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7EPA

Cryo-EM structure of inactive mGlu2 homodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001641molecular_functiongroup II metabotropic glutamate receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0005246molecular_functioncalcium channel regulator activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007216biological_processG protein-coupled glutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0008066molecular_functionglutamate receptor activity
A0010467biological_processgene expression
A0014047biological_processglutamate secretion
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0035095biological_processbehavioral response to nicotine
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060292biological_processlong-term synaptic depression
A0090461biological_processintracellular glutamate homeostasis
A0097110molecular_functionscaffold protein binding
A0097449cellular_componentastrocyte projection
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A2001023biological_processregulation of response to drug
B0001641molecular_functiongroup II metabotropic glutamate receptor activity
B0004930molecular_functionG protein-coupled receptor activity
B0005246molecular_functioncalcium channel regulator activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0007194biological_processnegative regulation of adenylate cyclase activity
B0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
B0007215biological_processglutamate receptor signaling pathway
B0007216biological_processG protein-coupled glutamate receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0008066molecular_functionglutamate receptor activity
B0010467biological_processgene expression
B0014047biological_processglutamate secretion
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0035095biological_processbehavioral response to nicotine
B0042220biological_processresponse to cocaine
B0042734cellular_componentpresynaptic membrane
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0045202cellular_componentsynapse
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0060292biological_processlong-term synaptic depression
B0090461biological_processintracellular glutamate homeostasis
B0097110molecular_functionscaffold protein binding
B0097449cellular_componentastrocyte projection
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B2001023biological_processregulation of response to drug
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS
ChainResidueDetails
AVAL151-SER169

site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWlCipCqpyeYrl...DefTCadC
ChainResidueDetails
ACYS518-CYS540

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM
ChainResidueDetails
APHE756-MET766

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1182
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLU19-TRP567
ALYS626-ARG636
AGLU701-ASP725
ASER784-THR793
BGLU19-TRP567
BLYS626-ARG636
BGLU701-ASP725
BSER784-THR793

site_idSWS_FT_FI2
Number of Residues44
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AALA568-VAL590
BALA568-VAL590

site_idSWS_FT_FI3
Number of Residues96
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AARG591-GLU604
AARG656-GLN679
ALYS748-LYS760
BARG591-GLU604
BARG656-GLN679
BLYS748-LYS760

site_idSWS_FT_FI4
Number of Residues40
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ALEU605-ALA625
BLEU605-ALA625

site_idSWS_FT_FI5
Number of Residues36
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
ALEU637-TYR655
BLEU637-TYR655

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AVAL680-VAL700
BVAL680-VAL700

site_idSWS_FT_FI7
Number of Residues42
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AALA726-PHE747
BALA726-PHE747

site_idSWS_FT_FI8
Number of Residues44
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
APHE761-THR783
BPHE761-THR783

site_idSWS_FT_FI9
Number of Residues50
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AMET794-PHE819
BMET794-PHE819

site_idSWS_FT_FI10
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BASP295
BLYS377
ALYS377
BSER145
BALA166
BTYR216
ASER145
AALA166
ATYR216
AASP295

site_idSWS_FT_FI11
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN203
BASN286
BASN338
BASN402
BASN547
AASN203
AASN286
AASN338
AASN402
AASN547

219869

PDB entries from 2024-05-15

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