Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EU0

The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000418	cellular_component	RNA polymerase IV complex
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006351	biological_process	DNA-templated transcription
A	0010495	biological_process	siRNA-mediated long-distance post-transcriptional gene silencing
A	0016779	molecular_function	nucleotidyltransferase activity
A	0030422	biological_process	siRNA processing
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
B	0000418	cellular_component	RNA polymerase IV complex
B	0000419	cellular_component	RNA polymerase V complex
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000792	cellular_component	heterochromatin
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006306	biological_process	obsolete DNA methylation
B	0006351	biological_process	DNA-templated transcription
B	0016779	molecular_function	nucleotidyltransferase activity
B	0030422	biological_process	siRNA processing
B	0030880	cellular_component	RNA polymerase complex
B	0031047	biological_process	regulatory ncRNA-mediated gene silencing
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0035194	biological_process	regulatory ncRNA-mediated post-transcriptional gene silencing
B	0046872	molecular_function	metal ion binding
B	0050776	biological_process	regulation of immune response
B	0050832	biological_process	defense response to fungus
B	0080188	biological_process	gene silencing by siRNA-directed DNA methylation
B	0141007	biological_process	siRNA-mediated retrotransposon silencing by heterochromatin formation
C	0000418	cellular_component	RNA polymerase IV complex
C	0000419	cellular_component	RNA polymerase V complex
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006351	biological_process	DNA-templated transcription
C	0010374	biological_process	stomatal complex development
C	0010375	biological_process	stomatal complex patterning
C	0046983	molecular_function	protein dimerization activity
E	0000418	cellular_component	RNA polymerase IV complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0006351	biological_process	DNA-templated transcription
F	0000418	cellular_component	RNA polymerase IV complex
F	0000419	cellular_component	RNA polymerase V complex
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005665	cellular_component	RNA polymerase II, core complex
F	0006351	biological_process	DNA-templated transcription
H	0000418	cellular_component	RNA polymerase IV complex
H	0000419	cellular_component	RNA polymerase V complex
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005665	cellular_component	RNA polymerase II, core complex
H	0006351	biological_process	DNA-templated transcription
I	0000419	cellular_component	RNA polymerase V complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006351	biological_process	DNA-templated transcription
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000418	cellular_component	RNA polymerase IV complex
J	0000419	cellular_component	RNA polymerase V complex
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0006351	biological_process	DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0046872	molecular_function	metal ion binding
K	0000418	cellular_component	RNA polymerase IV complex
K	0000419	cellular_component	RNA polymerase V complex
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0046983	molecular_function	protein dimerization activity
L	0000418	cellular_component	RNA polymerase IV complex
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005665	cellular_component	RNA polymerase II, core complex
L	0006351	biological_process	DNA-templated transcription
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0003723	molecular_function	RNA binding
M	0003727	molecular_function	single-stranded RNA binding
M	0003968	molecular_function	RNA-dependent RNA polymerase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0009751	biological_process	response to salicylic acid
M	0010495	biological_process	siRNA-mediated long-distance post-transcriptional gene silencing
M	0030422	biological_process	siRNA processing
M	0031047	biological_process	regulatory ncRNA-mediated gene silencing
M	0034062	molecular_function	5'-3' RNA polymerase activity
M	0046872	molecular_function	metal ion binding
M	0050832	biological_process	defense response to fungus
M	0071667	molecular_function	DNA/RNA hybrid binding
M	0140745	biological_process	siRNA transcription

Functional Information from PROSITE/UniProt

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NALRRvmisevptvAidlVeievNsSvlnDEfIAhRLGLIP

Chain	Residue	Details
C	ASN35-PRO75

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCRECNNILypkedkeqkillyaCrnC

Chain	Residue	Details
I	PHE6-CYS32

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HVLVPEHqvLttEE

Chain	Residue	Details
E	HIS137-GLU150

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
F	THR66-GLN80

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. VerEdHTIgNiVrmqLhrdenVlfagYqlpHP

Chain	Residue	Details
K	VAL35-PRO66

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFSSmHGQKGV

Chain	Residue	Details
B	GLY911-VAL923

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P04050

Chain	Residue	Details
A	CYS56
A	ASP451
A	CYS59
A	CYS67
A	HIS70
A	CYS97
A	CYS100
A	CYS121
A	ASP447
A	ASP449

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU10145

Chain	Residue	Details
I	CYS7
I	CYS10
I	CYS29
I	CYS32
B	CYS1136

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00472

Chain	Residue	Details
I	CYS76
I	CYS79
I	CYS103
I	CYS108

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)