7EOV
Crystal structure of mouse cytosolic sulfotransferase mSULT2A8 in complex with PAP and cholic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004027 | molecular_function | alcohol sulfotransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008206 | biological_process | bile acid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030573 | biological_process | bile acid catabolic process |
| A | 0033876 | molecular_function | glycochenodeoxycholate sulfotransferase activity |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0047704 | molecular_function | bile-salt sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| A | 0051923 | biological_process | sulfation |
| A | 0160025 | biological_process | sensory perception of itch |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue A3P A 301 |
| Chain | Residue |
| A | LYS44 |
| A | ILE218 |
| A | PHE220 |
| A | MET223 |
| A | ILE242 |
| A | MET243 |
| A | ARG244 |
| A | LYS245 |
| A | GLY246 |
| A | SER45 |
| A | GLY46 |
| A | THR47 |
| A | HIS48 |
| A | TRP49 |
| A | ARG121 |
| A | SER129 |
| A | TYR184 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue CHD A 302 |
| Chain | Residue |
| A | TYR17 |
| A | TYR18 |
| A | HIS48 |
| A | ALA71 |
| A | TRP77 |
| A | PHE80 |
| A | PHE134 |
| A | TYR159 |
| A | ILE236 |
| A | GLU237 |
| A | LYS238 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CHD A 303 |
| Chain | Residue |
| A | THR59 |
| A | ASP62 |
| A | TRP65 |
| A | LYS90 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"29685090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33872606","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33872606","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
