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7EPC

Cryo-EM structure of inactive mGlu7 homodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001642molecular_functiongroup III metabotropic glutamate receptor activity
A0001662biological_processbehavioral fear response
A0004930molecular_functionG protein-coupled receptor activity
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007186biological_processG protein-coupled receptor signaling pathway
A0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A0007216biological_processG protein-coupled glutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007605biological_processsensory perception of sound
A0008066molecular_functionglutamate receptor activity
A0010855molecular_functionadenylate cyclase inhibitor activity
A0014050biological_processnegative regulation of glutamate secretion
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032279cellular_componentasymmetric synapse
A0043198cellular_componentdendritic shaft
A0043235cellular_componentreceptor complex
A0045211cellular_componentpostsynaptic membrane
A0046983molecular_functionprotein dimerization activity
A0048786cellular_componentpresynaptic active zone
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0061564biological_processaxon development
A0070085biological_processglycosylation
A0070905molecular_functionserine binding
B0001642molecular_functiongroup III metabotropic glutamate receptor activity
B0001662biological_processbehavioral fear response
B0004930molecular_functionG protein-coupled receptor activity
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0007186biological_processG protein-coupled receptor signaling pathway
B0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
B0007216biological_processG protein-coupled glutamate receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0007605biological_processsensory perception of sound
B0008066molecular_functionglutamate receptor activity
B0010855molecular_functionadenylate cyclase inhibitor activity
B0014050biological_processnegative regulation of glutamate secretion
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032279cellular_componentasymmetric synapse
B0043198cellular_componentdendritic shaft
B0043235cellular_componentreceptor complex
B0045211cellular_componentpostsynaptic membrane
B0046983molecular_functionprotein dimerization activity
B0048786cellular_componentpresynaptic active zone
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0061564biological_processaxon development
B0070085biological_processglycosylation
B0070905molecular_functionserine binding
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNILrLFqIPQISyASTA
ChainResidueDetails
AVAL165-ALA183

site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWtCepCdgyqYqf...DemTCqhC
ChainResidueDetails
ACYS541-CYS563

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKyIGFTM
ChainResidueDetails
APHE784-MET794

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1206
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN35-TRP590
ALYS649-VAL654
AASP724-ASP753
ATHR811-LEU825
BGLN35-TRP590
BLYS649-VAL654
BASP724-ASP753
BTHR811-LEU825

site_idSWS_FT_FI2
Number of Residues48
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AALA591-TYR615
BALA591-TYR615

site_idSWS_FT_FI3
Number of Residues98
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AASN616-GLU627
ALYS676-GLN702
ALYS776-LYS788
BASN616-GLU627
BLYS676-GLN702
BLYS776-LYS788

site_idSWS_FT_FI4
Number of Residues40
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ALEU628-ALA648
BLEU628-ALA648

site_idSWS_FT_FI5
Number of Residues40
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
ACYS655-THR675
BCYS655-THR675

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
ALEU703-VAL723
BLEU703-VAL723

site_idSWS_FT_FI7
Number of Residues42
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
ALEU754-PHE775
BLEU754-PHE775

site_idSWS_FT_FI8
Number of Residues42
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
ATYR789-GLY810
BTYR789-GLY810

site_idSWS_FT_FI9
Number of Residues48
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
ATHR826-PHE850
BTHR826-PHE850

site_idSWS_FT_FI10
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER159
BLYS407
AALA180
ATYR230
AASP314
ALYS407
BSER159
BALA180
BTYR230
BASP314

site_idSWS_FT_FI11
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN98
AASN458
AASN486
AASN572
BASN98
BASN458
BASN486
BASN572

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PDB entries from 2024-07-31

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