA binding
M0003727molecular_functionsingle-stranded RNA binding
M0003968molecular_functionRNA-dependent RNA polymerase activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005730cellular_componentnucleolus
M0009751biological_processresponse to salicylic acid
M0010495biological_processsiRNA-mediated long-distance post-transcriptional gene silencing
M0030422biological_processsiRNA processing
M0031047biological_processregulatory ncRNA-mediated gene silencing
M0034062molecular_function5'-3' RNA polymerase activity
M0046872molecular_functionmetal ion binding
M0050832biological_processdefense response to fungus
M0071667molecular_functionDNA/RNA hybrid binding
M0140745biological_processsiRNA transcription
Functional Information from PROSITE/UniProt
site_idPS00446
Number of Residues41
DetailsRNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NALRRvmisevptvAidlVeievNsSvlnDEfIAhRLGLIP
ChainResidueDetails
CASN35-PRO75

site_idPS01030
Number of Residues27
DetailsRNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCRECNNILypkedkeqkillyaCrnC
ChainResidueDetails
IPHE6-CYS32

site_idPS01110
Number of Residues14
DetailsRNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HVLVPEHqvLttEE
ChainResidueDetails
EHIS137-GLU150

site_idPS01111
Number of Residues15
DetailsRNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ
ChainResidueDetails
FTHR66-GLN80

site_idPS01112
Number of Residues10
DetailsRNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG
ChainResidueDetails
JILE2-GLY11

site_idPS01154
Number of Residues32
DetailsRNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. VerEdHTIgNiVrmqLhrdenVlfagYqlpHP
ChainResidueDetails
KVAL35-PRO66

site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKFSSmHGQKGV
ChainResidueDetails
BGLY911-VAL923

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04050
ChainResidueDetails
ACYS56
AASP451
ACYS59
ACYS67
AHIS70
ACYS97
ACYS100
ACYS121
AASP447
AASP449

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10145
ChainResidueDetails
ICYS7
ICYS10
ICYS29
ICYS32
BCYS1136

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472
ChainResidueDetails
ICYS76
ICYS79
ICYS103
ICYS108

221716

PDB entries from 2024-06-26

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